arg1 arginase 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: arg1provided by ZNC
Official Full Name: arginase 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040724-181
See related: Ensembl:ENSDARG00000057429 AllianceGenome:ZFIN:ZDB-GENE-040724-181
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zC146F4.3; SI:zC146F4.4; si:ch211-146f4.3
Summary: Predicted to enable arginase activity and manganese ion binding activity. Predicted to be involved in arginine catabolic process to ornithine. Predicted to act upstream of or within arginine metabolic process. Predicted to be active in cytosol. Is expressed in digestive system; eye; and reproductive system. Human ortholog(s) of this gene implicated in asthma; hepatocellular carcinoma; and hyperargininemia. Orthologous to human ARG1 (arginase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (9597151..9617770, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (9559308..9579927, complement)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables arginase activity	IBA Inferred from Biological aspect of Ancestor more info
enables arginase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	IEA Inferred from Electronic Annotation more info
enables manganese ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in arginine catabolic process to ornithine	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within arginine metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within urea cycle	IEA Inferred from Electronic Annotation more info
involved_in urea cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: arginase-1

Names: arginase, liver

NP_001038662.1

EC 3.5.3.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001045197.1 → NP_001038662.1 arginase-1

Status: PROVISIONAL

Source sequence(s)

AL732629

UniProtKB/TrEMBL

A0A8M1NA41, E7F8R4

Related

ENSDARP00000097045.3, ENSDART00000106267.5

Conserved Domains (1) summary

cd09989
Location:28 → 321

Arginase; Arginase family