LOC542759 pyruvate, orthophosphate dikinase 1 [Zea mays] - Gene

Summary

Gene symbol: LOC542759
Gene description: pyruvate, orthophosphate dikinase 1
Locus tag: ZEAMMB73_Zm00001d038163
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Zea mays
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade; Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea
Also known as: PODK; PPDK; pdk1; Ppdk1; C4ppdkZm1; cyppdkZm1; GRMZM2G306345
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Genomic context

Location:: chromosome: 6

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
103	current	Zm-B73-REFERENCE-NAM-5.0 (GCF_902167145.1)	6	NC_050101.1 (157076348..157086887)
102.20200423	previous assembly	B73 RefGen_v4 (GCF_000005005.2)	6	NC_024464.2 (150024464..150035047)

Chromosome 6 - NC_050101.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The data indicate that PPDK modulates endosperm metabolism, potentially through reversible adjustments to energy charge, and reveal that o2- mutations can affect the opaque phenotype through regulation of PPDK in addition to their previously demonstrated effects on storage protein gene expression.
Title: Functions of maize genes encoding pyruvate phosphate dikinase in developing endosperm.
Plants homozygous for a mutator insertion in exon 10 exhibited seedling death at the 3-leaf stage with necrosis first evident in leaf tips. C4 metabolism is essential for maize viability. The gene contributes a minor fraction of pyruvate dikinase activity in the endosperm. The opaque endosperm phenotype requires elimination of enzyme from both pyruvate dikinase genes.
Title: Functions of maize genes encoding pyruvate phosphate dikinase in developing endosperm.
Polymorphisms in the Opaque2 coding sequence and several polymorphisms in the CyPPDK1 promoter nonadditively interact to modify both lysine content and the protein-versus-starch balance in Zea mays.
Title: Epistatic interactions between Opaque2 transcriptional activator and its target gene CyPPDK1 control kernel trait variation in maize.
Increases in either PPDK RNA transcription and/or the stability of this RNA are important for the increase in PPDK protein content and activity in Miscanthus x giganteus under chilling conditions relative to maize.
Title: Cool C4 photosynthesis: pyruvate Pi dikinase expression and activity corresponds to the exceptional cold tolerance of carbon assimilation in Miscanthus x giganteus.
Pyruvate orthophosphate dikinase has a critical role in the starch-protein balance through inorganic pyrophosphate-dependent restriction of ADP-glucose synthesis in addition to its influence on the alanine-aromatic amino acid synthesis balance.
Title: Developmental analysis of maize endosperm proteome suggests a pivotal role for pyruvate orthophosphate dikinase.

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General gene information

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Markers

A06666834FMo17 (e-PCR)
- UniSTS:228772

IDP519 (e-PCR), detects polymorphism
- UniSTS:534182

pdk1 (e-PCR), detects polymorphism
- UniSTS:500212

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables kinase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables pyruvate, phosphate dikinase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in pyruvate metabolic process	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: pyruvate, phosphate dikinase 1, chloroplastic

NP_001105738.2

EC 2.7.9.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001112268.2 → NP_001105738.2 pyruvate, phosphate dikinase 1, chloroplastic precursor

Status: VALIDATED

Source sequence(s)

CABHLF010000009

UniProtKB/Swiss-Prot

C5IHE0, P11155, Q41846, Q41847, Q42367, Q7DMU6, Q9XGW9

Conserved Domains (4) summary

PRK09279
Location:72 → 944

PRK09279; pyruvate phosphate dikinase; Provisional

pfam00391
Location:498 → 577

PEP-utilizers; PEP-utilizing enzyme, mobile domain

pfam01326
Location:95 → 431

PPDK_N; Pyruvate phosphate dikinase, PEP/pyruvate binding domain

pfam02896
Location:589 → 947

PEP-utilizers_C; PEP-utilizing enzyme, TIM barrel domain