pecam1a platelet and endothelial cell adhesion molecule 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pecam1aprovided by ZNC
Official Full Name: platelet and endothelial cell adhesion molecule 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-130530-689
See related: Ensembl:ENSDARG00000060263 AllianceGenome:ZFIN:ZDB-GENE-130530-689
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: CD31; pecam1; zmp:0000000686
Summary: Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in cell surface receptor signaling pathway and cell-cell adhesion via plasma-membrane adhesion molecules. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Human ortholog(s) of this gene implicated in coronary artery disease (multiple); lung non-small cell carcinoma; neuroblastoma; and psoriatic arthritis. Orthologous to human PECAM1 (platelet and endothelial cell adhesion molecule 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (59784617..59819471)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (59491902..59525950)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WASp controls oriented migration of endothelial cells to achieve functional vascular patterning.
Title: WASp controls oriented migration of endothelial cells to achieve functional vascular patterning.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion via plasma-membrane adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: platelet endothelial cell adhesion molecule

Names: platelet/endothelial cell adhesion molecule 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113799.1 → NP_001107271.1 platelet endothelial cell adhesion molecule precursor

Status: PROVISIONAL

Source sequence(s)

BC125877

UniProtKB/TrEMBL

A0A8M1NHB4, A0JMH1

Conserved Domains (3) summary

smart00409
Location:492 → 560

IG; Immunoglobulin

pfam13895
Location:305 → 383

Ig_2; Immunoglobulin domain

pfam13927
Location:29 → 103

Ig_3; Immunoglobulin domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007114.7 Reference GRCz11 Primary Assembly

Range

59784617..59819471

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005164273.4 → XP_005164330.1 platelet endothelial cell adhesion molecule isoform X1

UniProtKB/TrEMBL

A0A8M2BBR3, A0JMH1, F1R1B9

Related

ENSDARP00000079164.4, ENSDART00000084729.5

Conserved Domains (3) summary

smart00410
Location:225 → 299

IG_like; Immunoglobulin like

pfam13895
Location:306 → 383

Ig_2; Immunoglobulin domain

pfam13927
Location:30 → 103

Ig_3; Immunoglobulin domain
XM_021471101.1 → XP_021326776.1 platelet endothelial cell adhesion molecule isoform X2

UniProtKB/TrEMBL

A0A8M9PWY1, A0JMH1

Conserved Domains (3) summary

smart00409
Location:225 → 299

IG; Immunoglobulin

pfam13895
Location:305 → 383

Ig_2; Immunoglobulin domain

pfam13927
Location:480 → 560

Ig_3; Immunoglobulin domain