gigyf2 GRB10 interacting GYF protein 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gigyf2provided by ZNC
Official Full Name: GRB10 interacting GYF protein 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-050706-185
See related: Ensembl:ENSDARG00000009735 AllianceGenome:ZFIN:ZDB-GENE-050706-185
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: gigfy2; fb57e02; im:6911549; wu:fb57e02; zgc:111944
Summary: Predicted to be involved in insulin-like growth factor receptor signaling pathway. Predicted to be active in several cellular components, including cytosol; perikaryon; and proximal dendrite. Is expressed in blastoderm; blastodisc; brain; and somite. Used to study schizophrenia. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human GIGYF2 (GRB10 interacting GYF protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (48203193..48255906, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (48349027..48401701, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb57e02.x1 (e-PCR)
- UniSTS:190773

fb57e02 (e-PCR)
- UniSTS:187231

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in insulin-like growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in perikaryon	IBA Inferred from Biological aspect of Ancestor more info
is_active_in proximal dendrite	IBA Inferred from Biological aspect of Ancestor more info
is_active_in vesicle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: GRB10-interacting GYF protein 2

Names: PERQ amino acid-rich with GYF domain-containing protein 2; trinucleotide repeat-containing gene 15 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001030161.2 → NP_001025332.2 GRB10-interacting GYF protein 2

Status: VALIDATED

Source sequence(s)

BX677676, BX890560, BX890608

UniProtKB/Swiss-Prot

B0S7J5, Q4KME6

Related

ENSDARP00000056276.5, ENSDART00000056277.6

Conserved Domains (1) summary

smart00444
Location:557 → 612

GYF; Contains conserved Gly-Tyr-Phe residues