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DEF8 differentially expressed in FDCP 8 homolog [ Homo sapiens (human) ]

Gene ID: 54849, updated on 5-Mar-2024

Summary

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Official Symbol
DEF8provided by HGNC
Official Full Name
differentially expressed in FDCP 8 homologprovided by HGNC
Primary source
HGNC:HGNC:25969
See related
Ensembl:ENSG00000140995 AllianceGenome:HGNC:25969
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable metal ion binding activity. Predicted to be involved in lysosome localization; positive regulation of bone resorption; and positive regulation of ruffle assembly. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lymph node (RPKM 14.4), appendix (RPKM 9.2) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
16q24.3
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (89948755..89968060)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (96034997..96054302)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (90015163..90034468)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene keratin-associated protein 5-1-like Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr16:89984925-89985808 and GRCh37_chr16:89985809-89986692 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89986693-89987576 Neighboring gene Sharpr-MPRA regulatory region 7867 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7932 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89991680-89992580 Neighboring gene melanocortin 1 receptor Neighboring gene tubulin beta 3 class III Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11428 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11429 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7934 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11430 Neighboring gene small nucleolar RNA, H/ACA box 119 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11431 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:90039036-90040019 Neighboring gene CENPB DNA-binding domain containing 1, pseudogene Neighboring gene AFG3 like matrix AAA peptidase subunit 1, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr16:90054784-90054958 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:90059900-90060881 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:90061681-90062880 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_46884 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_46891 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:90066749-90066899

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Involvement of autophagic protein DEF8 in Lewy bodies. Tanaka MT, et al. Biochem Biophys Res Commun, 2022 Oct 1. PMID 35921708
  2. DEF8 and Autophagy-Associated Genes Are Altered in Mild Cognitive Impairment, Probable Alzheimer's Disease Patients, and a Transgenic Model of the Disease. Leyton E, et al. J Alzheimers Dis, 2021. PMID 33612542
  3. PLEKHM1/DEF8/RAB7 complex regulates lysosome positioning and bone homeostasis. Fujiwara T, et al. JCI Insight, 2016 Oct 20. PMID 27777970, Free PMC Article
  4. DCAF8, a novel MuRF1 interaction partner, promotes muscle atrophy. Nowak M, et al. J Cell Sci, 2019 Sep 6. PMID 31391242
  5. C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy. Yan BR, et al. Autophagy, 2022 Apr. PMID 34432599, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Involvement of autophagic protein DEF8 in Lewy bodies.
    Title: Involvement of autophagic protein DEF8 in Lewy bodies.
  2. DEF8 and Autophagy-Associated Genes Are Altered in Mild Cognitive Impairment, Probable Alzheimer's Disease Patients, and a Transgenic Model of the Disease.
    Title: DEF8 and Autophagy-Associated Genes Are Altered in Mild Cognitive Impairment, Probable Alzheimer's Disease Patients, and a Transgenic Model of the Disease.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20186, MGC104349

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lysosome localization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of bone resorption ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of ruffle assembly ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
differentially expressed in FDCP 8 homolog
Names
DEF-8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242816.2 → NP_001229745.1  differentially expressed in FDCP 8 homolog isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at an in-frame downstream start codon, compared to variant 1. The encoded protein (isoform 3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK055099, AK131370, AK225539, DC332872
    Consensus CDS
    CCDS58495.1
    UniProtKB/Swiss-Prot
    Q6ZN54
    Related
    ENSP00000456799.1, ENST00000570182.5
    Conserved Domains (2) summary
    pfam13901
    Location:224 → 424
    zf-RING_9; Putative zinc-RING and/or ribbon
    cl00040
    Location:129 → 182
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

  2. NM_001242817.2 → NP_001229746.1  differentially expressed in FDCP 8 homolog isoform 4

    See identical proteins and their annotated locations for NP_001229746.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences in the 5' UTR, compared to variant 1. These differences cause translation initiation at an in-frame downstream start codon, compared to variant 1. The encoded protein (isoform 4) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK055099, AK225539, AK296410, DC332872
    Consensus CDS
    CCDS58496.1
    UniProtKB/Swiss-Prot
    Q6ZN54
    Related
    ENSP00000456095.1, ENST00000567874.5
    Conserved Domains (2) summary
    pfam13901
    Location:174 → 374
    zf-RING_9; Putative zinc-RING and/or ribbon
    cl00040
    Location:79 → 132
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

  3. NM_001242818.2 → NP_001229747.1  differentially expressed in FDCP 8 homolog isoform 5

    See identical proteins and their annotated locations for NP_001229747.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in the 5' UTR, compared to variant 1. This difference causes translation initiation at an in-frame downstream start codon, compared to variant 1. The encoded protein (isoform 5) has a shorter N-terminus, compared to isoform 1. Variants 5 and 7 encode the same protein.
    Source sequence(s)
    AK055099, AK225539, DC332872
    Consensus CDS
    CCDS58493.1
    UniProtKB/Swiss-Prot
    Q6ZN54
    Related
    ENSP00000458019.1, ENST00000563594.6
    Conserved Domains (2) summary
    pfam13901
    Location:234 → 434
    zf-RING_9; Putative zinc-RING and/or ribbon
    cl00040
    Location:139 → 192
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

  4. NM_001242819.1 → NP_001229748.1  differentially expressed in FDCP 8 homolog isoform 6

    See identical proteins and their annotated locations for NP_001229748.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) has multiple differences in the 5' UTR and 3' coding region, compared to variant 1. These differences cause translation initiation at an in-frame downstream start codon, compared to variant 1. The encoded protein (isoform 6) has shorter N and C-termini , compared to isoform 1.
    Source sequence(s)
    AK055099, AK225539, AK295880, BC144038, DC332872
    Consensus CDS
    CCDS58494.1
    UniProtKB/Swiss-Prot
    Q6ZN54
    Conserved Domains (2) summary
    pfam13901
    Location:234 → 417
    zf-RING_9; Putative zinc-RING and/or ribbon
    cl00040
    Location:139 → 192
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

  5. NM_001242820.2 → NP_001229749.1  differentially expressed in FDCP 8 homolog isoform 5

    See identical proteins and their annotated locations for NP_001229749.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) has multiple differences in the 5' UTR, compared to variant 1. This difference causes translation initiation at an in-frame downstream start codon, compared to variant 1. The encoded protein (isoform 5) has a shorter N-terminus, compared to isoform 1. Variants 5 and 7 encode the same protein.
    Source sequence(s)
    AC092143, AK055099, AK225539, AK295880, DC332872
    Consensus CDS
    CCDS58493.1
    UniProtKB/Swiss-Prot
    Q6ZN54
    Related
    ENSP00000482524.1, ENST00000617948.4
    Conserved Domains (2) summary
    pfam13901
    Location:234 → 434
    zf-RING_9; Putative zinc-RING and/or ribbon
    cl00040
    Location:139 → 192
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

  6. NM_001242821.2 → NP_001229750.1  differentially expressed in FDCP 8 homolog isoform 2

    See identical proteins and their annotated locations for NP_001229750.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) has multiple differences in the 5' and 3' UTRs, compared to variant 1. These differences cause translation initiation at an in-frame downstream start codon, compared to variant 1. The encoded protein (isoform 2) has shorter N- and C-termini, compared to isoform 1. Variants 2, 8, and 9 encode the same protein.
    Source sequence(s)
    AK000193, BC105592, DC332872
    Consensus CDS
    CCDS45555.1
    UniProtKB/TrEMBL
    H3BMT5
    Related
    ENSP00000480073.1, ENST00000610455.4

  7. NM_001242822.2 → NP_001229751.1  differentially expressed in FDCP 8 homolog isoform 2

    See identical proteins and their annotated locations for NP_001229751.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) has multiple differences in the 5' and 3' UTRs, compared to variant 1. These differences cause translation initiation at an in-frame downstream start codon, compared to variant 1. The encoded protein (isoform 2) has shorter N- and C-termini, compared to isoform 1. Variants 2, 8, and 9 encode the same protein.
    Source sequence(s)
    BC015482, DC332872
    Consensus CDS
    CCDS45555.1
    UniProtKB/TrEMBL
    H3BMT5

  8. NM_017702.4 → NP_060172.1  differentially expressed in FDCP 8 homolog isoform 2

    See identical proteins and their annotated locations for NP_060172.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the 5' and 3' UTRs, compared to variant 1. These differences cause translation initiation at an in-frame downstream start codon, compared to variant 1. The encoded protein (isoform 2) has shorter N- and C-termini, compared to isoform 1. Variants 2, 8, and 9 encode the same protein.
    Source sequence(s)
    AK000193, DC332872
    Consensus CDS
    CCDS45555.1
    UniProtKB/TrEMBL
    H3BMT5
    Related
    ENSP00000412784.2, ENST00000418391.6

  9. NM_207514.3 → NP_997397.1  differentially expressed in FDCP 8 homolog isoform 1

    See identical proteins and their annotated locations for NP_997397.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC092143, AK055099, AK095051, AK225539, DC332872
    Consensus CDS
    CCDS10989.1
    UniProtKB/Swiss-Prot
    B3KT65, B4DK62, B4E0S9, B7Z3H6, H3BUG7, Q6ZN54, Q8N8N3, Q9NXL0
    Related
    ENSP00000268676.7, ENST00000268676.11
    Conserved Domains (2) summary
    pfam13901
    Location:295 → 495
    zf-RING_9; Putative zinc-RING and/or ribbon
    cl00040
    Location:200 → 253
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    89948755..89968060
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023365.2 → XP_016878854.1  differentially expressed in FDCP 8 homolog isoform X11

  2. XM_011523158.3 → XP_011521460.1  differentially expressed in FDCP 8 homolog isoform X3

    Conserved Domains (2) summary
    pfam13901
    Location:234 → 432
    zf-RING_9; Putative zinc-RING and/or ribbon
    cl00040
    Location:139 → 192
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

  3. XM_005256318.4 → XP_005256375.2  differentially expressed in FDCP 8 homolog isoform X4

    See identical proteins and their annotated locations for XP_005256375.2

    UniProtKB/Swiss-Prot
    Q6ZN54
    Related
    ENSP00000457627.1, ENST00000563795.1
    Conserved Domains (2) summary
    pfam13901
    Location:234 → 417
    zf-RING_9; Putative zinc-RING and/or ribbon
    cl00040
    Location:139 → 192
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

  4. XM_017023363.2 → XP_016878852.1  differentially expressed in FDCP 8 homolog isoform X9

    UniProtKB/Swiss-Prot
    B3KT65, B4DK62, B4E0S9, B7Z3H6, H3BUG7, Q6ZN54, Q8N8N3, Q9NXL0
    Conserved Domains (2) summary
    pfam13901
    Location:295 → 495
    zf-RING_9; Putative zinc-RING and/or ribbon
    cl00040
    Location:200 → 253
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

  5. XM_047434272.1 → XP_047290228.1  differentially expressed in FDCP 8 homolog isoform X11

  6. XM_017023358.3 → XP_016878847.1  differentially expressed in FDCP 8 homolog isoform X2

    UniProtKB/Swiss-Prot
    Q6ZN54
    Conserved Domains (2) summary
    pfam13901
    Location:234 → 434
    zf-RING_9; Putative zinc-RING and/or ribbon
    cl00040
    Location:139 → 192
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

  7. XM_017023359.3 → XP_016878848.1  differentially expressed in FDCP 8 homolog isoform X3

    Conserved Domains (2) summary
    pfam13901
    Location:234 → 432
    zf-RING_9; Putative zinc-RING and/or ribbon
    cl00040
    Location:139 → 192
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

  8. XM_017023360.3 → XP_016878849.1  differentially expressed in FDCP 8 homolog isoform X4

    UniProtKB/Swiss-Prot
    Q6ZN54
    Conserved Domains (2) summary
    pfam13901
    Location:234 → 417
    zf-RING_9; Putative zinc-RING and/or ribbon
    cl00040
    Location:139 → 192
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

  9. XM_017023361.3 → XP_016878850.1  differentially expressed in FDCP 8 homolog isoform X7

  10. XM_017023362.3 → XP_016878851.1  differentially expressed in FDCP 8 homolog isoform X8

  11. XM_017023364.3 → XP_016878853.1  differentially expressed in FDCP 8 homolog isoform X10

  12. XM_017023367.3 → XP_016878856.1  differentially expressed in FDCP 8 homolog isoform X2

    UniProtKB/Swiss-Prot
    Q6ZN54
    Conserved Domains (2) summary
    pfam13901
    Location:234 → 434
    zf-RING_9; Putative zinc-RING and/or ribbon
    cl00040
    Location:139 → 192
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

  13. XM_047434273.1 → XP_047290229.1  differentially expressed in FDCP 8 homolog isoform X3

  14. XM_017023369.3 → XP_016878858.1  differentially expressed in FDCP 8 homolog isoform X4

    UniProtKB/Swiss-Prot
    Q6ZN54
    Conserved Domains (2) summary
    pfam13901
    Location:234 → 417
    zf-RING_9; Putative zinc-RING and/or ribbon
    cl00040
    Location:139 → 192
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

  15. XM_011523161.4 → XP_011521463.1  differentially expressed in FDCP 8 homolog isoform X6

    See identical proteins and their annotated locations for XP_011521463.1

    Conserved Domains (2) summary
    pfam13901
    Location:295 → 399
    zf-RING_9; Putative zinc-RING and/or ribbon
    cl00040
    Location:200 → 253
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

  16. XM_011523160.4 → XP_011521462.1  differentially expressed in FDCP 8 homolog isoform X6

    See identical proteins and their annotated locations for XP_011521462.1

    Conserved Domains (2) summary
    pfam13901
    Location:295 → 399
    zf-RING_9; Putative zinc-RING and/or ribbon
    cl00040
    Location:200 → 253
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

  17. XM_011523156.4 → XP_011521458.1  differentially expressed in FDCP 8 homolog isoform X1

    See identical proteins and their annotated locations for XP_011521458.1

    Conserved Domains (2) summary
    pfam13901
    Location:234 → 338
    zf-RING_9; Putative zinc-RING and/or ribbon
    cl00040
    Location:139 → 192
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

  18. XM_011523157.4 → XP_011521459.1  differentially expressed in FDCP 8 homolog isoform X1

    See identical proteins and their annotated locations for XP_011521459.1

    Conserved Domains (2) summary
    pfam13901
    Location:234 → 338
    zf-RING_9; Putative zinc-RING and/or ribbon
    cl00040
    Location:139 → 192
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

  19. XM_011523159.4 → XP_011521461.1  differentially expressed in FDCP 8 homolog isoform X5

    Conserved Domains (2) summary
    pfam13901
    Location:268 → 372
    zf-RING_9; Putative zinc-RING and/or ribbon
    cl00040
    Location:173 → 226
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

  20. XM_011523162.4 → XP_011521464.1  differentially expressed in FDCP 8 homolog isoform X1

    See identical proteins and their annotated locations for XP_011521464.1

    Conserved Domains (2) summary
    pfam13901
    Location:234 → 338
    zf-RING_9; Putative zinc-RING and/or ribbon
    cl00040
    Location:139 → 192
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

  21. XM_017023366.3 → XP_016878855.1  differentially expressed in FDCP 8 homolog isoform X1

    Conserved Domains (2) summary
    pfam13901
    Location:234 → 338
    zf-RING_9; Putative zinc-RING and/or ribbon
    cl00040
    Location:139 → 192
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    96034997..96054302
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054380569.1 → XP_054236544.1  differentially expressed in FDCP 8 homolog isoform X11

  2. XM_054380558.1 → XP_054236533.1  differentially expressed in FDCP 8 homolog isoform X3

  3. XM_054380560.1 → XP_054236535.1  differentially expressed in FDCP 8 homolog isoform X4

  4. XM_054380567.1 → XP_054236542.1  differentially expressed in FDCP 8 homolog isoform X9

    UniProtKB/Swiss-Prot
    B3KT65, B4DK62, B4E0S9, B7Z3H6, H3BUG7, Q6ZN54, Q8N8N3, Q9NXL0

  5. XM_054380570.1 → XP_054236545.1  differentially expressed in FDCP 8 homolog isoform X11

  6. XM_054380557.1 → XP_054236532.1  differentially expressed in FDCP 8 homolog isoform X2

  7. XM_054380559.1 → XP_054236534.1  differentially expressed in FDCP 8 homolog isoform X3

  8. XM_054380561.1 → XP_054236536.1  differentially expressed in FDCP 8 homolog isoform X4

  9. XM_054380565.1 → XP_054236540.1  differentially expressed in FDCP 8 homolog isoform X7

  10. XM_054380566.1 → XP_054236541.1  differentially expressed in FDCP 8 homolog isoform X8

  11. XM_054380568.1 → XP_054236543.1  differentially expressed in FDCP 8 homolog isoform X10

  12. XM_054380573.1 → XP_054236548.1  differentially expressed in FDCP 8 homolog isoform X2

  13. XM_054380574.1 → XP_054236549.1  differentially expressed in FDCP 8 homolog isoform X3

  14. XM_054380575.1 → XP_054236550.1  differentially expressed in FDCP 8 homolog isoform X4

  15. XM_054380564.1 → XP_054236539.1  differentially expressed in FDCP 8 homolog isoform X6

  16. XM_054380563.1 → XP_054236538.1  differentially expressed in FDCP 8 homolog isoform X6

  17. XM_054380555.1 → XP_054236530.1  differentially expressed in FDCP 8 homolog isoform X1

  18. XM_054380556.1 → XP_054236531.1  differentially expressed in FDCP 8 homolog isoform X1

  19. XM_054380562.1 → XP_054236537.1  differentially expressed in FDCP 8 homolog isoform X5

  20. XM_054380571.1 → XP_054236546.1  differentially expressed in FDCP 8 homolog isoform X1

  21. XM_054380572.1 → XP_054236547.1  differentially expressed in FDCP 8 homolog isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZN54.2 GenPept UniProtKB/Swiss-Prot:Q6ZN54

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