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fosl2 FOS like 2, AP-1 transcription factor subunit [ Danio rerio (zebrafish) ]

Gene ID: 558921, updated on 27-Mar-2024

Summary

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Official Symbol
fosl2provided by ZNC
Official Full Name
FOS like 2, AP-1 transcription factor subunitprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070209-164
See related
Ensembl:ENSDARG00000040623 AllianceGenome:ZFIN:ZDB-GENE-070209-164
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fra2; wu:fl03b09; wu:fl17h04; xx:fl17h04; zgc:158347
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within regulation of cardiac muscle cell myoblast differentiation. Predicted to be active in nucleus. Is expressed in head; presumptive bulbus arteriosus; presumptive cardiac ventricle heart tube; and trunk. Orthologous to human FOSL2 (FOS like 2, AP-1 transcription factor subunit). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See fosl2 in Genome Data Viewer
Location:
chromosome: 17
Exon count:
4
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (41302606..41318554)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (41313748..41329680)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene ribokinase Neighboring gene uncharacterized LOC101885155 Neighboring gene BRISC and BRCA1 A complex member 2 Neighboring gene molybdenum cofactor synthesis 1 Neighboring gene uncharacterized LOC108179794

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Paradoxical Changes Underscore Epigenetic Reprogramming During Adult Zebrafish Extraocular Muscle Regeneration. Tingle CF, et al. Invest Ophthalmol Vis Sci, 2019 Dec 2. PMID 31794598, Free PMC Article
  2. The AP-1 transcription factor component Fosl2 potentiates the rate of myocardial differentiation from the zebrafish second heart field. Jahangiri L, et al. Development, 2016 Jan 1. PMID 26732840, Free PMC Article
  3. AP-1 Contributes to Chromatin Accessibility to Promote Sarcomere Disassembly and Cardiomyocyte Protrusion During Zebrafish Heart Regeneration. Beisaw A, et al. Circ Res, 2020 Jun 5. PMID 32312172, Free PMC Article
  4. Hyperactivity, Memory Defects, and Craniofacial Abnormalities in Zebrafish fmr1 Mutant Larvae. Hu J, et al. Behav Genet, 2020 May. PMID 32048109
  5. Epoxyeicosatrienoic acids enhance embryonic haematopoiesis and adult marrow engraftment. Li P, et al. Nature, 2015 Jul 23. PMID 26201599, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phylogenetic and Expression Analysis of Fos Transcription Factors in Zebrafish.
    Title: Phylogenetic and Expression Analysis of Fos Transcription Factors in Zebrafish.
  2. Fos-like antigen 2 (Fosl2), potentiates the rate of myocardial accretion from the zebrafish second heart field.
    Title: The AP-1 transcription factor component Fosl2 potentiates the rate of myocardial differentiation from the zebrafish second heart field.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC158347

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of cardiac muscle cell myoblast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
fos-related antigen 2
Names
fos-like antigen 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082998.2 → NP_001076467.1  fos-related antigen 2 isoform 1

    See identical proteins and their annotated locations for NP_001076467.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    CABZ01079144, CABZ01079145, CABZ01079146
    UniProtKB/TrEMBL
    A0A8M1NDK2, A2RUX8
    Related
    ENSDARP00000059479.4, ENSDART00000059480.5
    Conserved Domains (1) summary
    cd14721
    Location:135 → 188
    bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain

  2. NM_001362607.1 → NP_001349536.1  fos-related antigen 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    CABZ01079144, CABZ01079145, CABZ01079146
    UniProtKB/TrEMBL
    A0A8M2BKU3
    Conserved Domains (1) summary
    cd14721
    Location:96 → 149
    bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    41302606..41318554
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005173580.4 → XP_005173637.1  fos-related antigen 2 isoform X1

    UniProtKB/TrEMBL
    A2RUX8
    Conserved Domains (1) summary
    cd14721
    Location:135 → 188
    bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain

  2. XM_005173581.4 → XP_005173638.1  fos-related antigen 2 isoform X2

    Conserved Domains (1) summary
    cd14721
    Location:96 → 149
    bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain
Nucleotide Protein Strain
Heading Accession and Version

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