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Tollip toll interacting protein [ Mus musculus (house mouse) ]

Gene ID: 54473, updated on 16-Apr-2024

Summary

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Official Symbol
Tollipprovided by MGI
Official Full Name
toll interacting proteinprovided by MGI
Primary source
MGI:MGI:1891808
See related
Ensembl:ENSMUSG00000025139 AllianceGenome:MGI:1891808
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930403G24Rik; 4931428G15Rik
Summary
Predicted to enable enzyme binding activity; signaling receptor binding activity; and ubiquitin-like protein binding activity. Involved in interleukin-1-mediated signaling pathway. Part of protein-containing complex. Is expressed in ovary; renal interstitium; renal vasculature; and testis. Orthologous to human TOLLIP (toll interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 75.3), cerebellum adult (RPKM 36.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 F5; 7 87.34 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (141435317..141456198, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141881580..141902461, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene mucin 5, subtypes A and C, tracheobronchial/gastric Neighboring gene STARR-seq mESC enhancer starr_20496 Neighboring gene mucin 5, subtype B, tracheobronchial Neighboring gene STARR-seq mESC enhancer starr_20497 Neighboring gene predicted gene, 32539 Neighboring gene BR serine/threonine kinase 2 Neighboring gene microRNA 3104

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tollip Orchestrates Macrophage Polarization to Alleviate Intestinal Mucosal Inflammation. Liu X, et al. J Crohns Colitis, 2022 Aug 4. PMID 35134154
  2. Protective effect of toll-interacting protein overexpression against paraquat-induced lung injury in mice and A549 cells through inhibiting oxidative stress, inflammation, and NF-κB signaling pathway. Zheng Q, et al. Respir Physiol Neurobiol, 2021 Apr. PMID 33333238
  3. Toll-Interacting Protein Regulates Immune Cell Infiltration and Promotes Colitis-Associated Cancer. Begka C, et al. iScience, 2020 Mar 27. PMID 32114379, Free PMC Article
  4. TOLLIP deficiency is associated with increased resistance to Legionella pneumophila pneumonia. Shah JA, et al. Mucosal Immunol, 2019 Nov. PMID 31462698, Free PMC Article
  5. Enhanced tumor immune surveillance through neutrophil reprogramming due to Tollip deficiency. Zhang Y, et al. JCI Insight, 2019 Jan 24. PMID 30674719, Free PMC Article

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TOLLIP inhibits lipid accumulation and the integrated stress response in alveolar macrophages to control Mycobacterium tuberculosis infection.
    Title: TOLLIP inhibits lipid accumulation and the integrated stress response in alveolar macrophages to control Mycobacterium tuberculosis infection.
  2. Tollip Inhibits IL-33 Release and Inflammation in Influenza A Virus-Infected Mouse Airways.
    Title: Tollip Inhibits IL-33 Release and Inflammation in Influenza A Virus-Infected Mouse Airways.
  3. BLK positively regulates TLR/IL-1R signaling by catalyzing TOLLIP phosphorylation.
    Title: BLK positively regulates TLR/IL-1R signaling by catalyzing TOLLIP phosphorylation.
  4. Tollip Orchestrates Macrophage Polarization to Alleviate Intestinal Mucosal Inflammation.
    Title: Tollip Orchestrates Macrophage Polarization to Alleviate Intestinal Mucosal Inflammation.
  5. TOLLIP Optimizes Dendritic Cell Maturation to Lipopolysaccharide and Mycobacterium tuberculosis.
    Title: TOLLIP Optimizes Dendritic Cell Maturation to Lipopolysaccharide and Mycobacterium tuberculosis.
  6. PHLDA1 Suppresses TLR4-Triggered Proinflammatory Cytokine Production by Interaction With Tollip.
    Title: PHLDA1 Suppresses TLR4-Triggered Proinflammatory Cytokine Production by Interaction With Tollip.
  7. Protective effect of toll-interacting protein overexpression against paraquat-induced lung injury in mice and A549 cells through inhibiting oxidative stress, inflammation, and NF-kappaB signaling pathway.
    Title: Protective effect of toll-interacting protein overexpression against paraquat-induced lung injury in mice and A549 cells through inhibiting oxidative stress, inflammation, and NF-κB signaling pathway.
  8. Toll-Interacting Protein in Pulmonary Diseases. Abiding by the Goldilocks Principle.
    Title: Toll-Interacting Protein in Pulmonary Diseases. Abiding by the Goldilocks Principle.
  9. TOLLIP decreases lung-specific TLR responses to increase susceptibility to Legionella pneumophila pneumonia.
    Title: TOLLIP deficiency is associated with increased resistance to Legionella pneumophila pneumonia.
  10. our findings reveal that resting-state STING protein level is strictly regulated by a constant tug-of-war between 'stabilizer' TOLLIP and 'degrader' IRE1alpha-lysosome that together maintain tissue immune homeostasis
    Title: Homeostatic regulation of STING protein at the resting state by stabilizer TOLLIP.
Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SUMO binding ISO
Inferred from Sequence Orthology
more info
  
enables Toll-like receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables interleukin-1, type I receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin conjugating enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within autophagy IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in interleukin-1-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in interleukin-1-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein sumoylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to endosome ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
toll-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347562.1 → NP_001334491.1  toll-interacting protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AL772165
    Consensus CDS
    CCDS85459.1
    UniProtKB/TrEMBL
    F7AT44, Q8BQL7
    Related
    ENSMUSP00000117938.3, ENSMUST00000130439.3
    Conserved Domains (2) summary
    cd04016
    Location:48 → 168
    C2_Tollip; C2 domain present in Toll-interacting protein (Tollip)
    cd14363
    Location:226 → 266
    CUE_TOLIP; CUE domain found in the C-terminal of toll-interacting protein (Tollip) and similar proteins

  2. NM_023764.4 → NP_076253.1  toll-interacting protein isoform 1

    See identical proteins and their annotated locations for NP_076253.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK016482, AL772165, CF171126
    Consensus CDS
    CCDS22020.1
    UniProtKB/Swiss-Prot
    Q543N1, Q9D5P5, Q9QZ06
    UniProtKB/TrEMBL
    Q8BQL7
    Related
    ENSMUSP00000001950.6, ENSMUST00000001950.12
    Conserved Domains (2) summary
    cd04016
    Location:52 → 172
    C2_Tollip; C2 domain present in Toll-interacting protein (Tollip)
    cd14363
    Location:230 → 270
    CUE_TOLIP; CUE domain found in the C-terminal of toll-interacting protein (Tollip) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    141435317..141456198 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QZ06.1 GenPept UniProtKB/Swiss-Prot:Q9QZ06

Gene LinkOut

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