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Adam18 ADAM metallopeptidase domain 18 [ Rattus norvegicus (Norway rat) ]

Gene ID: 57029, updated on 2-May-2024

Summary

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Official Symbol
Adam18provided by RGD
Official Full Name
ADAM metallopeptidase domain 18provided by RGD
Primary source
RGD:620405
See related
Ensembl:ENSRNOG00000017683 AllianceGenome:RGD:620405
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
tMDCIII
Summary
Predicted to enable metalloendopeptidase activity. Predicted to be involved in binding activity of sperm to zona pellucida and cell adhesion. Predicted to be integral component of membrane. Orthologous to human ADAM18 (ADAM metallopeptidase domain 18). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 36.9) See more
Orthologs
human mouse all
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Genomic context

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Location:
16q12.4-q12.5
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (74054974..74127861)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (67352360..67425820)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (72139100..72210902)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase domain 5 Neighboring gene ADAM metallopeptidase domain 3A Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC108348416 Neighboring gene indoleamine 2,3-dioxygenase 1 Neighboring gene indoleamine 2,3-dioxygenase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Human tMDC III: a sperm protein with a potential role in oocyte recognition. Frayne J, et al. Mol Hum Reprod, 2002 Sep. PMID 12200459
  2. Rat MDC family of proteins: sequence analysis, tissue distribution, and expression in prepubertal and adult rat testis. Frayne J, et al. Mol Reprod Dev, 1997 Oct. PMID 9291465
  3. Macaque MDC family of proteins: sequence analysis, tissue distribution and processing in the male reproductive tract. Frayne J, et al. Mol Hum Reprod, 1998 May. PMID 9665629
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
disintegrin and metalloproteinase domain-containing protein 18
Names
ADAM 18
a disintegrin and metallopeptidase domain 18
a disintegrin and metalloproteinase domain 18
tMDC III
transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein III

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001375316.1 → NP_001362245.1  disintegrin and metalloproteinase domain-containing protein 18 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A6IW32
    Conserved Domains (4) summary
    smart00608
    Location:473 → 611
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:181 → 374
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:394 → 469
    Disintegrin
    pfam01562
    Location:25 → 140
    Pep_M12B_propep; Reprolysin family propeptide

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    74054974..74127861
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039094795.2 → XP_038950723.1  disintegrin and metalloproteinase domain-containing protein 18 isoform X1

    UniProtKB/TrEMBL
    A6IW32, F1LRY9
    Conserved Domains (4) summary
    smart00608
    Location:507 → 645
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:215 → 408
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:428 → 503
    Disintegrin
    pfam01562
    Location:59 → 174
    Pep_M12B_propep; Reprolysin family propeptide

  2. XM_039094796.2 → XP_038950724.1  disintegrin and metalloproteinase domain-containing protein 18 isoform X3

    UniProtKB/TrEMBL
    A6IW32
    Conserved Domains (4) summary
    smart00608
    Location:507 → 645
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:215 → 408
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:428 → 503
    Disintegrin
    pfam01562
    Location:59 → 174
    Pep_M12B_propep; Reprolysin family propeptide

  3. XM_039094794.2 → XP_038950722.1  disintegrin and metalloproteinase domain-containing protein 18 isoform X1

    UniProtKB/TrEMBL
    A6IW32, F1LRY9
    Related
    ENSRNOP00000023805.6
    Conserved Domains (4) summary
    smart00608
    Location:507 → 645
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:215 → 408
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:428 → 503
    Disintegrin
    pfam01562
    Location:59 → 174
    Pep_M12B_propep; Reprolysin family propeptide

  4. XM_063275669.1 → XP_063131739.1  disintegrin and metalloproteinase domain-containing protein 18 isoform X2

  5. XM_063275670.1 → XP_063131740.1  disintegrin and metalloproteinase domain-containing protein 18 isoform X4

  6. XM_063275671.1 → XP_063131741.1  disintegrin and metalloproteinase domain-containing protein 18 isoform X5

RNA

  1. XR_005494666.2 RNA Sequence

  2. XR_010058314.1 RNA Sequence

  3. XR_010058313.1 RNA Sequence

  4. XR_010058312.1 RNA Sequence

  5. XR_010058316.1 RNA Sequence

  6. XR_010058315.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97776.1 GenPept UniProtKB/Swiss-Prot:P97776

Gene LinkOut

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