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Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 [ Mus musculus (house mouse) ]

Gene ID: 56448, updated on 11-Apr-2024

Summary

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Official Symbol
Cyp2d22provided by MGI
Official Full Name
cytochrome P450, family 2, subfamily d, polypeptide 22provided by MGI
Primary source
MGI:MGI:1929474
See related
Ensembl:ENSMUSG00000061740 AllianceGenome:MGI:1929474
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2D22
Summary
Predicted to enable heme binding activity and monooxygenase activity. Predicted to be involved in several processes, including C21-steroid hormone metabolic process; arachidonic acid metabolic process; and phenol-containing compound biosynthetic process. Located in cytoplasm. Is expressed in several structures, including genitourinary system; heart; liver; lung; and skeletal muscle. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; acute myeloid leukemia; asthma; autoimmune hepatitis; and rhinitis. Orthologous to several human genes including CYP2D6 (cytochrome P450 family 2 subfamily D member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver adult (RPKM 124.5), duodenum adult (RPKM 32.3) and 17 other tissues See more
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Genomic context

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See Cyp2d22 in Genome Data Viewer
Location:
15 E1; 15 38.57 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (82254728..82264461, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (82370527..82380260, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene PH domain containing endocytic trafficking adaptor 2 Neighboring gene STARR-seq mESC enhancer starr_39293 Neighboring gene single-pass membrane protein with aspartate rich tail 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit A6 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:82192158-82192359 Neighboring gene cytochrome P450, family 2, subfamily d, polypeptide 11 Neighboring gene microRNA 7684 Neighboring gene cytochrome P450, family 2, subfamily d, polypeptide 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The expression of CYP2D22, an ortholog of human CYP2D6, in mouse striatum and its modulation in 1-methyl 4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease phenotype and nicotine-mediated neuroprotection. Singh S, et al. Rejuvenation Res, 2009 Jun. PMID 19594327
  2. Characterization of Cyp2d22, a novel cytochrome P450 expressed in mouse mammary cells. Blume N, et al. Arch Biochem Biophys, 2000 Sep 15. PMID 11032406
  3. Effects of infection of MRSA on the expression and activity of renal cytochrome P450s in mice. Long N, et al. J Toxicol Sci, 2019. PMID 30944282
  4. Molecular evolution of the CYP2D subfamily in primates: purifying selection on substrate recognition sites without the frequent or long-tract gene conversion. Yasukochi Y, et al. Genome Biol Evol, 2015 Mar 25. PMID 25808902, Free PMC Article
  5. Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues. Choudhary D, et al. Arch Biochem Biophys, 2003 Jun 1. PMID 12745259

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Its mRNA expression is decreased by the high level of MRSA, but the low level of MRSA increased its expression.
    Title: Effects of infection of MRSA on the expression and activity of renal cytochrome P450s in mice.
  2. CYP2D22 is expressed in mouse striatum and has a possible role in the MPTP-induced Parkinson's disease phenotype and nicotine-mediated neuroprotection
    Title: The expression of CYP2D22, an ortholog of human CYP2D6, in mouse striatum and its modulation in 1-methyl 4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease phenotype and nicotine-mediated neuroprotection.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Potential readthrough

Included gene: Cyp2d9

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables anandamide 11,12 epoxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables anandamide 14,15 epoxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables anandamide 8,9 epoxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables arachidonic acid monooxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heme binding ISO
Inferred from Sequence Orthology
more info
  
enables monooxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
Inferred from Biological aspect of Ancestor
more info
  
enables progesterone 21-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in C21-steroid hormone metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in arachidonic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in arachidonic acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in dopamine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in dopamine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in oxidative demethylation ISO
Inferred from Sequence Orthology
more info
  
involved_in serotonin biosynthetic process from tryptophan ISO
Inferred from Sequence Orthology
more info
  
involved_in xenobiotic metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in xenobiotic metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cytochrome P450, family 2, subfamily d, polypeptide 22
Names
cytochrome P450, 2d22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163472.1 → NP_001156944.1  cytochrome P450, family 2, subfamily d, polypeptide 22

    See identical proteins and their annotated locations for NP_001156944.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC104325, AC113593, AW494268
    Consensus CDS
    CCDS37159.1
    UniProtKB/TrEMBL
    Q91W87, Q9JKY7
    Related
    ENSMUSP00000023083.8, ENSMUST00000023083.9
    Conserved Domains (1) summary
    pfam00067
    Location:37 → 496
    p450; Cytochrome P450

  2. NM_019823.4 → NP_062797.3  cytochrome P450, family 2, subfamily d, polypeptide 22

    See identical proteins and their annotated locations for NP_062797.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC104325, AC113593, AK090296, AW494268, BX520002, BY297294
    Consensus CDS
    CCDS37159.1
    UniProtKB/TrEMBL
    Q91W87, Q9JKY7
    Conserved Domains (1) summary
    pfam00067
    Location:37 → 496
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    82254728..82264461 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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