Cts7 cathepsin 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cts7provided by MGI
Official Full Name: cathepsin 7provided by MGI
Primary source: MGI:MGI:1860262
See related: Ensembl:ENSMUSG00000021440 AllianceGenome:MGI:1860262
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CTS1; Epcs24; Epcs71
Summary: Predicted to enable several functions, including collagen binding activity; fibronectin binding activity; and serpin family protein binding activity. Acts upstream of or within negative regulation of mitotic cell cycle and trophoblast giant cell differentiation. Located in several cellular components, including Golgi apparatus; endosome; and lysosome. Is expressed in embryo; extraembryonic component; heart; placenta; and primary trophoblast giant cell. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to human CTSL (cathepsin L). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 13 B2; 13 32.71 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (61500275..61506010, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (61352461..61358196, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Disruption of IRE1alpha and XBP1 drastically attenuated the expression of Cts7 and Cts8, which are essential cathepsins for placenta formation.
Title: Positive contribution of IRE1α-XBP1 pathway to the expression of placental cathepsins.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

General gene information

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Markers

RH118353 (e-PCR)
- UniSTS:123954

RH124794 (e-PCR)
- UniSTS:161616

Cts7-ps (e-PCR), detects polymorphism
- UniSTS:256884

Cts7 (e-PCR), detects polymorphism
- UniSTS:166282

RH125784 (e-PCR)
- UniSTS:162531

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase activator activity involved in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	ISA Inferred from Sequence Alignment more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of peptidase activity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis	ISA Inferred from Sequence Alignment more info	PubMed
involved_in proteolysis involved in protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within trophoblast giant cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cathepsin 7

Names: cathepsin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001359387.1 → NP_001346316.1 cathepsin 7 preproprotein

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AY014779, BC064740, CT030645

Consensus CDS

CCDS26588.1

UniProtKB/Swiss-Prot

Q91ZF2, Q9JI84

UniProtKB/TrEMBL

A0A286YDP3

Related

ENSMUSP00000153603.2, ENSMUST00000224986.2

Conserved Domains (2) summary

smart00848
Location:29 → 87

Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

cd02248
Location:113 → 329

Peptidase_C1A; Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences, ...
NM_019539.4 → NP_062412.1 cathepsin 7 preproprotein

See identical proteins and their annotated locations for NP_062412.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

BC064740, CA536242, CT030645

Consensus CDS

CCDS26588.1

UniProtKB/Swiss-Prot

Q91ZF2, Q9JI84

UniProtKB/TrEMBL

A0A286YDP3

Related

ENSMUSP00000021892.6, ENSMUST00000021892.7

Conserved Domains (2) summary

smart00848
Location:29 → 87

Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

cd02248
Location:113 → 329

Peptidase_C1A; Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences, ...