dpysl5b dihydropyrimidinase like 5b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dpysl5bprovided by ZNC
Official Full Name: dihydropyrimidinase like 5bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050720-4
See related: Ensembl:ENSDARG00000059311 AllianceGenome:ZFIN:ZDB-GENE-050720-4
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: CRMP-5b; crmp5.2; si:ch211-152c2.6
Summary: Predicted to enable hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds and microtubule binding activity. Predicted to act upstream of or within axon guidance. Predicted to be located in cytoplasm. Is expressed in central nervous system and trigeminal ganglion. Human ortholog(s) of this gene implicated in Ritscher-Schinzel syndrome. Orthologous to human DPYSL5 (dihydropyrimidinase like 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (798700..815852, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (785252..802404, complement)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
NOT enables dihydropyrimidinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
NOT involved_in pyrimidine nucleobase catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: dihydropyrimidinase-related protein 5b

Names: collapsin response mediator protein 5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001020515.1 → NP_001018351.1 dihydropyrimidinase-related protein 5b

See identical proteins and their annotated locations for NP_001018351.1

Status: PROVISIONAL

Source sequence(s)

AY987370

UniProtKB/TrEMBL

Q52PJ8

Related

ENSDARP00000067454.6, ENSDART00000067455.8

Conserved Domains (2) summary

PRK09060
Location:12 → 451

PRK09060; dihydroorotase; Validated

cd01314
Location:11 → 460

D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...