Cd160 CD160 antigen [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd160provided by MGI
Official Full Name: CD160 antigenprovided by MGI
Primary source: MGI:MGI:1860383
See related: Ensembl:ENSMUSG00000038304 AllianceGenome:MGI:1860383
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: By55
Summary: Enables MHC class I protein complex binding activity. Involved in mucosal immune response; positive regulation of interferon-gamma production; and positive regulation of natural killer cell mediated immune response to tumor cell. Acts upstream of or within defense response to Gram-negative bacterium. Located in plasma membrane. Orthologous to human CD160 (CD160 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 3 F2.1; 3 41.99 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (96706079..96736667, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (96798763..96829351, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The impact of CD160 deficiency on alloreactive CD8 T cell responses and allograft rejection.
Title: The impact of CD160 deficiency on alloreactive CD8 T cell responses and allograft rejection.
CD160 Plays a Protective Role During Chronic Infection by Enhancing Both Functionalities and Proliferative Capacity of CD8+ T Cells.
Title: CD160 Plays a Protective Role During Chronic Infection by Enhancing Both Functionalities and Proliferative Capacity of CD8+ T Cells.
Data suggest that CD160 antigen (CD160) as a co-inhibitory receptor that delivers antigen-dependent signals in natural killer T (NKT) cells to dampen cytokine production during early innate immune activation.
Title: CD160 serves as a negative regulator of NKT cells in acute hepatic injury.
The HVEM ligand CD160 counterbalances stimulatory signals in highly activated and cytotoxic CD8(+) T effector cells.
Title: HVEM and CD160: Regulators of Immunopathology During Malaria Blood-Stage.
Findings demonstrate that CD160 provides costimulatory signals to CD8(+) T cells needed for optimal CD8(+) T cell responses and protective immunity during an acute mucosal bacterial infection.
Title: CD160 Stimulates CD8(+) T Cell Responses and Is Required for Optimal Protective Immunity to Listeria monocytogenes.
CD160 may represent a suitable target for immune intervention in the setting of transplantation to modulate allogeneic cytotoxic responses.
Title: Modulation of cytotoxic responses by targeting CD160 prolongs skin graft survival across major histocompatibility class I barrier.
CD160 functionally controls cytokine production by natural killer cells.
Title: CD160 is essential for NK-mediated IFN-γ production.
Report additive effects of IL-22 and CD160 in mediating the pro-inflammatory and pro-survival aspects of the host mucosal response in Clostridium difficile infection.
Title: Interleukin-22 and CD160 play additive roles in the host mucosal response to Clostridium difficile infection in mice.
During chronic infection the number of CD4(+) T cells expressing programmed death-1 and CD160 were greater over the time-course study than the other CD4(+) T-cell inhibitory ligands.
Title: CD4(+) T-cell inhibitory ligands: a tool for characterizing dysfunctional CD4(+) T cells during chronic infection.
CD160 signaling is particularly important in CD28-independent effector/memory CD8(+) alloreactive T cell activation in vivo and therefore may serve as a novel target for prevention of allograft rejection.
Title: CD160Ig fusion protein targets a novel costimulatory pathway and prolongs allograft survival.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (5) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:234768

AU045688 (e-PCR)
- UniSTS:178893

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables MHC class I protein complex binding	IDA Inferred from Direct Assay more info	PubMed
enables MHC class I receptor activity	ISO Inferred from Sequence Orthology more info
enables MHC class Ib receptor activity	ISO Inferred from Sequence Orthology more info
enables activating MHC class I receptor activity	ISO Inferred from Sequence Orthology more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in T cell costimulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adaptive immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
involved_in mucosal immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of CD4-positive, alpha-beta T cell costimulation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of adaptive immune memory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell degranulation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell mediated immune response to tumor cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of type II interferon production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of adaptive immune response	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: CD160 antigen

Names: natural killer cell BY55; natural killer cell receptor BY55

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163496.1 → NP_001156968.1 CD160 antigen isoform a precursor

See identical proteins and their annotated locations for NP_001156968.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode isoform a.

Source sequence(s)

AK139789

Consensus CDS

CCDS17648.1

UniProtKB/Swiss-Prot

O88875, Q8C9H4

UniProtKB/TrEMBL

Q8VC80

Related

ENSMUSP00000102689.2, ENSMUST00000107074.8

Conserved Domains (2) summary

smart00410
Location:40 → 125

IG_like; Immunoglobulin like

cl11960
Location:38 → 115

Ig; Immunoglobulin domain
NM_001163497.1 → NP_001156969.1 CD160 antigen isoform b precursor

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.

Source sequence(s)

AK139789, DV660330

Consensus CDS

CCDS51011.1

UniProtKB/TrEMBL

E9Q0X3

Related

ENSMUSP00000132363.2, ENSMUST00000165991.8

Conserved Domains (2) summary

smart00410
Location:40 → 125

IG_like; Immunoglobulin like

cl11960
Location:38 → 115

Ig; Immunoglobulin domain
NM_018767.3 → NP_061237.3 CD160 antigen isoform a precursor

See identical proteins and their annotated locations for NP_061237.3

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode isoform a.

Source sequence(s)

AK042093, AK139789

Consensus CDS

CCDS17648.1

UniProtKB/Swiss-Prot

O88875, Q8C9H4

UniProtKB/TrEMBL

Q8VC80

Related

ENSMUSP00000037466.8, ENSMUST00000047702.8

Conserved Domains (2) summary

smart00410
Location:40 → 125

IG_like; Immunoglobulin like

cl11960
Location:38 → 115

Ig; Immunoglobulin domain