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Ctps2 cytidine 5'-triphosphate synthase 2 [ Mus musculus (house mouse) ]

Gene ID: 55936, updated on 11-Apr-2024

Summary

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Official Symbol
Ctps2provided by MGI
Official Full Name
cytidine 5'-triphosphate synthase 2provided by MGI
Primary source
MGI:MGI:1933185
See related
Ensembl:ENSMUSG00000031360 AllianceGenome:MGI:1933185
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ctpsh; A830031M15Rik
Summary
Predicted to enable CTP synthase activity and identical protein binding activity. Predicted to be involved in CTP biosynthetic process and pyrimidine nucleobase biosynthetic process. Predicted to act upstream of or within glutamine metabolic process and pyrimidine nucleotide biosynthetic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human CTPS2 (CTP synthase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 5.8), cerebellum adult (RPKM 5.0) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Ctps2 in Genome Data Viewer
Location:
X F4; X 75.09 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (161684264..161817537)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (162901268..163034541)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11687 Neighboring gene synapse associated protein 1 Neighboring gene microRNA 3473a Neighboring gene predicted gene 15209 Neighboring gene Mki67 (FHA domain) interacting nucleolar phosphoprotein pseudogene Neighboring gene STARR-seq mESC enhancer starr_48220 Neighboring gene STARR-seq mESC enhancer starr_48221 Neighboring gene STARR-seq mESC enhancer starr_48222 Neighboring gene S100 calcium binding protein G Neighboring gene STARR-seq mESC enhancer starr_48223 Neighboring gene STARR-seq mESC enhancer starr_48224 Neighboring gene STARR-seq mESC enhancer starr_48225 Neighboring gene predicted gene, 22746 Neighboring gene STARR-seq mESC enhancer starr_48226 Neighboring gene STARR-seq mESC enhancer starr_48227 Neighboring gene STARR-seq mESC enhancer starr_48228 Neighboring gene predicted gene 15212

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CTPS and IMPDH form cytoophidia in developmental thymocytes. Peng M, et al. Exp Cell Res, 2021 Aug 1. PMID 34022203
  2. Phenotypic annotation of the mouse X chromosome. Cox BJ, et al. Genome Res, 2010 Aug. PMID 20548051, Free PMC Article
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (2) 
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables CTP synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in CTP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within glutamine metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pyrimidine nucleobase biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within pyrimidine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pyrimidine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoophidium IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
CTP synthase 2
Names
CTP synthetase 2
CTP synthetase homolog
UTP--ammonia ligase 2
cytidine triphosphate synthase II
NP_001162040.1
NP_001162041.1
NP_001162043.1
NP_001345327.1
NP_061207.1
XP_006528975.1
XP_006528976.1
XP_006528978.1
XP_030107269.1
XP_030107270.1
XP_036017926.1
XP_036017927.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168568.1 → NP_001162040.1  CTP synthase 2 isoform a

    See identical proteins and their annotated locations for NP_001162040.1

    Status: VALIDATED

    Source sequence(s)
    AK084595, AL671975, AW048867, BY288253
    Consensus CDS
    CCDS41202.1
    UniProtKB/Swiss-Prot
    P70303, Q3TPQ2, Q3TT59
    Related
    ENSMUSP00000033727.8, ENSMUST00000033727.14
    Conserved Domains (1) summary
    PLN02327
    Location:1 → 557
    PLN02327; CTP synthase

  2. NM_001168569.1 → NP_001162041.1  CTP synthase 2 isoform a

    See identical proteins and their annotated locations for NP_001162041.1

    Status: VALIDATED

    Source sequence(s)
    AK052854, AL671975, AW048867, BY314159
    Consensus CDS
    CCDS41202.1
    UniProtKB/Swiss-Prot
    P70303, Q3TPQ2, Q3TT59
    Related
    ENSMUSP00000107922.2, ENSMUST00000112303.8
    Conserved Domains (1) summary
    PLN02327
    Location:1 → 557
    PLN02327; CTP synthase

  3. NM_001168571.1 → NP_001162043.1  CTP synthase 2 isoform b

    See identical proteins and their annotated locations for NP_001162043.1

    Status: VALIDATED

    Source sequence(s)
    AK164206, AL671975, AW048867, BY098422, BY314159
    Consensus CDS
    CCDS53240.1
    UniProtKB/Swiss-Prot
    P70303
    Related
    ENSMUSP00000107921.2, ENSMUST00000112302.8
    Conserved Domains (3) summary
    cd01746
    Location:299 → 493
    GATase1_CTP_Synthase; Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase
    PLN02327
    Location:1 → 506
    PLN02327; CTP synthase
    pfam06418
    Location:2 → 272
    CTP_synth_N; CTP synthase N-terminus

  4. NM_001358398.1 → NP_001345327.1  CTP synthase 2 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL671975, AL807822, AW048867
    Conserved Domains (1) summary
    PLN02327
    Location:50 → 606
    PLN02327; CTP synthase

  5. NM_018737.5 → NP_061207.1  CTP synthase 2 isoform a

    See identical proteins and their annotated locations for NP_061207.1

    Status: VALIDATED

    Source sequence(s)
    AK150966, AL671975, AW048867, BY098422, BY314159
    Consensus CDS
    CCDS41202.1
    UniProtKB/Swiss-Prot
    P70303, Q3TPQ2, Q3TT59
    Related
    ENSMUSP00000107920.2, ENSMUST00000112301.8
    Conserved Domains (1) summary
    PLN02327
    Location:1 → 557
    PLN02327; CTP synthase

RNA

  1. NR_033143.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL671975, AL807822, AW048867

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    161684264..161817537
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006528912.3 → XP_006528975.1  CTP synthase 2 isoform X1

    See identical proteins and their annotated locations for XP_006528975.1

    UniProtKB/Swiss-Prot
    P70303, Q3TPQ2, Q3TT59
    Conserved Domains (1) summary
    PLN02327
    Location:1 → 557
    PLN02327; CTP synthase

  2. XM_006528913.3 → XP_006528976.1  CTP synthase 2 isoform X1

    See identical proteins and their annotated locations for XP_006528976.1

    UniProtKB/Swiss-Prot
    P70303, Q3TPQ2, Q3TT59
    Conserved Domains (1) summary
    PLN02327
    Location:1 → 557
    PLN02327; CTP synthase

  3. XM_030251409.2 → XP_030107269.1  CTP synthase 2 isoform X2

    Conserved Domains (1) summary
    PLN02327
    Location:4 → 432
    PLN02327; CTP synthase

  4. XM_030251410.2 → XP_030107270.1  CTP synthase 2 isoform X3

    Conserved Domains (1) summary
    PLN02327
    Location:1 → 401
    PLN02327; CTP synthase

  5. XM_036162034.1 → XP_036017927.1  CTP synthase 2 isoform X3

    Conserved Domains (1) summary
    PLN02327
    Location:1 → 401
    PLN02327; CTP synthase

  6. XM_006528915.2 → XP_006528978.1  CTP synthase 2 isoform X2

    See identical proteins and their annotated locations for XP_006528978.1

    Conserved Domains (1) summary
    PLN02327
    Location:4 → 432
    PLN02327; CTP synthase

  7. XM_036162033.1 → XP_036017926.1  CTP synthase 2 isoform X1

    UniProtKB/Swiss-Prot
    P70303, Q3TPQ2, Q3TT59
    Conserved Domains (1) summary
    PLN02327
    Location:1 → 557
    PLN02327; CTP synthase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70303.1 GenPept UniProtKB/Swiss-Prot:P70303

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