clcn3 chloride channel 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: clcn3provided by ZNC
Official Full Name: chloride channel 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-1699
See related: Ensembl:ENSDARG00000003269 AllianceGenome:ZFIN:ZDB-GENE-030131-1699
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fb78c02; wu:fb78c02
Summary: Predicted to enable solute:proton antiporter activity and voltage-gated chloride channel activity. Predicted to act upstream of or within chloride transport and transmembrane transport. Predicted to be located in early endosome membrane; late endosome membrane; and lysosomal membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus; early endosome; and synaptic vesicle. Predicted to be integral component of plasma membrane. Is expressed in several structures, including eye; female organism; heart; liver; and pleuroperitoneal region. Orthologous to human CLCN3 (chloride voltage-gated channel 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (7511869..7642050)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (7278501..7408672)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fk72e08.x1 (e-PCR)
- UniSTS:201476

fj05h11.y1 (e-PCR)
- UniSTS:198412

fb78c02.x1 (e-PCR)
- UniSTS:203437

fk70h07.x1 (e-PCR)
- UniSTS:201451

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables voltage-gated chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated chloride channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chloride transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in late endosome membrane	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: H(+)/Cl(-) exchange transporter 3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007118.7 Reference GRCz11 Primary Assembly

Range

7511869..7642050

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021477691.1 → XP_021333366.1 H(+)/Cl(-) exchange transporter 3 isoform X3

UniProtKB/TrEMBL

A0A8M9PPD0

Conserved Domains (2) summary

cd03684
Location:140 → 648

ClC_3_like; ClC-3-like chloride channel proteins. This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has ...

cd04591
Location:671 → 809

CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
XM_021477689.1 → XP_021333364.1 H(+)/Cl(-) exchange transporter 3 isoform X1

UniProtKB/TrEMBL

A0A140LGR0, A0A8M9Q887

Related

ENSDARP00000142439.1, ENSDART00000172848.2

Conserved Domains (2) summary

cd03684
Location:140 → 648

ClC_3_like; ClC-3-like chloride channel proteins. This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has ...

cd04591
Location:671 → 809

CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
XM_021477693.1 → XP_021333368.1 H(+)/Cl(-) exchange transporter 3 isoform X4

UniProtKB/TrEMBL

A0A8M9Q239

Conserved Domains (2) summary

cd03684
Location:140 → 648

ClC_3_like; ClC-3-like chloride channel proteins. This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has ...

cd04591
Location:671 → 809

CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
XM_021477692.1 → XP_021333367.1 H(+)/Cl(-) exchange transporter 3 isoform X3

UniProtKB/TrEMBL

A0A8M9PPD0

Conserved Domains (2) summary

cd03684
Location:140 → 648

ClC_3_like; ClC-3-like chloride channel proteins. This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has ...

cd04591
Location:671 → 809

CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
XM_021477690.1 → XP_021333365.1 H(+)/Cl(-) exchange transporter 3 isoform X2

UniProtKB/TrEMBL

A0A8M9QHF3, F1R7J9

Related

ENSDARP00000049310.7, ENSDART00000049311.7

Conserved Domains (2) summary

cd03684
Location:115 → 623

ClC_3_like; ClC-3-like chloride channel proteins. This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has ...

cd04591
Location:646 → 784

CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
XM_021477694.1 → XP_021333369.1 H(+)/Cl(-) exchange transporter 3 isoform X5

UniProtKB/TrEMBL

A0A8M9Q891

Related

ENSDARP00000142496.1, ENSDART00000173018.2

Conserved Domains (2) summary

cd03684
Location:115 → 623

ClC_3_like; ClC-3-like chloride channel proteins. This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has ...

cd04591
Location:646 → 784

CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...

Reference GRCz11 ALT_DRER_TU_1

Genomic

NW_018394672.1 Reference GRCz11 ALT_DRER_TU_1

Range

62642..173786

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005166349.4 → XP_005166406.1 H(+)/Cl(-) exchange transporter 3 isoform X3

See identical proteins and their annotated locations for XP_005166406.1

UniProtKB/TrEMBL

A0A8M9PPD0

Conserved Domains (2) summary

cd03684
Location:140 → 648

ClC_3_like; ClC-3-like chloride channel proteins. This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has ...

cd04591
Location:671 → 809

CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
XM_001923468.7 → XP_001923503.1 H(+)/Cl(-) exchange transporter 3 isoform X1

See identical proteins and their annotated locations for XP_001923503.1

UniProtKB/TrEMBL

A0A140LGR0, A0A8M9Q887

Conserved Domains (2) summary

cd03684
Location:140 → 648

ClC_3_like; ClC-3-like chloride channel proteins. This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has ...

cd04591
Location:671 → 809

CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
XM_005166348.4 → XP_005166405.1 H(+)/Cl(-) exchange transporter 3 isoform X4

UniProtKB/TrEMBL

A0A8M9Q239

Conserved Domains (2) summary

cd03684
Location:140 → 648

ClC_3_like; ClC-3-like chloride channel proteins. This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has ...

cd04591
Location:671 → 809

CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
XM_009302926.3 → XP_009301201.1 H(+)/Cl(-) exchange transporter 3 isoform X3

See identical proteins and their annotated locations for XP_009301201.1

UniProtKB/TrEMBL

A0A8M9PPD0

Conserved Domains (2) summary

cd03684
Location:140 → 648

ClC_3_like; ClC-3-like chloride channel proteins. This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has ...

cd04591
Location:671 → 809

CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
XM_005166345.4 → XP_005166402.1 H(+)/Cl(-) exchange transporter 3 isoform X1

See identical proteins and their annotated locations for XP_005166402.1

UniProtKB/TrEMBL

A0A140LGR0, A0A8M9Q887

Conserved Domains (2) summary

cd03684
Location:140 → 648

ClC_3_like; ClC-3-like chloride channel proteins. This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has ...

cd04591
Location:671 → 809

CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
XM_003198891.5 → XP_003198939.1 H(+)/Cl(-) exchange transporter 3 isoform X2

UniProtKB/TrEMBL

A0A8M9QHF3, F1R7J9

Conserved Domains (2) summary

cd03684
Location:115 → 623

ClC_3_like; ClC-3-like chloride channel proteins. This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has ...

cd04591
Location:646 → 784

CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
XM_005166350.4 → XP_005166407.1 H(+)/Cl(-) exchange transporter 3 isoform X5

UniProtKB/TrEMBL

A0A8M9Q891

Conserved Domains (2) summary

cd03684
Location:115 → 623

ClC_3_like; ClC-3-like chloride channel proteins. This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has ...

cd04591
Location:646 → 784

CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...