naga N-acetylgalactosaminidase, alpha [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nagaprovided by ZNC
Official Full Name: N-acetylgalactosaminidase, alphaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-051113-256
See related: Ensembl:ENSDARG00000099313 AllianceGenome:ZFIN:ZDB-GENE-051113-256
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:123333
Summary: Predicted to enable alpha-galactosidase activity. Predicted to be involved in glycoside catabolic process; glycosylceramide catabolic process; and oligosaccharide metabolic process. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be located in lysosome. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Kanzaki disease; Schindler disease type 1; angiokeratoma; and neuroaxonal dystrophy. Orthologous to human NAGA (alpha-N-acetylgalactosaminidase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (985960..1007676, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (972512..978700, complement)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables alpha-galactosidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on glycosyl bonds	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, hydrolyzing O-glycosyl compounds	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycoside catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within metabolic process	IEA Inferred from Electronic Annotation more info
involved_in oligosaccharide metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: alpha-N-acetylgalactosaminidase

NP_001032465.2

EC 3.2.1.49

XP_021330719.1

EC 3.2.1.49

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037388.2 → NP_001032465.2 alpha-N-acetylgalactosaminidase precursor

Status: VALIDATED

Source sequence(s)

EH434772, EH453970, EH479732, FO904962

UniProtKB/TrEMBL

A0A0R4IJL2, A0A8M1N7Y2

Related

ENSDARP00000134512.1, ENSDART00000160902.2

Conserved Domains (1) summary

cl07893
Location:25 → 394

AmyAc_family; Alpha amylase catalytic domain family

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007115.7 Reference GRCz11 Primary Assembly

Range

985960..1007676 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021475044.1 → XP_021330719.1 alpha-N-acetylgalactosaminidase isoform X1

UniProtKB/TrEMBL

A0A0R4IJL2, A0A8M1N7Y2

Conserved Domains (1) summary

cl07893
Location:25 → 394

AmyAc_family; Alpha amylase catalytic domain family