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Mgst1 microsomal glutathione S-transferase 1 [ Mus musculus (house mouse) ]

Gene ID: 56615, updated on 21-Apr-2024

Summary

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Official Symbol
Mgst1provided by MGI
Official Full Name
microsomal glutathione S-transferase 1provided by MGI
Primary source
MGI:MGI:1913850
See related
Ensembl:ENSMUSG00000008540 AllianceGenome:MGI:1913850
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gst; 1500002K10Rik
Summary
Enables glutathione transferase activity. Acts upstream of or within glutathione metabolic process. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; brain; respiratory system; sensory organ; and urinary system. Orthologous to human MGST1 (microsomal glutathione S-transferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 1165.6), liver E18 (RPKM 396.4) and 9 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 G1; 6 68.4 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (138117525..138133753)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (138140527..138156755)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38552 Neighboring gene STARR-seq mESC enhancer starr_17634 Neighboring gene STARR-seq mESC enhancer starr_17635 Neighboring gene solute carrier family 15, member 5 Neighboring gene STARR-positive B cell enhancer mm9_chr6:138096406-138096707 Neighboring gene predicted gene, 30213 Neighboring gene RIKEN cDNA A830011K09 gene Neighboring gene LIM domain only 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression level and DNA methylation status of glutathione-S-transferase genes in normal murine prostate and TRAMP tumors. Mavis CK, et al. Prostate, 2009 Sep 1. PMID 19444856, Free PMC Article
  2. Structural organization of the murine microsomal glutathione S-transferase gene (MGST1) from the 129/SvJ strain: identification of the promoter region and a comprehensive examination of tissue expression. Kelner MJ, et al. Biochim Biophys Acta, 2004 May 25. PMID 15157743
  3. Microsomal glutathione S-transferase 1 in the retinal pigment epithelium: protection against oxidative stress and a potential role in aging. Maeda A, et al. Biochemistry, 2005 Jan 18. PMID 15641772, Free PMC Article
  4. Cloning, characterisation and bacterial expression of full length cDNA for the mouse liver microsomal glutathione S-transferase. Raza H, et al. Oncol Rep, 2000 May-Jun. PMID 10767383
  5. MGST1, a GSH transferase/peroxidase essential for development and hematopoietic stem cell differentiation. Bräutigam L, et al. Redox Biol, 2018 Jul. PMID 29702404, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A role for microsomal glutathione transferase 1 in melanin biosynthesis and melanoma progression.
    Title: A role for microsomal glutathione transferase 1 in melanin biosynthesis and melanoma progression.
  2. The impact of MGST1 on hematopoiesis was also shown in hematopoietic stem/progenitor cells (HSPC) isolated from mice, where it was expressed at high levels. Upon promoting HSPC differentiation, lentiviral shRNA MGST1 knockdown significantly reduced differentiated, dedicated cells of the hematopoietic system.
    Title: MGST1, a GSH transferase/peroxidase essential for development and hematopoietic stem cell differentiation.
  3. Gst genes are extensively downregulated in primary but not metastatic TRAMP tumors.
    Title: Expression level and DNA methylation status of glutathione-S-transferase genes in normal murine prostate and TRAMP tumors.
  4. MGST1 is a dominant, highly expressed enzyme in mouse retinal pigment epithelium (RPE) microsomes that displays an important protective function against oxidative insult in the RPE that decreases with age.
    Title: Microsomal glutathione S-transferase 1 in the retinal pigment epithelium: protection against oxidative stress and a potential role in aging.
  5. identification of the promoter region and a comprehensive examination of tissue expression of MGST1
    Title: Structural organization of the murine microsomal glutathione S-transferase gene (MGST1) from the 129/SvJ strain: identification of the promoter region and a comprehensive examination of tissue expression.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glutathione binding ISO
Inferred from Sequence Orthology
more info
  
enables glutathione peroxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutathione transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to lipid hydroperoxide ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within glutathione metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glutathione transport ISO
Inferred from Sequence Orthology
more info
  
involved_in response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
  
involved_in response to organonitrogen compound ISO
Inferred from Sequence Orthology
more info
  
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisomal membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
microsomal glutathione S-transferase 1
Names
microsomal GST-1
microsomal GST-I
NP_001334418.1
NP_001348236.1
NP_001348237.1
NP_001348238.1
NP_064330.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347489.2 → NP_001334418.1  microsomal glutathione S-transferase 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region, compared to variant 1. These differences result in translation from an alternate start codon. The encoded isoform (2) has a longer N-terminus, compared to isoform 1.
    Source sequence(s)
    AC121849, AC131766
    Consensus CDS
    CCDS85177.1
    UniProtKB/TrEMBL
    E9QJW0
    Related
    ENSMUSP00000112923.2, ENSMUST00000118091.8

  2. NM_001361307.1 → NP_001348236.1  microsomal glutathione S-transferase 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC121849, AC131766
    Consensus CDS
    CCDS90131.1
    UniProtKB/TrEMBL
    D3YU60
    Related
    ENSMUSP00000112646.2, ENSMUST00000120939.8

  3. NM_001361308.1 → NP_001348237.1  microsomal glutathione S-transferase 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC121849, AC131766
    Consensus CDS
    CCDS20668.1
    UniProtKB/Swiss-Prot
    Q91VS7, Q9CQ57, Q9R191
    UniProtKB/TrEMBL
    Q53ZD4
    Related
    ENSMUSP00000113257.2, ENSMUST00000120302.8
    Conserved Domains (1) summary
    pfam01124
    Location:19 → 150
    MAPEG; MAPEG family

  4. NM_001361309.1 → NP_001348238.1  microsomal glutathione S-transferase 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC121849, AC131766
    Consensus CDS
    CCDS20668.1
    UniProtKB/Swiss-Prot
    Q91VS7, Q9CQ57, Q9R191
    UniProtKB/TrEMBL
    Q53ZD4
    Related
    ENSMUSP00000113859.2, ENSMUST00000120230.8
    Conserved Domains (1) summary
    pfam01124
    Location:19 → 150
    MAPEG; MAPEG family

  5. NM_019946.5 → NP_064330.2  microsomal glutathione S-transferase 1 isoform 1

    See identical proteins and their annotated locations for NP_064330.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the shorter isoform (1).
    Source sequence(s)
    AC121849, AC131766, AK005122
    Consensus CDS
    CCDS20668.1
    UniProtKB/Swiss-Prot
    Q91VS7, Q9CQ57, Q9R191
    UniProtKB/TrEMBL
    Q53ZD4
    Related
    ENSMUSP00000008684.5, ENSMUST00000008684.11
    Conserved Domains (1) summary
    pfam01124
    Location:19 → 150
    MAPEG; MAPEG family

RNA

  1. NR_154597.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC121849, AC131766

  2. NR_154598.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC121849, AC131766
    Related
    ENSMUST00000140932.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    138117525..138133753
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91VS7.3 GenPept UniProtKB/Swiss-Prot:Q91VS7

Gene LinkOut

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