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pleca plectin a [ Danio rerio (zebrafish) ]

Gene ID: 567639, updated on 27-Mar-2024

Summary

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Official Symbol
plecaprovided by ZNC
Official Full Name
plectin aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-8984
See related
Ensembl:ENSDARG00000062590 AllianceGenome:ZFIN:ZDB-GENE-030131-8984
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fa95h11; sb:eu420; plec1-like; wu:fa95h11; si:dkey-151c10.1
Summary
Predicted to enable ankyrin binding activity and structural molecule activity. Predicted to be a structural constituent of cytoskeleton and structural constituent of muscle. Acts upstream of or within locomotory behavior and skeletal muscle tissue development. Predicted to be located in cytoskeleton. Predicted to be integral component of membrane. Predicted to be active in several cellular components, including focal adhesion; hemidesmosome; and sarcolemma. Predicted to colocalize with intermediate filament. Is expressed in epidermis and yolk syncytial layer. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2Q; epidermolysis bullosa simplex; epidermolysis bullosa simplex Ogna type; and epidermolysis bullosa simplex with muscular dystrophy. Orthologous to human PLEC (plectin). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 19
Exon count:
45
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (22408308..22621646, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (22823985..22894565, complement)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 52 member 2 Neighboring gene F-box and leucine-rich repeat protein 6 Neighboring gene epiplakin 1 Neighboring gene eukaryotic translation initiation factor 3, subunit E, b Neighboring gene transmembrane protein 74-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. MiR-202-3p determines embryo viability during mid-blastula transition. Hu R, et al. Front Cell Dev Biol, 2022. PMID 36003151, Free PMC Article
  2. Microglial transglutaminase-2 drives myelination and myelin repair via GPR56/ADGRG1 in oligodendrocyte precursor cells. Giera S, et al. Elife, 2018 May 29. PMID 29809138, Free PMC Article
  3. Elucidating mechanisms of immunotoxicity by benzotriazole ultraviolet stabilizers in zebrafish (Danio rerio): Implication of the AHR-IL17/IL22 immune pathway. Li Z, et al. Environ Pollut, 2020 Jul. PMID 32146360
  4. In vivo characterization of human myofibrillar myopathy genes in zebrafish. Bührdel JB, et al. Biochem Biophys Res Commun, 2015 May 29. PMID 25866181
  5. Zebrafish: a model system to study heritable skin diseases. Li Q, et al. J Invest Dermatol, 2011 Mar. PMID 21191402, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables ankyrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of muscle IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in hemidesmosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intermediate filament cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within intermediate filament cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within skeletal muscle tissue development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in wound healing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in hemidesmosome IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with intermediate filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in sarcolemma IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
plectin a; plectin
Names
plec

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100032.1 → NP_001093502.1  plectin a

    Status: PROVISIONAL

    Source sequence(s)
    CR855260
    UniProtKB/TrEMBL
    A0A8M1NF92, A5WV02
    Related
    ENSDARP00000085112.5, ENSDART00000090679.7
    Conserved Domains (13) summary
    smart00150
    Location:534 → 628
    SPEC; Spectrin repeats
    smart00250
    Location:2773 → 2810
    PLEC; Plectin repeat
    COG1196
    Location:965 → 1664
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00014
    Location:44 → 146
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:629 → 819
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00307
    Location:161 → 258
    CH; Calponin homology (CH) domain
    pfam00681
    Location:4042 → 4083
    Plectin; Plectin repeat
    pfam01576
    Location:1351 → 2450
    Myosin_tail_1; Myosin tail
    cd16269
    Location:2586 → 2597
    GBP_C; coiled coil [structural motif]
    cl02488
    Location:1132 → 1302
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl12013
    Location:2206 → 2440
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl17036
    Location:821 → 866
    SH3; Src Homology 3 domain superfamily
    cl20817
    Location:2525 → 2614
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    22408308..22621646 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021468105.1 → XP_021323780.1  plectin isoform X6

    UniProtKB/TrEMBL
    A0A8M9PRP2, E7F8G7
    Related
    ENSDARP00000085102.5, ENSDART00000090669.7
    Conserved Domains (9) summary
    smart00150
    Location:719 → 813
    SPEC; Spectrin repeats
    smart00250
    Location:2958 → 2995
    PLEC; Plectin repeat
    COG5069
    Location:223 → 445
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00176
    Location:814 → 1004
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:4227 → 4266
    Plectin; Plectin repeat
    cl17036
    Location:1006 → 1051
    SH3; Src Homology 3 domain superfamily
    cl25732
    Location:1150 → 1849
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26511
    Location:1963 → 2808
    Neuromodulin_N; Gap junction protein N-terminal region
    cl27652
    Location:3212 → 3250
    Plectin; Plectin repeat

  2. XM_021468103.1 → XP_021323778.1  plectin isoform X4

    UniProtKB/TrEMBL
    A0A286YBE9, A0A8M9PB19
    Related
    ENSDARP00000144502.1, ENSDART00000175106.2
    Conserved Domains (9) summary
    smart00150
    Location:719 → 813
    SPEC; Spectrin repeats
    smart00250
    Location:2969 → 3006
    PLEC; Plectin repeat
    COG5069
    Location:223 → 445
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00176
    Location:814 → 1004
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:4238 → 4277
    Plectin; Plectin repeat
    cl17036
    Location:1006 → 1051
    SH3; Src Homology 3 domain superfamily
    cl25732
    Location:1234 → 1780
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26511
    Location:1974 → 2819
    Neuromodulin_N; Gap junction protein N-terminal region
    cl27652
    Location:3223 → 3261
    Plectin; Plectin repeat

  3. XM_021468104.1 → XP_021323779.1  plectin isoform X5

    UniProtKB/TrEMBL
    A0A8M9PGI1
    Conserved Domains (9) summary
    smart00150
    Location:724 → 818
    SPEC; Spectrin repeats
    smart00250
    Location:2963 → 3000
    PLEC; Plectin repeat
    COG5069
    Location:223 → 450
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00176
    Location:819 → 1009
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:4232 → 4271
    Plectin; Plectin repeat
    cl17036
    Location:1011 → 1056
    SH3; Src Homology 3 domain superfamily
    cl25732
    Location:1155 → 1854
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26511
    Location:1968 → 2813
    Neuromodulin_N; Gap junction protein N-terminal region
    cl27652
    Location:3217 → 3255
    Plectin; Plectin repeat

  4. XM_021468102.1 → XP_021323777.1  plectin isoform X3

    UniProtKB/TrEMBL
    A0A8M9P1W1
    Conserved Domains (9) summary
    smart00150
    Location:724 → 818
    SPEC; Spectrin repeats
    smart00250
    Location:2974 → 3011
    PLEC; Plectin repeat
    COG5069
    Location:223 → 450
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00176
    Location:819 → 1009
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:4243 → 4282
    Plectin; Plectin repeat
    cl17036
    Location:1011 → 1056
    SH3; Src Homology 3 domain superfamily
    cl25732
    Location:1239 → 1785
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26511
    Location:1979 → 2824
    Neuromodulin_N; Gap junction protein N-terminal region
    cl27652
    Location:3228 → 3266
    Plectin; Plectin repeat

  5. XM_021468101.1 → XP_021323776.1  plectin isoform X2

    UniProtKB/TrEMBL
    A0A8M9PNE8
    Conserved Domains (9) summary
    smart00150
    Location:736 → 830
    SPEC; Spectrin repeats
    smart00250
    Location:2975 → 3012
    PLEC; Plectin repeat
    COG5069
    Location:223 → 462
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00176
    Location:831 → 1021
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:4244 → 4283
    Plectin; Plectin repeat
    cl17036
    Location:1023 → 1068
    SH3; Src Homology 3 domain superfamily
    cl25732
    Location:1167 → 1866
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26511
    Location:1980 → 2825
    Neuromodulin_N; Gap junction protein N-terminal region
    cl27652
    Location:3229 → 3267
    Plectin; Plectin repeat

  6. XM_021468100.1 → XP_021323775.1  plectin isoform X1

    UniProtKB/TrEMBL
    A0A8M9PRN8
    Conserved Domains (9) summary
    smart00150
    Location:736 → 830
    SPEC; Spectrin repeats
    smart00250
    Location:2986 → 3023
    PLEC; Plectin repeat
    COG5069
    Location:223 → 462
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00176
    Location:831 → 1021
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:4255 → 4294
    Plectin; Plectin repeat
    cl17036
    Location:1023 → 1068
    SH3; Src Homology 3 domain superfamily
    cl25732
    Location:1251 → 1797
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26511
    Location:1991 → 2836
    Neuromodulin_N; Gap junction protein N-terminal region
    cl27652
    Location:3240 → 3278
    Plectin; Plectin repeat

  7. XM_021468106.1 → XP_021323781.1  plectin isoform X7

    UniProtKB/TrEMBL
    A0A8M9PNF5
    Conserved Domains (9) summary
    smart00150
    Location:576 → 670
    SPEC; Spectrin repeats
    smart00250
    Location:2826 → 2863
    PLEC; Plectin repeat
    COG5069
    Location:63 → 302
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00176
    Location:671 → 861
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:4095 → 4134
    Plectin; Plectin repeat
    cl17036
    Location:863 → 908
    SH3; Src Homology 3 domain superfamily
    cl25732
    Location:1091 → 1637
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26511
    Location:1831 → 2676
    Neuromodulin_N; Gap junction protein N-terminal region
    cl27652
    Location:3080 → 3118
    Plectin; Plectin repeat

  8. XM_021468115.1 → XP_021323790.1  plectin isoform X16

    UniProtKB/TrEMBL
    A0A8M9PRQ7
    Conserved Domains (9) summary
    smart00150
    Location:543 → 637
    SPEC; Spectrin repeats
    smart00250
    Location:2793 → 2830
    PLEC; Plectin repeat
    COG5069
    Location:35 → 269
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00176
    Location:638 → 828
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:4062 → 4101
    Plectin; Plectin repeat
    cl17036
    Location:830 → 875
    SH3; Src Homology 3 domain superfamily
    cl25732
    Location:1058 → 1604
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26511
    Location:1798 → 2643
    Neuromodulin_N; Gap junction protein N-terminal region
    cl27652
    Location:3047 → 3085
    Plectin; Plectin repeat

  9. XM_021468117.1 → XP_021323792.1  plectin isoform X18

    UniProtKB/TrEMBL
    A0A8M9P1X0
    Related
    ENSDARP00000150293.1, ENSDART00000182888.1
    Conserved Domains (9) summary
    smart00150
    Location:538 → 632
    SPEC; Spectrin repeats
    smart00250
    Location:2788 → 2825
    PLEC; Plectin repeat
    COG5069
    Location:35 → 264
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00176
    Location:633 → 823
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:4057 → 4096
    Plectin; Plectin repeat
    cl17036
    Location:825 → 870
    SH3; Src Homology 3 domain superfamily
    cl25732
    Location:1053 → 1599
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26511
    Location:1793 → 2638
    Neuromodulin_N; Gap junction protein N-terminal region
    cl27652
    Location:3042 → 3080
    Plectin; Plectin repeat

  10. XM_021468120.1 → XP_021323795.1  plectin isoform X21

    UniProtKB/TrEMBL
    A0A2R8PVX9, A0A8M9PRR5
    Related
    ENSDARP00000145064.1, ENSDART00000188208.1
    Conserved Domains (9) summary
    smart00150
    Location:526 → 620
    SPEC; Spectrin repeats
    smart00250
    Location:2776 → 2813
    PLEC; Plectin repeat
    COG5069
    Location:35 → 252
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00176
    Location:621 → 811
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:4045 → 4084
    Plectin; Plectin repeat
    cl17036
    Location:813 → 858
    SH3; Src Homology 3 domain superfamily
    cl25732
    Location:1041 → 1587
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26511
    Location:1781 → 2626
    Neuromodulin_N; Gap junction protein N-terminal region
    cl27652
    Location:3030 → 3068
    Plectin; Plectin repeat

  11. XM_021468116.1 → XP_021323791.1  plectin isoform X17

    UniProtKB/TrEMBL
    A0A8M9PNG8
    Conserved Domains (9) summary
    smart00150
    Location:538 → 632
    SPEC; Spectrin repeats
    smart00250
    Location:2788 → 2825
    PLEC; Plectin repeat
    COG5069
    Location:35 → 264
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00176
    Location:633 → 823
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:4057 → 4096
    Plectin; Plectin repeat
    cl17036
    Location:825 → 870
    SH3; Src Homology 3 domain superfamily
    cl25732
    Location:1053 → 1599
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26511
    Location:1793 → 2638
    Neuromodulin_N; Gap junction protein N-terminal region
    cl27652
    Location:3042 → 3080
    Plectin; Plectin repeat

  12. XM_021468114.1 → XP_021323789.1  plectin isoform X15

    UniProtKB/TrEMBL
    A0A8M9PGJ1
    Conserved Domains (9) summary
    smart00150
    Location:543 → 637
    SPEC; Spectrin repeats
    smart00250
    Location:2793 → 2830
    PLEC; Plectin repeat
    COG5069
    Location:35 → 269
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00176
    Location:638 → 828
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:4062 → 4101
    Plectin; Plectin repeat
    cl17036
    Location:830 → 875
    SH3; Src Homology 3 domain superfamily
    cl25732
    Location:1058 → 1604
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26511
    Location:1798 → 2643
    Neuromodulin_N; Gap junction protein N-terminal region
    cl27652
    Location:3047 → 3085
    Plectin; Plectin repeat

  13. XM_021468119.1 → XP_021323794.1  plectin isoform X20

    UniProtKB/TrEMBL
    A0A8M9PGJ7
    Conserved Domains (9) summary
    smart00150
    Location:532 → 626
    SPEC; Spectrin repeats
    smart00250
    Location:2782 → 2819
    PLEC; Plectin repeat
    COG5069
    Location:19 → 258
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00176
    Location:627 → 817
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:4051 → 4090
    Plectin; Plectin repeat
    cl17036
    Location:819 → 864
    SH3; Src Homology 3 domain superfamily
    cl25732
    Location:1047 → 1593
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26511
    Location:1787 → 2632
    Neuromodulin_N; Gap junction protein N-terminal region
    cl27652
    Location:3036 → 3074
    Plectin; Plectin repeat

  14. XM_021468113.1 → XP_021323788.1  plectin isoform X14

    UniProtKB/TrEMBL
    A0A8M9PB27
    Related
    ENSDARP00000156014.1, ENSDART00000185370.1
    Conserved Domains (9) summary
    smart00150
    Location:545 → 639
    SPEC; Spectrin repeats
    smart00250
    Location:2795 → 2832
    PLEC; Plectin repeat
    COG5069
    Location:37 → 271
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00176
    Location:640 → 830
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:4064 → 4103
    Plectin; Plectin repeat
    cl17036
    Location:832 → 877
    SH3; Src Homology 3 domain superfamily
    cl25732
    Location:1060 → 1606
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26511
    Location:1800 → 2645
    Neuromodulin_N; Gap junction protein N-terminal region
    cl27652
    Location:3049 → 3087
    Plectin; Plectin repeat

  15. XM_021468110.1 → XP_021323785.1  plectin isoform X11

    UniProtKB/TrEMBL
    A0A8M9PRQ0
    Conserved Domains (9) summary
    smart00150
    Location:550 → 644
    SPEC; Spectrin repeats
    smart00250
    Location:2800 → 2837
    PLEC; Plectin repeat
    COG5069
    Location:37 → 276
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00176
    Location:645 → 835
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:4069 → 4108
    Plectin; Plectin repeat
    cl17036
    Location:837 → 882
    SH3; Src Homology 3 domain superfamily
    cl25732
    Location:1065 → 1611
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26511
    Location:1805 → 2650
    Neuromodulin_N; Gap junction protein N-terminal region
    cl27652
    Location:3054 → 3092
    Plectin; Plectin repeat

  16. XM_021468112.1 → XP_021323787.1  plectin isoform X13

    UniProtKB/TrEMBL
    A0A2R8RIJ1, A0A8M9P1W8
    Related
    ENSDARP00000145708.1, ENSDART00000179856.1
    Conserved Domains (9) summary
    smart00150
    Location:545 → 639
    SPEC; Spectrin repeats
    smart00250
    Location:2795 → 2832
    PLEC; Plectin repeat
    COG5069
    Location:49 → 271
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00176
    Location:640 → 830
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:4064 → 4103
    Plectin; Plectin repeat
    cl17036
    Location:832 → 877
    SH3; Src Homology 3 domain superfamily
    cl25732
    Location:1060 → 1606
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26511
    Location:1800 → 2645
    Neuromodulin_N; Gap junction protein N-terminal region
    cl27652
    Location:3049 → 3087
    Plectin; Plectin repeat

  17. XM_021468108.1 → XP_021323783.1  plectin isoform X9

    UniProtKB/TrEMBL
    A0A8M9PB23
    Conserved Domains (9) summary
    smart00150
    Location:557 → 651
    SPEC; Spectrin repeats
    smart00250
    Location:2807 → 2844
    PLEC; Plectin repeat
    COG5069
    Location:49 → 283
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00176
    Location:652 → 842
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:4076 → 4115
    Plectin; Plectin repeat
    cl17036
    Location:844 → 889
    SH3; Src Homology 3 domain superfamily
    cl25732
    Location:1072 → 1618
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26511
    Location:1812 → 2657
    Neuromodulin_N; Gap junction protein N-terminal region
    cl27652
    Location:3061 → 3099
    Plectin; Plectin repeat

  18. XM_021468107.1 → XP_021323782.1  plectin isoform X8

    UniProtKB/TrEMBL
    A0A8M9P1W5
    Conserved Domains (9) summary
    smart00150
    Location:562 → 656
    SPEC; Spectrin repeats
    smart00250
    Location:2812 → 2849
    PLEC; Plectin repeat
    COG5069
    Location:49 → 288
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00176
    Location:657 → 847
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:4081 → 4120
    Plectin; Plectin repeat
    cl17036
    Location:849 → 894
    SH3; Src Homology 3 domain superfamily
    cl25732
    Location:1077 → 1623
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26511
    Location:1817 → 2662
    Neuromodulin_N; Gap junction protein N-terminal region
    cl27652
    Location:3066 → 3104
    Plectin; Plectin repeat

  19. XM_021468118.1 → XP_021323793.1  plectin isoform X19

    UniProtKB/TrEMBL
    A0A8M9PB30
    Conserved Domains (9) summary
    smart00150
    Location:534 → 628
    SPEC; Spectrin repeats
    smart00250
    Location:2784 → 2821
    PLEC; Plectin repeat
    COG5069
    Location:43 → 260
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00176
    Location:629 → 819
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:4053 → 4092
    Plectin; Plectin repeat
    cl17036
    Location:821 → 866
    SH3; Src Homology 3 domain superfamily
    cl25732
    Location:1049 → 1595
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26511
    Location:1789 → 2634
    Neuromodulin_N; Gap junction protein N-terminal region
    cl27652
    Location:3038 → 3076
    Plectin; Plectin repeat

  20. XM_021468111.1 → XP_021323786.1  plectin isoform X12

    UniProtKB/TrEMBL
    A0A8M9PNG2
    Conserved Domains (9) summary
    smart00150
    Location:546 → 640
    SPEC; Spectrin repeats
    smart00250
    Location:2796 → 2833
    PLEC; Plectin repeat
    COG5069
    Location:43 → 272
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00176
    Location:641 → 831
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:4065 → 4104
    Plectin; Plectin repeat
    cl17036
    Location:833 → 878
    SH3; Src Homology 3 domain superfamily
    cl25732
    Location:1061 → 1607
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26511
    Location:1801 → 2646
    Neuromodulin_N; Gap junction protein N-terminal region
    cl27652
    Location:3050 → 3088
    Plectin; Plectin repeat

  21. XM_021468109.1 → XP_021323784.1  plectin isoform X10

    UniProtKB/TrEMBL
    A0A8M9PGI7
    Conserved Domains (9) summary
    smart00150
    Location:551 → 645
    SPEC; Spectrin repeats
    smart00250
    Location:2801 → 2838
    PLEC; Plectin repeat
    COG5069
    Location:43 → 277
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00176
    Location:646 → 836
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:4070 → 4109
    Plectin; Plectin repeat
    cl17036
    Location:838 → 883
    SH3; Src Homology 3 domain superfamily
    cl25732
    Location:1066 → 1612
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26511
    Location:1806 → 2651
    Neuromodulin_N; Gap junction protein N-terminal region
    cl27652
    Location:3055 → 3093
    Plectin; Plectin repeat
Nucleotide Protein Strain
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