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lnx2a ligand of numb-protein X 2a [ Danio rerio (zebrafish) ]

Gene ID: 553331, updated on 27-Mar-2024

Summary

Official Symbol
lnx2aprovided by ZNC
Official Full Name
ligand of numb-protein X 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060228-2
See related
Ensembl:ENSDARG00000029177 AllianceGenome:ZFIN:ZDB-GENE-060228-2
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
lnx2
Summary
Enables ubiquitin protein ligase activity. Acts upstream of or within exocrine pancreas development and protein phosphopantetheinylation. Is expressed in central nervous system; endoderm; and pancreatic system. Orthologous to human LNX2 (ligand of numb-protein X 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See lnx2a in Genome Data Viewer
Location:
chromosome: 24
Exon count:
14
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (21646264..21674999, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (21501140..21529822, complement)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L21 Neighboring gene general transcription factor IIIA, b Neighboring gene si:ch211-140b10.6 Neighboring gene pancreatic and duodenal homeobox 1

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General protein information

Preferred Names
ligand of Numb protein X 2; ligand of Numb protein X 2a
Names
ligand of numb-protein X 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113225.2NP_001106696.2  ligand of Numb protein X 2a

    Status: VALIDATED

    Source sequence(s)
    BG305543, BX571696, DT867995, EB950577, EB957408, EH583415, FJ156085
    UniProtKB/TrEMBL
    A0A8M1NFK9, B6DRF5, F1R5N4
    Related
    ENSDARP00000046210.5, ENSDART00000046211.8
    Conserved Domains (3) summary
    smart00228
    Location:267353
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:646730
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam13639
    Location:4987
    zf-RING_2; Ring finger domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    21646264..21674999 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021470169.1XP_021325844.1  ligand of Numb protein X 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M9PLS6, B6DRF5
    Conserved Domains (1) summary
    cd00992
    Location:537621
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  2. XM_021470170.1XP_021325845.1  ligand of Numb protein X 2 isoform X2

    UniProtKB/TrEMBL
    A0A8M9PXH3
    Conserved Domains (1) summary
    cd00992
    Location:496580
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  3. XM_021470171.1XP_021325846.1  ligand of Numb protein X 2 isoform X3

    UniProtKB/TrEMBL
    A0A8M9PU28
    Conserved Domains (5) summary
    smart00228
    Location:267353
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:375455
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd16780
    Location:4488
    mRING-HC-C3HC3D_LNX2; Modified RING finger, HC subclass (C3HC3D-type), found in ligand of numb protein X 2 (LNX2)
    cl00117
    Location:515565
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cl26688
    Location:44201
    DWNN; DWNN domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395171.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    316958..344056 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)