Ccrl2 C-C motif chemokine receptor-like 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ccrl2provided by MGI
Official Full Name: C-C motif chemokine receptor-like 2provided by MGI
Primary source: MGI:MGI:1920904
See related: Ensembl:ENSMUSG00000043953 AllianceGenome:MGI:1920904
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: E01; Ackr5; CCR11; L-CCR; Cmkbr1l2; 1810047I05Rik
Summary: Enables chemokine receptor binding activity. Involved in inflammatory response. Predicted to be integral component of plasma membrane. Predicted to be active in cytoplasm and external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and liver and biliary system. Orthologous to human CCRL2 (C-C motif chemokine receptor like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in lung adult (RPKM 16.6), placenta adult (RPKM 10.7) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F2; 9 60.92 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (110883902..110886586, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (111054834..111057518, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of CCRL2 in the Pathogenesis of Experimental Autoimmune Myocarditis via P21-Activated Kinase 1/NOD-Like Receptor Protein 3 Pathway.
Title: Role of CCRL2 in the Pathogenesis of Experimental Autoimmune Myocarditis via P21-Activated Kinase 1/NOD-Like Receptor Protein 3 Pathway.
Endothelial CCRL2 induced by disturbed flow promotes atherosclerosis via chemerin-dependent beta2 integrin activation in monocytes.
Title: Endothelial CCRL2 induced by disturbed flow promotes atherosclerosis via chemerin-dependent β2 integrin activation in monocytes.
Studies with neutralizing antibodies suggest CXCL8-mediated neutrophil activation is independent of C-C motif chemokine receptor-like 2 (CCRL2) ligand binding function.
Title: Studies with neutralizing antibodies suggest CXCL8-mediated neutrophil activation is independent of C-C motif chemokine receptor-like 2 (CCRL2) ligand binding function.
CCRL2 promotes antitumor T-cell immunity via amplifying TLR4-mediated immunostimulatory macrophage activation.
Title: CCRL2 promotes antitumor T-cell immunity via amplifying TLR4-mediated immunostimulatory macrophage activation.
The Atypical Receptor CCRL2 Is Essential for Lung Cancer Immune Surveillance.
Title: The Atypical Receptor CCRL2 Is Essential for Lung Cancer Immune Surveillance.
Ccrl2 modulates chemerin levels in the epithelial lining fluid of the lungs but does not contribute to the development of O3-induced lung pathology.
Title: Chemokine (C-C Motif) Receptor-Like 2 is not essential for lung injury, lung inflammation, or airway hyperresponsiveness induced by acute exposure to ozone.
upregulation of CCRL2 observed under inflammatory conditions is functional to finely tune CXCR2-mediated neutrophil recruitment at sites of inflammation.
Title: The atypical receptor CCRL2 is required for CXCR2-dependent neutrophil recruitment and tissue damage.
chemokine (CC motif) receptor-like 2 should be considered to be a molecule involved in the regulation of the inflammatory response associated with multiple sclerosis.
Title: CCRL2 regulates M1/M2 polarization during EAE recovery phase.
CCRL2 mRNA was not significantly changed in murine and human non-alcoholic steatohepatitis liver. CCRL2 was related to the mRNA levels of F4/80, transforming growth factor beta and alpha smooth muscle actin in murine non-alcoholic steatohepatitis.
Title: Chemokine (CC-motif) receptor-like 2 mRNA is expressed in hepatic stellate cells and is positively associated with characteristics of non-alcoholic steatohepatitis in mice and men.
Proinflammatory stimuli upregulate atypical chemerin receptor CCRL2 and VCAM-1 on endothelial cells via NF-kappaB and JAK/STAT intracellular signaling pathways.
Title: Expression, regulation, and function of atypical chemerin receptor CCRL2 on endothelial cells.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (4)

General gene information

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Markers

Ccrl2 (e-PCR), detects polymorphism
- UniSTS:495949

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables C-C chemokine binding	IBA Inferred from Biological aspect of Ancestor more info
enables C-C chemokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables C-C chemokine receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables CCR chemokine receptor binding	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables chemokine receptor activity	IEA Inferred from Electronic Annotation more info
enables chemokine receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables chemokine receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in calcium-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chemokine-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: C-C chemokine receptor-like 2

Names: G-protein coupled beta chemokine receptor; chemokine (C-C motif) receptor-like 2; chemokine (C-C) receptor 1-like 2; chemokine receptor CCR11; lipopolysaccharide inducible C-C chemokine receptor related; lipopolysaccharide-inducible C-C chemokine receptor; lipopolysacharide-inducible C-C chemokine receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001302376.1 → NP_001289305.1 C-C chemokine receptor-like 2

See identical proteins and their annotated locations for NP_001289305.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AK007808, AK145946, BC038631, BY162594

Consensus CDS

CCDS23582.1

UniProtKB/Swiss-Prot

O35457, O70171, Q3UKM6, Q4FK04, Q91YD7

Related

ENSMUSP00000143116.2, ENSMUST00000199839.5

Conserved Domains (1) summary

cd15171
Location:38 → 316

7tmA_CCRL2; CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001302377.1 → NP_001289306.1 C-C chemokine receptor-like 2

See identical proteins and their annotated locations for NP_001289306.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AC118727, AK007808, AK145946, BC038631, BY162594

Consensus CDS

CCDS23582.1

UniProtKB/Swiss-Prot

O35457, O70171, Q3UKM6, Q4FK04, Q91YD7

Conserved Domains (1) summary

cd15171
Location:38 → 316

7tmA_CCRL2; CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_017466.5 → NP_059494.2 C-C chemokine receptor-like 2

See identical proteins and their annotated locations for NP_059494.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AK007808, AK145946, BC038631

Consensus CDS

CCDS23582.1

UniProtKB/Swiss-Prot

O35457, O70171, Q3UKM6, Q4FK04, Q91YD7

Related

ENSMUSP00000107519.2, ENSMUST00000111888.3

Conserved Domains (1) summary

cd15171
Location:38 → 316

7tmA_CCRL2; CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors