U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

arhgap12a Rho GTPase activating protein 12a [ Danio rerio (zebrafish) ]

Gene ID: 563267, updated on 27-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
arhgap12aprovided by ZNC
Official Full Name
Rho GTPase activating protein 12aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050809-38
See related
Ensembl:ENSDARG00000008548 AllianceGenome:ZFIN:ZDB-GENE-050809-38
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
im:7153489; si:ch211-159p3.3
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in regulation of GTPase activity. Predicted to act upstream of or within signal transduction. Predicted to be active in cytoplasm. Is expressed in ectoderm. Orthologous to human ARHGAP12 (Rho GTPase activating protein 12). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See arhgap12a in Genome Data Viewer
Location:
chromosome: 2
Exon count:
21
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (43749187..43797223)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (43896185..43944225)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene kinesin family member 5B, a Neighboring gene finTRIM family, member 16 Neighboring gene zinc finger E-box binding homeobox 1a Neighboring gene NOD-like receptor family B, member 5

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Evolutionary recruitment of flexible Esrp-dependent splicing programs into diverse embryonic morphogenetic processes. Burguera D, et al. Nat Commun, 2017 Nov 27. PMID 29180615, Free PMC Article
  2. Regulation of posterior body and epidermal morphogenesis in zebrafish by localized Yap1 and Wwtr1. Kimelman D, et al. Elife, 2017 Dec 28. PMID 29283341, Free PMC Article
  3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell development IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in system development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
rho GTPase activating protein 12a; rho GTPase-activating protein 12a

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001126407.1 → NP_001119879.1  rho GTPase-activating protein 12a

    Status: PROVISIONAL

    Source sequence(s)
    CR457482
    UniProtKB/TrEMBL
    A0A8M1NHD5, F6P057
    Related
    ENSDARP00000122140.1, ENSDART00000142804.3
    Conserved Domains (6) summary
    cd12070
    Location:11 → 70
    SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
    cd04403
    Location:638 → 824
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:448 → 558
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:462 → 559
    PH; PH domain
    pfam00397
    Location:252 → 278
    WW; WW domain
    pfam16618
    Location:67 → 233
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    43749187..43797223
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021480748.1 → XP_021336423.1  rho GTPase activating protein 12a isoform X1

    UniProtKB/TrEMBL
    A0A8M9QA49
    Conserved Domains (5) summary
    cd12070
    Location:11 → 70
    SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
    cd04403
    Location:660 → 846
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:470 → 580
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00397
    Location:252 → 278
    WW; WW domain
    pfam16618
    Location:67 → 233
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

  2. XM_005171385.4 → XP_005171442.1  rho GTPase activating protein 12a isoform X2

    UniProtKB/TrEMBL
    A0A8M2BIT3
    Conserved Domains (6) summary
    cd12070
    Location:11 → 70
    SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
    cd04403
    Location:632 → 818
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:442 → 552
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:456 → 553
    PH; PH domain
    pfam00397
    Location:252 → 278
    WW; WW domain
    pfam16618
    Location:67 → 233
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

  3. XM_021480763.1 → XP_021336438.1  rho GTPase activating protein 12a isoform X3

    UniProtKB/TrEMBL
    A0A8M9QA59
    Conserved Domains (5) summary
    cd12070
    Location:11 → 70
    SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
    cd04403
    Location:616 → 802
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:426 → 536
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00397
    Location:252 → 278
    WW; WW domain
    pfam16618
    Location:67 → 233
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

  4. XM_021480770.1 → XP_021336445.1  rho GTPase activating protein 12a isoform X6

    UniProtKB/TrEMBL
    A0A8M9QNP2
    Conserved Domains (5) summary
    cd12070
    Location:11 → 70
    SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
    cd04403
    Location:583 → 769
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:393 → 503
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00397
    Location:252 → 278
    WW; WW domain
    pfam16618
    Location:67 → 233
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

  5. XM_005171386.4 → XP_005171443.1  rho GTPase activating protein 12a isoform X4

    UniProtKB/TrEMBL
    A0A8M2BIQ0
    Conserved Domains (6) summary
    cd12070
    Location:11 → 70
    SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
    cd04403
    Location:610 → 796
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:420 → 530
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:434 → 531
    PH; PH domain
    pfam00397
    Location:252 → 278
    WW; WW domain
    pfam16618
    Location:67 → 233
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

  6. XM_005171388.4 → XP_005171445.1  rho GTPase activating protein 12a isoform X5

    UniProtKB/TrEMBL
    A0A8M2BJ65
    Conserved Domains (6) summary
    cd12070
    Location:11 → 70
    SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
    cd04403
    Location:588 → 774
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:398 → 508
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:412 → 509
    PH; PH domain
    pfam00397
    Location:252 → 278
    WW; WW domain
    pfam16618
    Location:67 → 233
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

  7. XM_021480754.1 → XP_021336429.1  rho GTPase activating protein 12a isoform X1

    UniProtKB/TrEMBL
    A0A8M9QA49
    Conserved Domains (5) summary
    cd12070
    Location:11 → 70
    SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
    cd04403
    Location:660 → 846
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:470 → 580
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00397
    Location:252 → 278
    WW; WW domain
    pfam16618
    Location:67 → 233
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

  8. XM_021480772.1 → XP_021336447.1  rho GTPase activating protein 12a isoform X7

    UniProtKB/TrEMBL
    A0A8M9PYG1
    Conserved Domains (4) summary
    cd04403
    Location:455 → 641
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:265 → 375
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00397
    Location:47 → 73
    WW; WW domain
    pfam16618
    Location:10 → 28
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

  9. XM_021480774.1 → XP_021336449.1  rho GTPase activating protein 12a isoform X8

    UniProtKB/TrEMBL
    A0A8M9QFU9
    Conserved Domains (4) summary
    cd04403
    Location:433 → 619
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:243 → 353
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00397
    Location:47 → 73
    WW; WW domain
    pfam16618
    Location:10 → 28
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Tools