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tmem108 transmembrane protein 108 [ Danio rerio (zebrafish) ]

Gene ID: 563089, updated on 27-Mar-2024

Summary

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Official Symbol
tmem108provided by ZNC
Official Full Name
transmembrane protein 108provided by ZNC
Primary source
ZFIN:ZDB-GENE-091204-397
See related
Ensembl:ENSDARG00000090230 AllianceGenome:ZFIN:ZDB-GENE-091204-397
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch211-149n12.2
Summary
Predicted to be involved in dendrite extension; postsynaptic density organization; and retrograde axonal transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in axon; endosome; and postsynaptic density. Orthologous to human TMEM108 (transmembrane protein 108). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 24
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (9744008..9874689)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (9603490..9734303)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene ubiquitin-like modifier activating enzyme 5 Neighboring gene DNA topoisomerase II binding protein 1 Neighboring gene carnitine deficiency-associated gene expressed in ventricle 3 Neighboring gene VPS41 subunit of HOPS complex

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. TopBP1 Governs Hematopoietic Stem/Progenitor Cells Survival in Zebrafish Definitive Hematopoiesis. Gao L, et al. PLoS Genet, 2015 Jul. PMID 26131719, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in dendrite extension IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in postsynaptic density organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde axonal transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transmembrane protein 108

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    9744008..9874689
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009297307.3 → XP_009295582.1  transmembrane protein 108 isoform X2

    UniProtKB/TrEMBL
    A0A8M3AP50
    Conserved Domains (1) summary
    pfam15759
    Location:13 → 483
    TMEM108; TMEM108 family

  2. XM_005162593.4 → XP_005162650.1  transmembrane protein 108 isoform X1

    UniProtKB/TrEMBL
    A0A8M2B9F3, E7FAE6
    Related
    ENSDARP00000110325.2, ENSDART00000129656.3
    Conserved Domains (1) summary
    pfam15759
    Location:13 → 524
    TMEM108; TMEM108 family

  3. XM_005162594.3 → XP_005162651.1  transmembrane protein 108 isoform X3

    UniProtKB/TrEMBL
    A0A8M2B9L7
    Conserved Domains (1) summary
    pfam15759
    Location:1 → 493
    TMEM108; TMEM108 family
Nucleotide Protein
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