fam20b FAM20B glycosaminoglycan xylosylkinase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fam20bprovided by ZNC
Official Full Name: FAM20B glycosaminoglycan xylosylkinaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040724-125
See related: Ensembl:ENSDARG00000008573 AllianceGenome:ZFIN:ZDB-GENE-040724-125
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:136944; si:ch211-195o19.3
Summary: Predicted to enable phosphotransferase activity, alcohol group as acceptor. Acts upstream of or within embryonic cranial skeleton morphogenesis and proteoglycan biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be integral component of membrane. Predicted to colocalize with Golgi apparatus. Is expressed in brain; ceratohyal cartilage; ethmoid cartilage; palatoquadrate cartilage; and pectoral fin cartilage. Orthologous to human FAM20B (FAM20B glycosaminoglycan xylosylkinase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (15857041..15922483, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (15957458..16022903, complement)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

in vivo analyses reveal that fam20b and xylt1 function in cartilage matrix production and ultimately regulate the timing of skeletal development
Title: Mutations in fam20b and xylt1 reveal that cartilage matrix controls timing of endochondral ossification by inhibiting chondrocyte maturation.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables phosphotransferase activity, alcohol group as acceptor	IBA Inferred from Biological aspect of Ancestor more info
enables phosphotransferase activity, alcohol group as acceptor	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within embryonic cranial skeleton morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
NOT involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteoglycan biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteoglycan biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
colocalizes_with Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glycosaminoglycan xylosylkinase

Names: FAM20B, glycosaminoglycan xylosylkinas; family with sequence similarity 20, member B; unm b1127; unm_b1127

NP_001038283.1

EC 2.7.1.-

XP_005160477.1

EC 2.7.1.-

XP_009292888.1

EC 2.7.1.-

XP_009292889.1

EC 2.7.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.