inaa internexin neuronal intermediate filament protein, alpha a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: inaaprovided by ZNC
Official Full Name: internexin neuronal intermediate filament protein, alpha aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-060531-65
See related: Ensembl:ENSDARG00000011862 AllianceGenome:ZFIN:ZDB-GENE-060531-65
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:ch211-67n3.6
Summary: Predicted to act upstream of or within nervous system development. Located in intermediate filament. Is expressed in nervous system and optic cup. Orthologous to human INA (internexin neuronal intermediate filament protein alpha). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 13

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (28675686..28681036)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (28545236..28550586)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study provided a detailed characterization of inaa in the zebrafish; reports evidence that supports zebrafish inaa as a homologous protein of mammalian alpha-internexin and that, physiologically, inaa exhibited the properties of mammalian alpha-internexin. The distribution of inaa was dynamic and widespread through the zebrafish retinal development. Inaa was distinctively expressed in the cone photoreceptors of zebrafish.
Title: Developmental pattern of the neuronal intermediate filament inaa in the zebrafish retina.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables structural constituent of postsynaptic intermediate filament cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in intermediate filament organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in intermediate filament	IBA Inferred from Biological aspect of Ancestor more info
located_in intermediate filament	IDA Inferred from Direct Assay more info	PubMed
located_in intermediate filament	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic intermediate filament cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: internexin neuronal intermediate filament protein, alpha a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001144784.1 → NP_001138256.1 internexin neuronal intermediate filament protein, alpha a

Status: PROVISIONAL

Source sequence(s)

AL928951

UniProtKB/TrEMBL

A0A8N1TT67, A2ATX5

Related

ENSDARP00000012437.7, ENSDART00000027213.8

Conserved Domains (2) summary

pfam00038
Location:93 → 403

Filament; Intermediate filament protein

pfam04732
Location:8 → 92

Filament_head; Intermediate filament head (DNA binding) region