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abcc8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 [ Danio rerio (zebrafish) ]

Gene ID: 553281, updated on 11-Apr-2024

Summary

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Official Symbol
abcc8provided by ZNC
Official Full Name
ATP-binding cassette, sub-family C (CFTR/MRP), member 8provided by ZNC
Primary source
ZFIN:ZDB-GENE-050517-22
See related
Ensembl:ENSDARG00000051879 AllianceGenome:ZFIN:ZDB-GENE-050517-22
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sur1
Summary
Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to act upstream of or within potassium ion transport. Predicted to be integral component of membrane. Predicted to be active in membrane. Is expressed in diencephalon; forebrain; hindbrain; and midbrain. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 1; glucose metabolism disease (multiple); hypertension; and leucine-sensitive hypoglycemia of infancy. Orthologous to human ABCC8 (ATP binding cassette subfamily C member 8). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 25
Exon count:
40
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (22720112..22849278)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (22622598..22751730)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene immunoglobulin superfamily containing leucine-rich repeat 2 Neighboring gene Usher syndrome 1C Neighboring gene potassium inwardly rectifying channel subfamily J member 11 Neighboring gene MOB kinase activator 2a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Expression and function of ATP-dependent potassium channels in zebrafish islet β-cells. Emfinger CH, et al. R Soc Open Sci, 2017 Feb. PMID 28386438, Free PMC Article
  2. Identification and characterization of a novel member of the ATP-sensitive K+ channel subunit family, Kir6.3, in zebrafish. Zhang C, et al. Physiol Genomics, 2006 Feb 14. PMID 16317080
  3. Control of metazoan heme homeostasis by a conserved multidrug resistance protein. Korolnek T, et al. Cell Metab, 2014 Jun 3. PMID 24836561, Free PMC Article
  4. The developmental effects of pentachlorophenol on zebrafish embryos during segmentation: A systematic view. Xu T, et al. Sci Rep, 2016 May 16. PMID 27181905, Free PMC Article
  5. Modelling pancreatic β-cell inflammation in zebrafish identifies the natural product wedelolactone for human islet protection. Delgadillo-Silva LF, et al. Dis Model Mech, 2019 Jan 23. PMID 30679186, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables sulfonylurea receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ATP-binding cassette sub-family C member 8
Names
sulfonylurea receptor subunit 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172647.2 → NP_001166118.2  ATP-binding cassette sub-family C member 8

    Status: VALIDATED

    Source sequence(s)
    BC163553, EB910253, EE213334
    UniProtKB/TrEMBL
    A0A8M1NTE0
    Related
    ENSDARP00000124481.1, ENSDART00000149455.3
    Conserved Domains (4) summary
    TIGR00957
    Location:26 → 1578
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    pfam00664
    Location:1025 → 1294
    ABC_membrane; ABC transporter transmembrane region
    cl00549
    Location:375 → 590
    ABC_membrane; ABC transporter transmembrane region
    cl21455
    Location:1342 → 1581
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    22720112..22849278
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021470491.1 → XP_021326166.1  ATP-binding cassette sub-family C member 8 isoform X3

    UniProtKB/TrEMBL
    A0A8M9PUX9
    Conserved Domains (1) summary
    cl26602
    Location:39 → 750
    SunT; ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]

  2. XM_005170687.4 → XP_005170744.1  ATP-binding cassette sub-family C member 8 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BI16, F1QMZ9
    Related
    ENSDARP00000082855.4, ENSDART00000088422.6
    Conserved Domains (4) summary
    TIGR00957
    Location:39 → 1591
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    pfam00664
    Location:1038 → 1307
    ABC_membrane; ABC transporter transmembrane region
    cl00549
    Location:388 → 603
    ABC_membrane; ABC transporter transmembrane region
    cl21455
    Location:1355 → 1594
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. XM_009298033.3 → XP_009296308.1  ATP-binding cassette sub-family C member 8 isoform X2

    UniProtKB/TrEMBL
    A0A8M3AP51
    Conserved Domains (4) summary
    TIGR01271
    Location:176 → 1526
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
    pfam00664
    Location:978 → 1247
    ABC_membrane; ABC transporter transmembrane region
    cl00549
    Location:328 → 543
    ABC_membrane; ABC transporter transmembrane region
    cl21455
    Location:1295 → 1534
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395204.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    23889..144547
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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