tcnbb transcobalamin beta b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tcnbbprovided by ZNC
Official Full Name: transcobalamin beta bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-12
See related: Ensembl:ENSDARG00000091996 AllianceGenome:ZFIN:ZDB-GENE-030131-12
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zeh0098; hm:zeh0098; si:ch211-117m20.5
Summary: Enables cobalamin binding activity. Acts upstream of or within cellular response to xenobiotic stimulus. Predicted to be active in extracellular space. Is expressed in head; integument; and pharynx. Human ortholog(s) of this gene implicated in congenital intrinsic factor deficiency and pernicious anemia. Orthologous to human CBLIF (cobalamin binding intrinsic factor) and TCN1 (transcobalamin 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 5

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (30614532..30615751, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (30014379..30015598, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fk94c05.x1 (e-PCR)
- UniSTS:201758

fl01e07.x1 (e-PCR)
- UniSTS:201844

AI353148 (e-PCR)
- UniSTS:206768

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cobalamin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: transcobalamin beta b

Names: transcobalamin-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001252649.1 → NP_001239578.1 transcobalamin beta b precursor

Status: VALIDATED

Source sequence(s)

EH579542

UniProtKB/TrEMBL

A0A8M1P479, A2BFS9

Related

ENSDARP00000114787.1, ENSDART00000147769.2

Conserved Domains (1) summary

pfam14478
Location:67 → 141

DUF4430; Domain of unknown function (DUF4430)