Gucy1b1 guanylate cyclase 1, soluble, beta 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gucy1b1provided by MGI
Official Full Name: guanylate cyclase 1, soluble, beta 1provided by MGI
Primary source: MGI:MGI:1860604
See related: Ensembl:ENSMUSG00000028005 AllianceGenome:MGI:1860604
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GCbeta1; Gucy1b3; GC-S-beta-1
Summary: Predicted to enable several functions, including Hsp90 protein binding activity; guanylate cyclase activity; and heme binding activity. Predicted to contribute to adenylate cyclase activity and cytidylate cyclase activity. Involved in cGMP-mediated signaling and trans-synaptic signaling by nitric oxide, modulating synaptic transmission. Predicted to be located in cytoplasm. Predicted to be part of guanylate cyclase complex, soluble. Predicted to be active in presynaptic active zone. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Orthologous to human GUCY1B1 (guanylate cyclase 1 soluble subunit beta 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in frontal lobe adult (RPKM 33.9), cortex adult (RPKM 28.6) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 E3; 3 35.97 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (81939311..81982018, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (82032004..82074711, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GUCY1B3 was upregulated in neonatal rat ventricular myocytes in response to ischemia and reperfusion (IR) injury, and restored IR-induced cell death and apoptosis. Other results suggest that GUCY1B3 has an antiapoptotic effect and this effect is mediated by the activation of PKCepsilon and Akt.
Title: The β subunit of soluble guanylyl cyclase GUCY1B3 exerts cardioprotective effects against ischemic injury via the PKCε/Akt pathway.
data have provided some evidence for an alteration in the expression of alpha1 and beta1 oluble guanylyl cyclase alternative splicing forms which may contribute to the loss of sGC functions in breast cancer
Title: Differential expression of alternative transcripts of soluble guanylyl cyclase, GYCY1a3 and GUCY1b3 genes, in the malignant and benign breast tumors.
Study shows notch signaling provides a constitutive drive on expression of the major nitric oxide receptor GUCY1A3 and GUCY1B3 in arteries from mice.
Title: Hypertension reduces soluble guanylyl cyclase expression in the mouse aorta via the Notch signaling pathway.
Apo-sGC mice expressing haem-free sGC are viable and develop hypertension. The haemodynamic effects of NO are abolished, but those of the sGC activator cinaciguat are enhanced.
Title: Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice.
NO-GC has a role in growth and plasticity of hindlimb and retinal vasculature after ischemic/hypoxic insult
Title: Cell-specific impact of nitric oxide-dependent guanylyl cyclase on arteriogenesis and angiogenesis in mice.
sGC and cGMP-dependent signaling are necessary and sufficient for HNO-induced vasodilation in vivo but are not required for positive inotropic action.
Title: Soluble guanylate cyclase is required for systemic vasodilation but not positive inotropy induced by nitroxyl in the mouse.
The broad substrate-specificity of soluble guanylyl cyclase and the possible second messenger roles of cyclic nucleotides other than adenosine 3',5'-cyclic monophosphate and guanosine 3',5'-cyclic monophosphate.
Title: cCMP, cUMP, cTMP, cIMP and cXMP as possible second messengers: development of a hypothesis based on studies with soluble guanylyl cyclase α(1)β(1).
Deletion of GCbeta1 specifically in smooth muscle cells abolishes NO-induced corpus cavernosum relaxation but does not lead to infertility.
Title: Preserved fertility despite erectile dysfunction in mice lacking the nitric oxide receptor.
A VASP to Rac to soluble guanylyl cyclase negative feedback loop limited cGMP production, thereby regulating adipogenesis and energy homeostasis.
Title: A VASP-Rac-soluble guanylyl cyclase pathway controls cGMP production in adipocytes.
These data suggests a novel physiological role for PDE5 in restricting the effects of NOS3/sGC/PKG signaling pathway to modulating beta-AR stimulated I(Ca), while limiting effects on cardiac contraction.[sGC]
Title: Phosphodiesterase 5 restricts NOS3/Soluble guanylate cyclase signaling to L-type Ca2+ current in cardiac myocytes.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Gucy1b3 (e-PCR), detects polymorphism
- UniSTS:525451

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables Hsp90 protein binding	ISO Inferred from Sequence Orthology more info
contributes_to adenylate cyclase activity	ISO Inferred from Sequence Orthology more info
contributes_to cytidylate cyclase activity	ISO Inferred from Sequence Orthology more info
enables guanylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanylate cyclase activity	ISO Inferred from Sequence Orthology more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables ion binding	ISO Inferred from Sequence Orthology more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables phosphorus-oxygen lyase activity	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cGMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cGMP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cGMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cGMP-mediated signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cyclic nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in nitric oxide-cGMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in response to oxygen levels	IBA Inferred from Biological aspect of Ancestor more info
involved_in trans-synaptic signaling by nitric oxide, modulating synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
part_of guanylate cyclase complex, soluble	IBA Inferred from Biological aspect of Ancestor more info
part_of guanylate cyclase complex, soluble	ISO Inferred from Sequence Orthology more info
located_in presynaptic active zone	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic active zone cytoplasmic component	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: guanylate cyclase soluble subunit beta-1

Names: GCS-beta-1; GCS-beta-3; NO-sensitive guanylyl cyclase beta 1 subunit; beta 1 sGC; guanylate cyclase 1, soluble, beta 3; guanylate cyclase soluble subunit beta-3; soluble guanylate cyclase beta-1 subunit; soluble guanylate cyclase small subunit

NP_001155268.1

EC 4.6.1.2

NP_059497.1

EC 4.6.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001161796.1 → NP_001155268.1 guanylate cyclase soluble subunit beta-1 isoform 2

See identical proteins and their annotated locations for NP_001155268.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region compared to variant 1 that results in a frameshift. It encodes isoform 2, which has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AC121563, AC131757, BC050945

Consensus CDS

CCDS79928.1

UniProtKB/TrEMBL

Q3UTI4, Q80YP4

Related

ENSMUSP00000142119.2, ENSMUST00000193597.2

Conserved Domains (4) summary

smart00044
Location:385 → 572

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam00211
Location:412 → 572

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam07700
Location:2 → 166

HNOB; Haem-NO-binding

pfam07701
Location:207 → 406

HNOBA; Heme NO binding associated
NM_017469.4 → NP_059497.1 guanylate cyclase soluble subunit beta-1 isoform 1

See identical proteins and their annotated locations for NP_059497.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC121563, AC131757, AK139406, BC050945

Consensus CDS

CCDS38460.1

UniProtKB/Swiss-Prot

O54865

UniProtKB/TrEMBL

Q3UTI4

Related

ENSMUSP00000029635.9, ENSMUST00000029635.14

Conserved Domains (3) summary

pfam00211
Location:412 → 605

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam07700
Location:2 → 166

HNOB; Haem-NO-binding

pfam07701
Location:207 → 406

HNOBA; Heme NO binding associated