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adgrl3.1 adhesion G protein-coupled receptor L3.1 [ Danio rerio (zebrafish) ]

Gene ID: 560631, updated on 11-Apr-2024

Summary

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Official Symbol
adgrl3.1provided by ZNC
Official Full Name
adhesion G protein-coupled receptor L3.1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-7856
See related
Ensembl:ENSDARG00000061121 AllianceGenome:ZFIN:ZDB-GENE-030131-7856
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
lphn3; lphn3.1; wu:fj36g07; si:ch211-209p5.2
Summary
Predicted to enable G protein-coupled receptor activity and carbohydrate binding activity. Acts upstream of or within cellular response to estrogen stimulus and locomotory behavior. Predicted to be located in axon and plasma membrane. Predicted to be integral component of membrane. Is expressed in several structures, including central nervous system; eye; heart; liver; and ovary. Orthologous to human ADGRL3 (adhesion G protein-coupled receptor L3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See adgrl3.1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
24
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (22943546..23157716, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (22252810..22467012, complement)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene quinoid dihydropteridine reductase b, tandem duplicate 1 Neighboring gene general transcription factor IIE, polypeptide 2, beta Neighboring gene small integral membrane protein 18 Neighboring gene si:dkey-92j12.5 Neighboring gene replication factor C (activator 1) 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Pharmacological analysis of zebrafish lphn3.1 morphant larvae suggests that saturated dopaminergic signaling could underlie the ADHD-like locomotor hyperactivity. Lange M, et al. Prog Neuropsychopharmacol Biol Psychiatry, 2018 Jun 8. PMID 29496512, Free PMC Article
  2. Developmental exposure to acetaminophen does not induce hyperactivity in zebrafish larvae. Reuter I, et al. J Neural Transm (Vienna), 2016 Aug. PMID 27116683
  3. Latrophilins: A Neuro-Centric View of an Evolutionary Conserved Adhesion G Protein-Coupled Receptor Subfamily. Moreno-Salinas AL, et al. Front Neurosci, 2019. PMID 31354411, Free PMC Article
  4. A simple and efficient method for CRISPR/Cas9-induced mutant screening. Hua Y, et al. J Genet Genomics, 2017 Apr 20. PMID 28416245
  5. An Ultraconserved Brain-Specific Enhancer Within ADGRL3 (LPHN3) Underpins Attention-Deficit/Hyperactivity Disorder Susceptibility. Martinez AF, et al. Biol Psychiatry, 2016 Dec 15. PMID 27692237, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study found that lphn3.1 morphants have an overall hyposensitivity to dopamine agonists and antagonists compared to control fish. These results are compatible with a model whereby dopaminergic neurotransmission is saturated in lphn3.1 morphants.
    Title: Pharmacological analysis of zebrafish lphn3.1 morphant larvae suggests that saturated dopaminergic signaling could underlie the ADHD-like locomotor hyperactivity.
  2. results implicate decreased Lphn3 activity in eliciting ADHD-like behavior, and demonstrate its correlated contribution to the development of the brain dopaminergic circuitry
    Title: The ADHD-susceptibility gene lphn3.1 modulates dopaminergic neuron formation and locomotor activity during zebrafish development.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to estrogen stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in system development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
latrophilin-3; adhesion G protein-coupled receptor L3
Names
latrophilin 3
latrophilin 3.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    22943546..23157716 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005170941.4 → XP_005170998.1  adhesion G protein-coupled receptor L3 isoform X2

    UniProtKB/TrEMBL
    A0A8M2BI50
    Conserved Domains (7) summary
    smart00284
    Location:160 → 415
    OLF; Olfactomedin-like domains
    smart00303
    Location:806 → 858
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:493 → 553
    HormR; Domain present in hormone receptors
    pfam00002
    Location:867 → 1102
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:66 → 146
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1123 → 1539
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:562 → 780
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  2. XM_684028.9 → XP_689120.5  adhesion G protein-coupled receptor L3 isoform X5

    UniProtKB/TrEMBL
    A0A2R8Q6E9, A0A8N7UUV2
    Related
    ENSDARP00000148668.1, ENSDART00000189344.1
    Conserved Domains (7) summary
    smart00284
    Location:160 → 415
    OLF; Olfactomedin-like domains
    smart00303
    Location:807 → 859
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:493 → 553
    HormR; Domain present in hormone receptors
    pfam00002
    Location:868 → 1103
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:66 → 146
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1124 → 1492
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:562 → 780
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  3. XM_021476346.1 → XP_021332021.1  adhesion G protein-coupled receptor L3 isoform X4

    UniProtKB/TrEMBL
    A0A8M9Q934
    Conserved Domains (9) summary
    smart00284
    Location:160 → 415
    OLF; Olfactomedin-like domains
    smart00303
    Location:807 → 859
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:493 → 553
    HormR; Domain present in hormone receptors
    pfam02140
    Location:66 → 146
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1124 → 1498
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:562 → 782
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:870 → 894
    7tm_GPCRs; TM helix 1 [structural motif]
    cl26464
    Location:424 → 539
    Atrophin-1; Atrophin-1 family
    cl28897
    Location:867 → 1124
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  4. XM_005170942.4 → XP_005170999.1  adhesion G protein-coupled receptor L3 isoform X3

    UniProtKB/TrEMBL
    A0A8M2BI94, F1Q579
    Related
    ENSDARP00000081231.6, ENSDART00000086797.6
    Conserved Domains (7) summary
    smart00284
    Location:160 → 415
    OLF; Olfactomedin-like domains
    smart00303
    Location:807 → 859
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:493 → 553
    HormR; Domain present in hormone receptors
    pfam00002
    Location:868 → 1103
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:66 → 146
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1124 → 1534
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:562 → 780
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  5. XM_005170940.4 → XP_005170997.1  adhesion G protein-coupled receptor L3 isoform X1

    UniProtKB/TrEMBL
    A0A2R8QM07, A0A8M2BIN7
    Related
    ENSDARP00000156478.1, ENSDART00000190858.1
    Conserved Domains (7) summary
    smart00284
    Location:160 → 415
    OLF; Olfactomedin-like domains
    smart00303
    Location:807 → 859
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:493 → 553
    HormR; Domain present in hormone receptors
    pfam00002
    Location:868 → 1103
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:66 → 146
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1124 → 1540
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:562 → 780
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
Nucleotide Protein
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