cyp27c1 cytochrome P450, family 27, subfamily C, polypeptide 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cyp27c1provided by ZNC
Official Full Name: cytochrome P450, family 27, subfamily C, polypeptide 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-080204-68
See related: Ensembl:ENSDARG00000092660 AllianceGenome:ZFIN:ZDB-GENE-080204-68
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sb:eu635; zgc:172278
Summary: Predicted to enable oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen and retinoid binding activity. Predicted to be active in mitochondrion. Is expressed in several structures, including immature eye; margin; neural tube; retina; and yolk syncytial layer. Orthologous to human CYP27C1 (cytochrome P450 family 27 subfamily C member 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 6

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (9568149..9581946, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (9332610..9346407, complement)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The expression of a single enzyme (a cytochrome P450 family member, Cyp27c1) mediates dynamic spectral tuning of the entire visual system by controlling the balance of vitamin A1 and A2 in the eye in zebrafish.
Title: Cyp27c1 Red-Shifts the Spectral Sensitivity of Photoreceptors by Converting Vitamin A1 into A2.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables all-trans retinal 3,4-desaturase activity	IBA Inferred from Biological aspect of Ancestor more info
enables all-trans retinoic acid 3,4-desaturase activity	IBA Inferred from Biological aspect of Ancestor more info
enables all-trans retinol 3,4-desaturase activity	IBA Inferred from Biological aspect of Ancestor more info
enables all-trans-retinol binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info
enables retinoic acid binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cytochrome P450 27C1

Names: all-trans retinol 3,4-desaturase

NP_001106808.2

EC 1.14.19.53

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113337.3 → NP_001106808.2 cytochrome P450 27C1

Status: VALIDATED

Source sequence(s)

BX927387

UniProtKB/Swiss-Prot

A8WGA0, F1QMI2

Related

ENSDARP00000118349.1, ENSDART00000144335.2

Conserved Domains (1) summary

pfam00067
Location:74 → 517

p450; Cytochrome P450