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Srpk3 serine/arginine-rich protein specific kinase 3 [ Mus musculus (house mouse) ]

Gene ID: 56504, updated on 3-Apr-2024

Summary

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Official Symbol
Srpk3provided by MGI
Official Full Name
serine/arginine-rich protein specific kinase 3provided by MGI
Primary source
MGI:MGI:1891338
See related
Ensembl:ENSMUSG00000002007 AllianceGenome:MGI:1891338
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mssk1; Stk23
Summary
Enables protein serine/threonine kinase activity. Involved in muscle tissue development. Acts upstream of or within protein phosphorylation and skeletal muscle tissue development. Predicted to be active in cytoplasm and nucleus. Is expressed in tail mesenchyme; tongue; and vertebral axis musculature. Orthologous to human SRPK3 (SRSF protein kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 23.8), heart adult (RPKM 14.3) and 12 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X A7.3; X 37.41 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (72818011..72822531)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (73772608..73778925)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 25226 Neighboring gene plexin B3 Neighboring gene isocitrate dehydrogenase 3 (NAD+), gamma Neighboring gene STARR-positive B cell enhancer ABC_E11049 Neighboring gene signal sequence receptor, delta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Association Between Decreased Srpk3 Expression and Increased Substantia Nigra Alpha-Synuclein Level in an MPTP-Induced Parkinson's Disease Mouse Model. Seo MH, et al. Mol Neurobiol, 2023 Feb. PMID 36369636
  2. Srpk3 Decrease Associated with Alpha-Synuclein Increase in Muscles of MPTP-Induced Parkinson's Disease Mice. Seo MH, et al. Int J Mol Sci, 2021 Aug 29. PMID 34502283, Free PMC Article
  3. Regulation of skeletal muscle sarcomere integrity and postnatal muscle function by Mef2c. Potthoff MJ, et al. Mol Cell Biol, 2007 Dec. PMID 17875930, Free PMC Article
  4. Target gene selectivity of the myogenic basic helix-loop-helix transcription factor myogenin in embryonic muscle. Davie JK, et al. Dev Biol, 2007 Nov 15. PMID 17904117
  5. Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2. Nakagawa O, et al. Genes Dev, 2005 Sep 1. PMID 16140986, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Association Between Decreased Srpk3 Expression and Increased Substantia Nigra Alpha-Synuclein Level in an MPTP-Induced Parkinson's Disease Mouse Model.
    Title: Association Between Decreased Srpk3 Expression and Increased Substantia Nigra Alpha-Synuclein Level in an MPTP-Induced Parkinson's Disease Mouse Model.
  2. Srpk3 Decrease Associated with Alpha-Synuclein Increase in Muscles of MPTP-Induced Parkinson's Disease Mice.
    Title: Srpk3 Decrease Associated with Alpha-Synuclein Increase in Muscles of MPTP-Induced Parkinson's Disease Mice.
  3. normal muscle growth and homeostasis require MEF2-dependent signaling by Srpk3
    Title: Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within muscle organ development IEA
Inferred from Electronic Annotation
more info
  
involved_in muscle tissue development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of mRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within skeletal muscle tissue development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spliceosomal complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
SRSF protein kinase 3
Names
SR-protein-specific kinase 3
muscle-specific serine kinase 1
serine/threonine kinase 23, muscle-specific serine kinase 1 70
serine/threonine-protein kinase 23
serine/threonine-protein kinase SRPK3
NP_001413247.1
NP_062658.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001426318.1 → NP_001413247.1  SRSF protein kinase 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL672094

  2. NM_019684.2 → NP_062658.1  SRSF protein kinase 3 isoform 2

    See identical proteins and their annotated locations for NP_062658.1

    Status: VALIDATED

    Source sequence(s)
    AF043288, BY243709
    Consensus CDS
    CCDS30211.1
    UniProtKB/Swiss-Prot
    Q9Z0G2
    UniProtKB/TrEMBL
    Q0VAW8, Q684J2
    Related
    ENSMUSP00000002081.6, ENSMUST00000002081.6
    Conserved Domains (2) summary
    smart00220
    Location:78 → 563
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14218
    Location:67 → 563
    STKc_SRPK3; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    72818011..72822531
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z0G2.1 GenPept UniProtKB/Swiss-Prot:Q9Z0G2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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