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fignl1 fidgetin-like 1 [ Danio rerio (zebrafish) ]

Gene ID: 569539, updated on 11-Apr-2024

Summary

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Official Symbol
fignl1provided by ZNC
Official Full Name
fidgetin-like 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-1862
See related
Ensembl:ENSDARG00000016427 AllianceGenome:ZFIN:ZDB-GENE-030131-1862
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fb82h05; wu:fb82h05; wu:fj99a11; zgc:193664
Summary
Enables protein-macromolecule adaptor activity. Acts upstream of or within microtubule cytoskeleton organization. Is expressed in head; nervous system; neural tube; tail bud; and vertical myoseptum. Orthologous to human FIGNL1 (fidgetin like 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 13
Exon count:
2
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (15933111..15943938)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (15802143..15812942)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene kinesin light chain 1a Neighboring gene si:ch211-57f7.7 Neighboring gene uncharacterized LOC101883107 Neighboring gene tubulin tyrosine ligase Neighboring gene IKAROS family zinc finger 1 (Ikaros) Neighboring gene chromosome 13 C7orf72 homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Motor axon navigation relies on Fidgetin-like 1-driven microtubule plus end dynamics. Fassier C, et al. J Cell Biol, 2018 May 7. PMID 29535193, Free PMC Article
  2. Fidgetin-like 1 is a ciliogenesis-inhibitory centrosome protein. Zhao X, et al. Cell Cycle, 2016 Sep. PMID 27384458, Free PMC Article
  3. FIGNL1 associates with KIF1Bβ and BICD1 to restrict dynein transport velocity during axon navigation. Atkins M, et al. J Cell Biol, 2019 Oct 7. PMID 31541015, Free PMC Article
  4. Brorin is required for neurogenesis, gliogenesis, and commissural axon guidance in the zebrafish forebrain. Miyake A, et al. PLoS One, 2017. PMID 28448525, Free PMC Article
  5. A comparative study of the expression patterns of Fign family members in zebrafish embryonic development. Dong Z, et al. Comp Biochem Physiol B Biochem Mol Biol, 2021 Jan. PMID 33069857

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study thus pinpoints Fignl1 as a multifaceted key player in MT remodeling underlying motor circuit connectivity.
    Title: Motor axon navigation relies on Fidgetin-like 1-driven microtubule plus end dynamics.
  2. FIGL-1 is a new centrosomal protein and inhibits ciliogenesis.
    Title: Fidgetin-like 1 is a ciliogenesis-inhibitory centrosome protein.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables microtubule severing ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-macromolecule adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-macromolecule adaptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within microtubule cytoskeleton organization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
fidgetin-like protein 1
NP_001122223.1
XP_005156740.1
XP_005156741.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128751.1 → NP_001122223.1  fidgetin-like protein 1

    See identical proteins and their annotated locations for NP_001122223.1

    Status: PROVISIONAL

    Source sequence(s)
    BC162519
    UniProtKB/TrEMBL
    A0A8M2B2R1, B3DGU1
    Related
    ENSDARP00000017944.6, ENSDART00000016294.8
    Conserved Domains (3) summary
    smart00382
    Location:420 → 556
    AAA; ATPases associated with a variety of cellular activities
    pfam00004
    Location:424 → 554
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam09336
    Location:610 → 658
    Vps4_C; Vps4 C terminal oligomerization domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    15933111..15943938
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005156683.4 → XP_005156740.1  fidgetin-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005156740.1

    UniProtKB/TrEMBL
    A0A8M2B2R1, B3DGU1
    Related
    ENSDARP00000117905.1, ENSDART00000131390.2
    Conserved Domains (3) summary
    smart00382
    Location:420 → 556
    AAA; ATPases associated with a variety of cellular activities
    pfam00004
    Location:424 → 554
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam09336
    Location:610 → 658
    Vps4_C; Vps4 C terminal oligomerization domain

  2. XM_005156684.4 → XP_005156741.1  fidgetin-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005156741.1

    UniProtKB/TrEMBL
    A0A8M2B2R1, B3DGU1
    Conserved Domains (3) summary
    smart00382
    Location:420 → 556
    AAA; ATPases associated with a variety of cellular activities
    pfam00004
    Location:424 → 554
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam09336
    Location:610 → 658
    Vps4_C; Vps4 C terminal oligomerization domain
Nucleotide Protein
Heading Accession and Version

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