U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

btk Bruton agammaglobulinemia tyrosine kinase [ Danio rerio (zebrafish) ]

Gene ID: 568653, updated on 27-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
btkprovided by ZNC
Official Full Name
Bruton agammaglobulinemia tyrosine kinaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070531-1
See related
Ensembl:ENSDARG00000004433 AllianceGenome:ZFIN:ZDB-GENE-070531-1
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable protein tyrosine kinase activity. Acts upstream of or within anterior/posterior pattern specification; negative regulation of Wnt signaling pathway; and regulation of canonical Wnt signaling pathway. Is expressed in hematopoietic system. Human ortholog(s) of this gene implicated in agammaglobulinemia (multiple); isolated growth hormone deficiency type III; and lymphoma (multiple). Orthologous to human BTK (Bruton tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 14
Exon count:
18
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (38892033..38930006, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (38551406..38589641, complement)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene zgc:101583 Neighboring gene translocase of inner mitochondrial membrane 8 homolog A (yeast) Neighboring gene galactosidase, alpha Neighboring gene glycine receptor, alpha 4a

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A network-based approach to identify deregulated pathways and drug effects in metabolic syndrome. Misselbeck K, et al. Nat Commun, 2019 Nov 18. PMID 31740673, Free PMC Article
  2. Bruton's tyrosine kinase revealed as a negative regulator of Wnt-beta-catenin signaling. James RG, et al. Sci Signal, 2009 May 26. PMID 19471023, Free PMC Article
  3. The Bruton's Tyrosine Kinase Inhibitor Ibrutinib Impairs the Vascular Development of Zebrafish Larvae. Wang K, et al. Front Pharmacol, 2020. PMID 33519491, Free PMC Article
  4. Bacterial Quorum-Sensing Signal DSF Inhibits LPS-Induced Inflammations by Suppressing Toll-like Receptor Signaling and Preventing Lysosome-Mediated Apoptosis in Zebrafish. Zhu H, et al. Int J Mol Sci, 2022 Jun 26. PMID 35806111, Free PMC Article
  5. Individual knock out of glycine receptor alpha subunits identifies a specific requirement of glra1 for motor function in zebrafish. Samarut E, et al. PLoS One, 2019. PMID 31048868, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in B cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adaptive immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within anterior/posterior pattern specification IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
tyrosine-protein kinase BTK
XP_021336920.1
XP_697087.5

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    38892033..38930006 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021481245.1 → XP_021336920.1  tyrosine-protein kinase BTK

    UniProtKB/TrEMBL
    A0A8M9QPK4, F8W3B7
    Related
    ENSDARP00000124430.1, ENSDART00000148737.3
    Conserved Domains (4) summary
    cd01238
    Location:6 → 145
    PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
    cl15255
    Location:252 → 357
    SH2; Src homology 2 (SH2) domain
    cl17036
    Location:195 → 249
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:376 → 630
    PKc_like; Protein Kinases, catalytic domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394925.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    160923..197171 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_691995.8 → XP_697087.5  tyrosine-protein kinase BTK

    UniProtKB/TrEMBL
    A0A8N7UW23
    Conserved Domains (4) summary
    cd01238
    Location:6 → 145
    PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
    cl15255
    Location:252 → 357
    SH2; Src homology 2 (SH2) domain
    cl17036
    Location:195 → 249
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:376 → 630
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous