Acp3 acid phosphatase 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Acp3provided by MGI
Official Full Name: acid phosphatase 3provided by MGI
Primary source: MGI:MGI:1928480
See related: Ensembl:ENSMUSG00000032561 AllianceGenome:MGI:1928480
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lap; PAP; Acpp; FRAP; Ppal; 5'-NT; A030005E02Rik
Summary: Enables thiamine phosphate phosphatase activity. Involved in nucleobase-containing small molecule metabolic process; regulation of sensory perception of pain; and thiamine metabolic process. Located in filopodium; plasma membrane; and vesicle membrane. Is integral component of membrane. Is expressed in epithelium of phallic urethra of female; epithelium of phallic urethra of male; genital tubercle mesenchyme of female; and urethral plate. Used to study prostate cancer. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human ACP3 (acid phosphatase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in genital fat pad adult (RPKM 3.4), adrenal adult (RPKM 2.3) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F1; 9 56.61 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (104165439..104214921, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (104288240..104337722, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PAP-immunoreactivity was present in type I and one of type III taste cells of taste buds. Thus, it is suggested that PAP might be a responsible ectoenzyme for metabolism of extracellular nucleotides, being involved in the regulation of taste signaling in taste buds.
Title: Expression of Prostatic Acid Phosphatase in Rat Circumvallate Papillae.
These findings demonstrate that PAP secreted by PCa cells in OB bone metastases increases osteoprotegerin and plays a critical role in the vicious cross talk between cancer and bone cells.
Title: Prostatic Acid Phosphatase Alters the RANKL/OPG System and Induces Osteoblastic Prostate Cancer Bone Metastases.
functional PAP(thorn) neurons are essential for the analgesic effect, which is mediated by NGF-trkA signaling.
Title: EXPRESS: NGF-trkA signaling modulates the analgesic effects of prostatic acid phosphatase in resiniferatoxin-induced neuropathy.
TMPAP is involved in the control of GABAergic tone in the brain also through exocytosis, and that PAP deficiency produces a distinct neurological phenotype.
Title: Mice deficient in transmembrane prostatic acid phosphatase display increased GABAergic transmission and neurological alterations.
In male mouse saliva prostatic acid phosphatase regulates salivation.
Title: Prostatic acid phosphatase is the main acid phosphatase with 5'-ectonucleotidase activity in the male mouse saliva and regulates salivation.
Data indicate that prostate acid phosphatase-based peptide vaccine PAP-114-128 peptide appears to be a relevant for the treatment of prostate cancer.
Title: Novel prostate acid phosphatase-based peptide vaccination strategy induces antigen-specific T-cell responses and limits tumour growth in mice.
this PAP-/- mouse model shows that TMPAP is required for the normal function of prostate in mice, and its deficiency leads to prostate adenocarcinoma.
Title: Transmembrane prostatic acid phosphatase (TMPAP) interacts with snapin and deficient mice develop prostate adenocarcinoma.
Both prostatic acid phosphatase and ecto-5'-nucleotidase generate adenosine in the dorsal spinal cord.
Title: Tissue-nonspecific alkaline phosphatase acts redundantly with PAP and NT5E to generate adenosine in the dorsal spinal cord.
Prostatic acid phosphatase is required for the antinociceptive effects of thiamine and benfotiamine.
Title: Prostatic acid phosphatase is required for the antinociceptive effects of thiamine and benfotiamine.
Experiments indicate that PAP and NT5E are the main ectonucleotidases that generate adenosine in nociceptive circuits and indicate these enzymes transform pulsatile or sustained nucleotide release into an inhibitory adenosinergic signal.
Title: PAP and NT5E inhibit nociceptive neurotransmission by rapidly hydrolyzing nucleotides to adenosine.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D9Dcr54 (e-PCR), detects polymorphism
- UniSTS:498977

BE553816 (e-PCR)
- UniSTS:208438

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

Acpp (e-PCR), detects polymorphism
- UniSTS:527236

D9Mgc31 (e-PCR), detects polymorphism
- UniSTS:142772

AI324033 (e-PCR)
- UniSTS:179964

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 5'-nucleotidase activity	ISO Inferred from Sequence Orthology more info
enables XMP 5'-nucleosidase activity	IEA Inferred from Electronic Annotation more info
enables acid phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acid phosphatase activity	ISO Inferred from Sequence Orthology more info
enables acid phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables choline binding	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lysophosphatidic acid phosphatase activity	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables thiamine phosphate phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in adenosine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in adenosine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in dephosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lysosome organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleotide metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of adenosine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in purine nucleobase metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in thiamine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi cisterna	ISO Inferred from Sequence Orthology more info
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in filopodium	IDA Inferred from Direct Assay more info	PubMed
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in multivesicular body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in secretory granule	ISO Inferred from Sequence Orthology more info
located_in vesicle membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: prostatic acid phosphatase

Names: 5'-nucleotidase; TMPase; acid phosphatase, prostate; ecto-5'-nucleotidase; fluoride-resistant acid phosphatase; lysosomal acid phosphatase; protein tyrosine phosphatase ACP3; thiamine monophosphatase

NP_062781.2

EC 3.1.3.2

EC 3.1.3.48

EC 3.1.3.5

NP_997551.1

EC 3.1.3.2

EC 3.1.3.48

EC 3.1.3.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019807.2 → NP_062781.2 prostatic acid phosphatase isoform 2 precursor

See identical proteins and their annotated locations for NP_062781.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate 3' terminal exon compared to variant 1. The encoded isoform (2, also known as PAP) is shorter and has a distinct C-terminus compared to isoform 1. This isoform is a secreted protein.

Source sequence(s)

AK029273, AK076383, CD770300

Consensus CDS

CCDS40750.1

UniProtKB/Swiss-Prot

A4QPG2, B8JJZ5, B8JJZ6, Q8C682, Q8CE08, Q9QXH7

Related

ENSMUSP00000108209.3, ENSMUST00000112590.3

Conserved Domains (1) summary

cd07061
Location:33 → 331

HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction
NM_207668.2 → NP_997551.1 prostatic acid phosphatase isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1, also known as TM-PAP). This isoform is a transmembrane protein.

Source sequence(s)

AC127422, AK029273, AK076383

Consensus CDS

CCDS23460.1

UniProtKB/Swiss-Prot

Q8CE08

Related

ENSMUSP00000059889.7, ENSMUST00000062723.14

Conserved Domains (1) summary

cd07061
Location:33 → 331

HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction