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Fmo2 flavin containing monooxygenase 2 [ Mus musculus (house mouse) ]

Gene ID: 55990, updated on 5-Mar-2024

Summary

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Official Symbol
Fmo2provided by MGI
Official Full Name
flavin containing monooxygenase 2provided by MGI
Primary source
MGI:MGI:1916776
See related
Ensembl:ENSMUSG00000040170 AllianceGenome:MGI:1916776
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310008D08Rik; 2310042I22Rik
Summary
Enables monooxygenase activity. Acts upstream of or within oxygen metabolic process. Predicted to be located in membrane. Is expressed in several structures, including alimentary system; limb; mesothelium; metanephros; and nose. Orthologous to human FMO2 (flavin containing dimethylaniline monoxygenase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 71.4), lung adult (RPKM 60.7) and 4 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 H2.1; 1 70.34 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (162701886..162726327, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (162874317..162898758, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm713 Neighboring gene flavin containing monooxygenase 1 Neighboring gene STARR-seq mESC enhancer starr_02846 Neighboring gene predicted gene, 32197 Neighboring gene flavin containing monooxygenase 6 Neighboring gene predicted gene, 32279 Neighboring gene flavin containing monooxygenase 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Sequencing, expression, and characterization of cDNA expressed flavin-containing monooxygenase 2 from mouse. Karoly ED, et al. J Biochem Mol Toxicol, 2001. PMID 11835629
  2. Brown adipose tissue dysfunction promotes heart failure via a trimethylamine N-oxide-dependent mechanism. Yoshida Y, et al. Sci Rep, 2022 Sep 1. PMID 36050466, Free PMC Article
  3. The phenotype of a flavin-containing monooyxgenase knockout mouse implicates the drug-metabolizing enzyme FMO1 as a novel regulator of energy balance. Veeravalli S, et al. Biochem Pharmacol, 2014 Jul 1. PMID 24792439
  4. The FMO2 gene of laboratory rats, as in most humans, encodes a truncated protein. Lattard V, et al. Biochem Biophys Res Commun, 2002 Mar 29. PMID 11906197
  5. Flavin-Containing Monooxygenase 1 Catalyzes the Production of Taurine from Hypotaurine. Veeravalli S, et al. Drug Metab Dispos, 2020 May. PMID 32156684

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Flavin containing monooxygenase 2 regulates renal tubular cell fibrosis and paracrine secretion via SMURF2 in AKI-CKD transformation.
    Title: Flavin containing monooxygenase 2 regulates renal tubular cell fibrosis and paracrine secretion via SMURF2 in AKI‑CKD transformation.
  2. Data indicate that in contrast to FMO2 and FMO4, FMO1 is highly expressed in metabolic tissues, including liver, kidney, white adipose tissue (WAT) and brown adipose tissue (BAT).
    Title: The phenotype of a flavin-containing monooyxgenase knockout mouse implicates the drug-metabolizing enzyme FMO1 as a novel regulator of energy balance.
  3. sequencing, expression, and characterization of cDNA
    Title: Sequencing, expression, and characterization of cDNA expressed flavin-containing monooxygenase 2 from mouse.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC28212

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N,N-dimethylaniline monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N,N-dimethylaniline monooxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables NADP binding IEA
Inferred from Electronic Annotation
more info
  
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in NADP metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in NADPH oxidation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within energy homeostasis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of fatty acid oxidation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in organic acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within oxygen metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in toxin metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in xenobiotic metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dimethylaniline monooxygenase [N-oxide-forming] 2
Names
FMO 2
dimethylaniline oxidase 2
pulmonary flavin-containing monooxygenase 2
NP_001347842.1
NP_001347843.1
NP_061369.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360913.1 → NP_001347842.1  dimethylaniline monooxygenase [N-oxide-forming] 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 all encode the same protein.
    Source sequence(s)
    AC117767, AF184981
    Consensus CDS
    CCDS15425.1
    UniProtKB/Swiss-Prot
    Q8K2I3, Q9QZF7
    Related
    ENSMUSP00000107135.2, ENSMUST00000111510.8
    Conserved Domains (1) summary
    cl26174
    Location:2 → 532
    K_oxygenase; L-lysine 6-monooxygenase (NADPH-requiring)

  2. NM_001360914.1 → NP_001347843.1  dimethylaniline monooxygenase [N-oxide-forming] 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same protein.
    Source sequence(s)
    AC117767, AF184981, AI876829
    Consensus CDS
    CCDS15425.1
    UniProtKB/Swiss-Prot
    Q8K2I3, Q9QZF7
    Conserved Domains (1) summary
    cl26174
    Location:2 → 532
    K_oxygenase; L-lysine 6-monooxygenase (NADPH-requiring)

  3. NM_018881.4 → NP_061369.2  dimethylaniline monooxygenase [N-oxide-forming] 2

    See identical proteins and their annotated locations for NP_061369.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same protein.
    Source sequence(s)
    AC117767
    Consensus CDS
    CCDS15425.1
    UniProtKB/Swiss-Prot
    Q8K2I3, Q9QZF7
    Related
    ENSMUSP00000044405.7, ENSMUST00000045902.13
    Conserved Domains (1) summary
    cl26174
    Location:2 → 532
    K_oxygenase; L-lysine 6-monooxygenase (NADPH-requiring)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    162701886..162726327 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K2I3.3 GenPept UniProtKB/Swiss-Prot:Q8K2I3

Gene LinkOut

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