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PPP2R5C protein phosphatase 2 regulatory subunit B'gamma [ Homo sapiens (human) ]

Gene ID: 5527, updated on 3-Apr-2024

Summary

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Official Symbol
PPP2R5Cprovided by HGNC
Official Full Name
protein phosphatase 2 regulatory subunit B'gammaprovided by HGNC
Primary source
HGNC:HGNC:9311
See related
Ensembl:ENSG00000078304 MIM:601645; AllianceGenome:HGNC:9311
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B56G; PR61G; B56gamma
Summary
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lymph node (RPKM 21.8), testis (RPKM 19.2) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
14q32.31
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (101760573..101927992)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (95996275..96163606)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (102226910..102394329)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2320 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:102155672-102155835 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6093 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6094 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6095 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102174026-102174796 Neighboring gene ribosomal protein L26 pseudogene 4 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:102184781-102184986 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:102188573-102189513 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr14:102197209-102198408 Neighboring gene long intergenic non-protein coding RNA 239 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6096 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6097 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6098 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6099 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6102 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6101 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6100 Neighboring gene uncharacterized LOC107984658 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6103 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9045 Neighboring gene uncharacterized LOC124903388 Neighboring gene Sharpr-MPRA regulatory region 9024 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:102276373-102276955 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9048 Neighboring gene RNA, U6 small nuclear 790, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9049 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9050 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102299052-102299552 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9051 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9052 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9053 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9054 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9055 Neighboring gene nucleophosmin 1 pseudogene 20 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9056 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6104 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9057 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr14:102383507-102384162 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102394426-102394926 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102394927-102395427 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr14:102411293-102411954 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr14:102411955-102412614 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:102413937-102414598 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9059 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:102427622-102427798 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9061 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:102431258-102431867 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:102430647-102431257 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102436952-102437452 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9062 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9063 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9064 Neighboring gene dynein cytoplasmic 1 heavy chain 1 Neighboring gene NANOG hESC enhancer GRCh37_chr14:102474230-102474777 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:102493659-102494858 Neighboring gene uncharacterized LOC107984661 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102515797-102516781 Neighboring gene Sharpr-MPRA regulatory region 9666 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:102522673-102523378 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:102523379-102524082 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102530418-102531305 Neighboring gene RNA, 7SL, cytoplasmic 472, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Cryo-EM structure of the deltaretroviral intasome in complex with the PP2A regulatory subunit B56γ. Barski MS, et al. Nat Commun, 2020 Oct 7. PMID 33028863, Free PMC Article
  2. Structural basis of host protein hijacking in human T-cell leukemia virus integration. Bhatt V, et al. Nat Commun, 2020 Jun 19. PMID 32561747, Free PMC Article
  3. A dynamic charge-charge interaction modulates PP2A:B56 substrate recruitment. Wang X, et al. Elife, 2020 Mar 20. PMID 32195664, Free PMC Article
  4. Activation of ERK/IER3/PP2A-B56γ-positive feedback loop in lung adenocarcinoma by allelic deletion of B56γ gene. Ito T, et al. Oncol Rep, 2016 May. PMID 26986830
  5. PPP2R5C Couples Hepatic Glucose and Lipid Homeostasis. Cheng YS, et al. PLoS Genet, 2015 Oct. PMID 26440364, Free PMC Article

See all (114) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Combined detection of SDC2/ADHFE1/PPP2R5C methylation in stool DNA for colorectal cancer screening.
    Title: Combined detection of SDC2/ADHFE1/PPP2R5C methylation in stool DNA for colorectal cancer screening.
  2. A functional interaction between liprin-alpha1 and B56gamma regulatory subunit of protein phosphatase 2A supports tumor cell motility.
    Title: A functional interaction between liprin-α1 and B56γ regulatory subunit of protein phosphatase 2A supports tumor cell motility.
  3. [The Relationship between PPP2R5C and Molt-4 Cell Viability, HSP90-GR Signal in Childhood Acute T Lymphocytic Leukemia].
    Title: [The Relationship between PPP2R5C and Molt-4 Cell Viability, HSP90-GR Signal in Childhood Acute T Lymphocytic Leukemia].
  4. A dynamic charge-charge interaction modulates PP2A:B56 substrate recruitment.
    Title: A dynamic charge-charge interaction modulates PP2A:B56 substrate recruitment.
  5. Kelch-like protein 42 is a profibrotic ubiquitin E3 ligase involved in systemic sclerosis.
    Title: Kelch-like protein 42 is a profibrotic ubiquitin E3 ligase involved in systemic sclerosis.
  6. Cryo-EM structure of the deltaretroviral intasome in complex with the PP2A regulatory subunit B56gamma.
    Title: Cryo-EM structure of the deltaretroviral intasome in complex with the PP2A regulatory subunit B56γ.
  7. Structural basis of host protein hijacking in human T-cell leukemia virus integration.
    Title: Structural basis of host protein hijacking in human T-cell leukemia virus integration.
  8. PPP2R5C deletion or EGFR mutation that could be responsible for IER3/pERK overexpression was found in at least 8 cases (67% or more) of lung adenocarcinoma.
    Title: Activation of ERK/IER3/PP2A-B56γ-positive feedback loop in lung adenocarcinoma by allelic deletion of B56γ gene.
  9. Mutations in the PP2A regulatory subunit B family genes PPP2R5B, PPP2R5C and PPP2R5D cause human overgrowth
    Title: Mutations in the PP2A regulatory subunit B family genes PPP2R5B, PPP2R5C and PPP2R5D cause human overgrowth.
  10. our data suggest that hepatic PPP2R5C represents an important factor in the functional wiring of energy metabolism and the maintenance of a metabolically healthy state.
    Title: PPP2R5C Couples Hepatic Glucose and Lipid Homeostasis.
Submit: New GeneRIF Correction See all GeneRIFs (27)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide scan for common alleles affecting risk for autism.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the total levels of PP2A protein and downregulates the inactive form of phosphorylated PP2A, which leads to inhibit hTERT activity directly or indirectly in CD4+ T cells PubMed
tat Protein phosphatase-2A (PP2A) and protein phosphatase-1 (PP1) regulate HIV-1 Tat-activated transcription through dephosphorylation of CDK9 PubMed
tat An increase in the amount of PP2A core enzyme with a concomitant decrease in the amount of PP2A holoenzyme inhibits HIV-1 Tat-stimulated transcription from the HIV-1 LTR promoter, indicating a role for PP2A in the modulation of HIV-1 gene expression PubMed
Vpr vpr Amino-acid peptide sequence (residues 77-92) of HIV-1 Vpr binds to PP2A1. The sequence from HIV-1 89.6 strain is a cell penetrating and death domain PubMed
vpr HIV-1 Vpr was found to upregulate PP2A in fission yeast PubMed
vpr HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed
nucleocapsid gag HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC23064

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase regulator activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
  
located_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein phosphatase type 2A complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein phosphatase type 2A complex NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
Names
B' alpha regulatory subunit
protein phosphatase 2 regulatory subunit B', gamma
renal carcinoma antigen NY-REN-29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047069.1 RefSeqGene

    Range
    6137..172405
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001161725.2 → NP_001155197.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (e) has a distinct N-terminus and is longer than isoform a.
    Source sequence(s)
    AA487513, AI282996, AI692258, AK131391, AK302470, AL137779
    Consensus CDS
    CCDS53912.1
    UniProtKB/TrEMBL
    Q7L7W2
    Related
    ENSP00000412324.2, ENST00000422945.6
    Conserved Domains (2) summary
    PLN00122
    Location:373 → 473
    PLN00122; serine/threonine protein phosphatase 2A; Provisional
    pfam01603
    Location:65 → 468
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  2. NM_001161726.2 → NP_001155198.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform f

    See identical proteins and their annotated locations for NP_001155198.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. This variant also lacks an in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (f) has a distinct N-terminus and is longer than isoform a.
    Source sequence(s)
    AA487513, AI282996, AI692258, AK131391, AL137779
    Consensus CDS
    CCDS53911.1
    UniProtKB/TrEMBL
    Q96L52
    Related
    ENSP00000329009.5, ENST00000328724.9
    Conserved Domains (1) summary
    pfam01603
    Location:89 → 492
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  3. NM_001352912.1 → NP_001339841.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform b

    Status: REVIEWED

    Source sequence(s)
    AL118558, AL137779
    Consensus CDS
    CCDS9965.1
    UniProtKB/TrEMBL
    Q96L52
    Conserved Domains (1) summary
    pfam01603
    Location:32 → 437
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  4. NM_001352913.2 → NP_001339842.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform g

    Status: REVIEWED

    Source sequence(s)
    AL118558, AL137779
    Consensus CDS
    CCDS91934.1
    UniProtKB/TrEMBL
    A0A8Q3WKR3, Q7L7W2
    Related
    ENSP00000511581.1, ENST00000694906.1
    Conserved Domains (1) summary
    pfam01603
    Location:89 → 492
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  5. NM_001352914.2 → NP_001339843.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform h

    Status: REVIEWED

    Source sequence(s)
    AL118558, AL137779
    UniProtKB/TrEMBL
    Q96L52
    Conserved Domains (1) summary
    pfam01603
    Location:92 → 497
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  6. NM_001352915.2 → NP_001339844.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform j

    Status: REVIEWED

    Source sequence(s)
    AL118558, AL137779
    UniProtKB/TrEMBL
    Q7L7W2
    Conserved Domains (1) summary
    pfam01603
    Location:1 → 362
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  7. NM_001352916.2 → NP_001339845.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform i

    Status: REVIEWED

    Source sequence(s)
    AL118558, AL137779
    UniProtKB/TrEMBL
    Q96L52
    Conserved Domains (1) summary
    pfam01603
    Location:1 → 362
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  8. NM_002719.4 → NP_002710.2  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform a

    See identical proteins and their annotated locations for NP_002710.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform (a), also known as B' alpha 1 and gamma 3.
    Source sequence(s)
    AA487513, AI282996, AK131391, DA853338, U37352
    Consensus CDS
    CCDS9964.1
    UniProtKB/Swiss-Prot
    B4DYJ8, B5BUA5, F5GWP3, Q13362, Q14391, Q15060, Q15174, Q6ZN33
    UniProtKB/TrEMBL
    Q7L7W2
    Related
    ENSP00000333905.4, ENST00000334743.9
    Conserved Domains (2) summary
    PLN00122
    Location:342 → 442
    PLN00122; serine/threonine protein phosphatase 2A; Provisional
    pfam01603
    Location:34 → 437
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  9. NM_178586.3 → NP_848701.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform b

    See identical proteins and their annotated locations for NP_848701.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (b), also known as gamma 2.
    Source sequence(s)
    AA487513, AI282996, AK131391, D26445, DA853338
    Consensus CDS
    CCDS9965.1
    UniProtKB/TrEMBL
    Q96L52
    Related
    ENSP00000262239.5, ENST00000350249.7
    Conserved Domains (1) summary
    pfam01603
    Location:32 → 437
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  10. NM_178587.3 → NP_848702.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform c

    See identical proteins and their annotated locations for NP_848702.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and the 3' coding region, compared to variant 1. It encodes an isoform (c), also known as gamma 1, that is shorter and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AA716736, DA853338, L42375
    Consensus CDS
    CCDS45163.1
    UniProtKB/TrEMBL
    Q96L51
    Related
    ENSP00000408389.3, ENST00000445439.7
    Conserved Domains (1) summary
    pfam01603
    Location:34 → 437
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    101760573..101927992
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005267819.2 → XP_005267876.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1

    See identical proteins and their annotated locations for XP_005267876.1

    UniProtKB/TrEMBL
    Q7L7W2
    Conserved Domains (2) summary
    PLN00122
    Location:402 → 502
    PLN00122; serine/threonine protein phosphatase 2A; Provisional
    pfam01603
    Location:94 → 497
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  2. XM_005267824.2 → XP_005267881.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X3

    UniProtKB/TrEMBL
    Q96L52
    Conserved Domains (2) summary
    PLN00122
    Location:402 → 486
    PLN00122; serine/threonine protein phosphatase 2A; Provisional
    pfam01603
    Location:94 → 481
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  3. XM_005267827.2 → XP_005267884.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X11

    See identical proteins and their annotated locations for XP_005267884.1

    UniProtKB/TrEMBL
    Q7L7W2
    Conserved Domains (1) summary
    pfam01603
    Location:1 → 362
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  4. XM_047431541.1 → XP_047287497.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X11

  5. XM_047431540.1 → XP_047287496.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X12

  6. XM_047431530.1 → XP_047287486.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X2

  7. XM_047431533.1 → XP_047287489.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X7

  8. XM_047431534.1 → XP_047287490.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X8

  9. XM_047431537.1 → XP_047287493.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X11

  10. XM_011536920.2 → XP_011535222.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X11

    See identical proteins and their annotated locations for XP_011535222.1

    UniProtKB/TrEMBL
    Q7L7W2
    Conserved Domains (1) summary
    pfam01603
    Location:1 → 362
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  11. XM_017021423.3 → XP_016876912.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X9

    UniProtKB/TrEMBL
    Q96L52

  12. XM_047431539.1 → XP_047287495.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X11

  13. XM_047431532.1 → XP_047287488.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X4

  14. XM_047431536.1 → XP_047287492.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X11

  15. XM_047431538.1 → XP_047287494.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X11

  16. XM_005267826.2 → XP_005267883.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X6

    UniProtKB/TrEMBL
    Q7L7W2
    Conserved Domains (2) summary
    PLN00122
    Location:318 → 418
    PLN00122; serine/threonine protein phosphatase 2A; Provisional
    pfam01603
    Location:10 → 413
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  17. XM_047431531.1 → XP_047287487.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X4

  18. XM_011536918.2 → XP_011535220.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X5

    See identical proteins and their annotated locations for XP_011535220.1

    UniProtKB/TrEMBL
    Q7L7W2
    Conserved Domains (2) summary
    PLN00122
    Location:326 → 426
    PLN00122; serine/threonine protein phosphatase 2A; Provisional
    pfam01603
    Location:18 → 421
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  19. XM_047431535.1 → XP_047287491.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X10

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    95996275..96163606
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054376317.1 → XP_054232292.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X11

  2. XM_054376306.1 → XP_054232281.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1

  3. XM_054376308.1 → XP_054232283.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X3

  4. XM_054376316.1 → XP_054232291.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X12

  5. XM_054376307.1 → XP_054232282.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X2

  6. XM_054376311.1 → XP_054232286.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X7

  7. XM_054376312.1 → XP_054232287.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X8

  8. XM_054376315.1 → XP_054232290.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X11

  9. XM_054376313.1 → XP_054232288.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X9

  10. XM_054376310.1 → XP_054232285.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X6

  11. XM_054376309.1 → XP_054232284.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X5

  12. XM_054376314.1 → XP_054232289.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X10

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_178588.1: Suppressed sequence

    Description
    NM_178588.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q13362.3 GenPept UniProtKB/Swiss-Prot:Q13362

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