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CAMK1D calcium/calmodulin dependent protein kinase ID [ Homo sapiens (human) ]

Gene ID: 57118, updated on 5-Mar-2024

Summary

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Official Symbol
CAMK1Dprovided by HGNC
Official Full Name
calcium/calmodulin dependent protein kinase IDprovided by HGNC
Primary source
HGNC:HGNC:19341
See related
Ensembl:ENSG00000183049 MIM:607957; AllianceGenome:HGNC:19341
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CKLiK; CaM-K1; CaMKID
Summary
This gene is a member of the calcium/calmodulin-dependent protein kinase 1 family, a subfamily of the serine/threonine kinases. The encoded protein is a component of the calcium-regulated calmodulin-dependent protein kinase cascade. It has been associated with multiple processes including regulation of granulocyte function, activation of CREB-dependent gene transcription, aldosterone synthesis, differentiation and activation of neutrophil cells, and apoptosis of erythroleukemia cells. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jan 2015]
Expression
Broad expression in brain (RPKM 10.9), skin (RPKM 4.6) and 21 other tissues See more
Orthologs
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Genomic context

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See CAMK1D in Genome Data Viewer
Location:
10p13
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (12349547..12835545)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (12360834..12849903)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (12391546..12877545)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3037 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:12267705-12268640 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:12268641-12269574 Neighboring gene FOXA motif-containing MPRA enhancer 241 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2139 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:12306176-12306714 Neighboring gene cell division cycle 123 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:12365022-12365522 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:12365523-12366023 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3039 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2141 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2142 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2143 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:12391861-12392360 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3040 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2144 Neighboring gene RNA, 7SL, cytoplasmic 198, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:12430241-12430740 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:12430790-12431290 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2145 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3041 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3042 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:12490405-12491604 Neighboring gene RNA, U6atac small nuclear 39, pseudogene Neighboring gene uncharacterized LOC107984209 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:12524423-12525029 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3043 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3044 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:12531623-12532583 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3045 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2146 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2147 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:12594952-12595452 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:12595691-12595888 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3046 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3047 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:12680729-12681229 Neighboring gene microRNA 4480 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3048 Neighboring gene Sharpr-MPRA regulatory region 13393 Neighboring gene microRNA 4481 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2148 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:12781907-12782408 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:12782409-12782908 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:12808306-12808806 Neighboring gene microRNA 548q Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:12830027-12830528 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:12830529-12831028 Neighboring gene NANOG hESC enhancer GRCh37_chr10:12838401-12838902 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:12845476-12845976 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:12845977-12846477 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:12849244-12849744 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:12860895-12861500 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:12861501-12862105 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:12862106-12862710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:12891157-12891656 Neighboring gene uncharacterized LOC105376418 Neighboring gene 10p13 CCDC3 distal Alu-mediated recombination region Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:12958041-12958581 Neighboring gene RNA, 5S ribosomal pseudogene 300 Neighboring gene coiled-coil domain containing 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:13042842-13043342 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:13043343-13043843 Neighboring gene 10p13 CCDC3 medial Alu-mediated recombination region Neighboring gene NANOG hESC enhancer GRCh37_chr10:13091983-13092484 Neighboring gene ribosomal protein L5 pseudogene 25

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genome-wide association study identifies CAMKID variants involved in blood pressure response to losartan: the SOPHIA study. Frau F, et al. Pharmacogenomics, 2014 Sep. PMID 25410890
  2. Analysis of protein-protein interaction network in chronic obstructive pulmonary disease. Yuan YP, et al. Genet Mol Res, 2014 Oct 31. PMID 25366777
  3. Investigation into the promoter DNA methylation of three genes (CAMK1D, CRY2 and CALM2) in the peripheral blood of patients with type 2 diabetes. Cheng J, et al. Exp Ther Med, 2014 Aug. PMID 25009623, Free PMC Article
  4. CAMK1D amplification implicated in epithelial-mesenchymal transition in basal-like breast cancer. Bergamaschi A, et al. Mol Oncol, 2008 Dec. PMID 19383354, Free PMC Article
  5. CAMK1D Triggers Immune Resistance of Human Tumor Cells Refractory to Anti-PD-L1 Treatment. Volpin V, et al. Cancer Immunol Res, 2020 Sep. PMID 32665263

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CircPRKCI regulates proliferation, migration and cycle of lung adenocarcinoma cells by targeting miR-219a-5p-regulated CAMK1D.
    Title: CircPRKCI regulates proliferation, migration and cycle of lung adenocarcinoma cells by targeting miR-219a-5p-regulated CAMK1D.
  2. Associations of SUCNR1, GRK4, CAMK1D gene polymorphisms and the susceptibility of type 2 diabetes mellitus and essential hypertension in a northern Chinese Han population.
    Title: Associations of SUCNR1, GRK4, CAMK1D gene polymorphisms and the susceptibility of type 2 diabetes mellitus and essential hypertension in a northern Chinese Han population.
  3. CAMK1D Triggers Immune Resistance of Human Tumor Cells Refractory to Anti-PD-L1 Treatment.
    Title: CAMK1D Triggers Immune Resistance of Human Tumor Cells Refractory to Anti-PD-L1 Treatment.
  4. Cross-talk between eIF5A and CAMK1D enhances proliferation.
    Title: Eukaryotic initiation factor 5A and Ca(2+) /calmodulin-dependent protein kinase 1D modulate trophoblast cell function.
  5. There were no statistically significant differences in the distribution of CDC123/CAMK1D rs12779790 genotypes and alleles between women with gestational diabetes mellitus and healthy pregnant women.
    Title: CDC123/CAMK1D gene rs12779790 polymorphism and rs10811661 polymorphism upstream of the CDKN2A/2B gene in women with gestational diabetes.
  6. identified the CAMK1D gene as a novel locus associated with blood pressure response to losartan
    Title: Genome-wide association study identifies CAMKID variants involved in blood pressure response to losartan: the SOPHIA study.
  7. Substantiation of the roles of CAMK1D and CDKAL1 in gluconeogenic and glyconeogenic pathways in primary human hepatocytes.
    Title: RNAi screening in primary human hepatocytes of genes implicated in genome-wide association studies for roles in type 2 diabetes identifies roles for CAMK1D and CDKAL1, among others, in hepatic glucose regulation.
  8. Association to type 2 diabetes was found for rs13266634 (SLC30A8), rs7923837 (HHEX), rs10811661 (CDKN2A/2B), rs4402960 (IGF2BP2), rs12779790 (CDC123/CAMK1D), and rs2237892 (KCNQ1).
    Title: Contribution of common genetic variation to the risk of type 2 diabetes in the Mexican Mestizo population.
  9. A significant association of rs10906115 in CDC123/CAMK1D and rs1359790 near SPRY2 was identified with type 2 diabetes in a Japanese population.
    Title: Genetic variants at CDC123/CAMK1D and SPRY2 are associated with susceptibility to type 2 diabetes in the Japanese population.
  10. Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
    Title: Variations in/nearby genes coding for JAZF1, TSPAN8/LGR5 and HHEX-IDE and risk of type 2 diabetes in Han Chinese.
Submit: New GeneRIF Correction See all GeneRIFs (21)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
EBI GWAS Catalog
Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval.
EBI GWAS Catalog
Genetic variants associated with disordered eating.
EBI GWAS Catalog
Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
EBI GWAS Catalog
Identification of new genetic risk variants for type 2 diabetes.
EBI GWAS Catalog
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of calcium/calmodulin-dependent protein kinase ID (CAMK1D) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ40058

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of CREB transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of neutrophil chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of phagocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of respiratory burst IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of dendrite development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of granulocyte chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in intracellular anatomical structure IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
calcium/calmodulin-dependent protein kinase type 1D
Names
CAMK1D/ANAPC5 fusion
CaM kinase ID
CamKI-like protein kinase
caM kinase I delta
caM-KI delta
caMKI delta
NP_001337961.1
NP_065130.1
NP_705718.1
XP_006717545.1
XP_006717546.1
XP_011517893.1
XP_011517894.1
XP_011517895.1
XP_011517897.1
XP_047281493.1
XP_054222341.1
XP_054222342.1
XP_054222343.1
XP_054222344.1
XP_054222345.1
XP_054222346.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001351032.2 → NP_001337961.1  calcium/calmodulin-dependent protein kinase type 1D isoform 3

    Status: REVIEWED

    Source sequence(s)
    AA903749, AF286366, AK289393, AL391314, AL512783, BQ059621, HY156642
    Conserved Domains (1) summary
    cl21453
    Location:1 → 215
    PKc_like; Protein Kinases, catalytic domain

  2. NM_020397.4 → NP_065130.1  calcium/calmodulin-dependent protein kinase type 1D isoform 1

    See identical proteins and their annotated locations for NP_065130.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks the 3' terminal exon used in variant 2, and its 3' terminal exon extends past a splice site that is used in variant 2. It encodes isoform 1, which has a shorter and distinct C-terminus, compared to isoform 2.
    Source sequence(s)
    AA903749, AF286366, AK289393, AL512783, BQ059621, HY168807
    Consensus CDS
    CCDS7092.1
    UniProtKB/TrEMBL
    Q5SQQ7
    Related
    ENSP00000368122.1, ENST00000378845.5
    Conserved Domains (1) summary
    cd14168
    Location:12 → 312
    STKc_CaMKI_delta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I delta

  3. NM_153498.4 → NP_705718.1  calcium/calmodulin-dependent protein kinase type 1D isoform 2

    See identical proteins and their annotated locations for NP_705718.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).
    Source sequence(s)
    AB081726, AK289393, AL512783, BC035745, BC073155, HY168807, KF510334
    Consensus CDS
    CCDS7091.1
    UniProtKB/Swiss-Prot
    B0YIY0, Q8IU85, Q9HD31
    Related
    ENSP00000478874.1, ENST00000619168.5
    Conserved Domains (1) summary
    cd14168
    Location:12 → 312
    STKc_CaMKI_delta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I delta

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    12349547..12835545
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006717483.5 → XP_006717546.1  calcium/calmodulin-dependent protein kinase type 1D isoform X3

    See identical proteins and their annotated locations for XP_006717546.1

    Conserved Domains (1) summary
    cd14168
    Location:12 → 312
    STKc_CaMKI_delta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I delta

  2. XM_006717482.4 → XP_006717545.1  calcium/calmodulin-dependent protein kinase type 1D isoform X2

    Conserved Domains (1) summary
    cd14168
    Location:12 → 312
    STKc_CaMKI_delta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I delta

  3. XM_047425537.1 → XP_047281493.1  calcium/calmodulin-dependent protein kinase type 1D isoform X6

  4. XM_011519591.4 → XP_011517893.1  calcium/calmodulin-dependent protein kinase type 1D isoform X1

    Conserved Domains (1) summary
    cd14083
    Location:18 → 265
    STKc_CaMKI; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I

  5. XM_011519595.4 → XP_011517897.1  calcium/calmodulin-dependent protein kinase type 1D isoform X6

    See identical proteins and their annotated locations for XP_011517897.1

    Conserved Domains (1) summary
    cl21453
    Location:1 → 215
    PKc_like; Protein Kinases, catalytic domain

  6. XM_011519593.4 → XP_011517895.1  calcium/calmodulin-dependent protein kinase type 1D isoform X5

    Conserved Domains (2) summary
    smart00220
    Location:1 → 205
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:2 → 238
    PKc_like; Protein Kinases, catalytic domain

  7. XM_011519592.4 → XP_011517894.1  calcium/calmodulin-dependent protein kinase type 1D isoform X4

    Conserved Domains (2) summary
    smart00220
    Location:6 → 209
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:6 → 242
    PKc_like; Protein Kinases, catalytic domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    12360834..12849903
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054366368.1 → XP_054222343.1  calcium/calmodulin-dependent protein kinase type 1D isoform X3

  2. XM_054366367.1 → XP_054222342.1  calcium/calmodulin-dependent protein kinase type 1D isoform X2

  3. XM_054366366.1 → XP_054222341.1  calcium/calmodulin-dependent protein kinase type 1D isoform X1

  4. XM_054366371.1 → XP_054222346.1  calcium/calmodulin-dependent protein kinase type 1D isoform X6

  5. XM_054366370.1 → XP_054222345.1  calcium/calmodulin-dependent protein kinase type 1D isoform X5

  6. XM_054366369.1 → XP_054222344.1  calcium/calmodulin-dependent protein kinase type 1D isoform X4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_027322.1: Suppressed sequence

    Description
    NR_027322.1: This RefSeq was permanently suppressed because it is primarily UTR sequence.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IU85.1 GenPept UniProtKB/Swiss-Prot:Q8IU85

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