DCUN1D1 defective in cullin neddylation 1 domain containing 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: DCUN1D1provided by HGNC
Official Full Name: defective in cullin neddylation 1 domain containing 1provided by HGNC
Primary source: HGNC:HGNC:18184
See related: Ensembl:ENSG00000043093 MIM:605905; AllianceGenome:HGNC:18184
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RP42; SCRO; Tes3; DCNL1; SCCRO; DCUN1L1
Summary: Enables cullin family protein binding activity. Involved in positive regulation of protein neddylation and regulation of protein ubiquitination. Located in cytosol and nucleoplasm. Part of ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in testis (RPKM 16.2), bone marrow (RPKM 6.8) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3q26.33

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (182938074..182985918, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (185743177..185791010, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (182655862..182703706, complement)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Circ-DTL sponges miR-758-3p to accelerate cervical cancer malignant progression by regulating DCUN1D1 expression.
Title: Circ-DTL sponges miR-758-3p to accelerate cervical cancer malignant progression by regulating DCUN1D1 expression.
DCUN1D1 Is an Essential Regulator of Prostate Cancer Proliferation and Tumour Growth That Acts through Neddylation of Cullin 1, 3, 4A and 5 and Deregulation of Wnt/Catenin Pathway.
Title: DCUN1D1 Is an Essential Regulator of Prostate Cancer Proliferation and Tumour Growth That Acts through Neddylation of Cullin 1, 3, 4A and 5 and Deregulation of Wnt/Catenin Pathway.
Evidence for frequent concurrent DCUN1D1, FGFR1, BCL9 gene copy number amplification in squamous cell lung cancer.
Title: Evidence for frequent concurrent DCUN1D1, FGFR1, BCL9 gene copy number amplification in squamous cell lung cancer.
DCUN1D1 activated the FAK oncogenic signaling pathway and up-regulated PD-L1.
Title: DCUN1D1 facilitates tumor metastasis by activating FAK signaling and up-regulates PD-L1 in non-small-cell lung cancer.
REVIEW: Targeting DCN1-UBC12 Protein-Protein Interaction for Regulation of Neddylation Pathway
Title: Targeting DCN1-UBC12 Protein-Protein Interaction for Regulation of Neddylation Pathway.
Expression of DCUN1D1 in laryngeal squamous cell carcinoma and its inhibiting effect on TU-177 cells after interfered by RNA
Title: Expression of DCUN1D1 in laryngeal squamous cell carcinoma and its inhibiting effect on TU-177 cells after interfered by RNA.
ubiquitin-associated (UBA) domain-containing DCNL1 is monoubiquitylated when bound to CRLs and that this monoubiquitylation depends on the CRL-associated Ariadne RBR ligases TRIAD1 (ARIH2) and HHARI (ARIH1) and strictly requires the DCNL1's UBA domain.
Title: Coupled monoubiquitylation of the co-E3 ligase DCNL1 by Ariadne-RBR E3 ubiquitin ligases promotes cullin-RING ligase complex remodeling.
The expression of DCUN1D1 was significantly increased in colorectal cancer with a negative correlation to miR-520b expression in colorectal cancer tissues.
Title: MicroRNA-520b Functions as a Tumor Suppressor in Colorectal Cancer by Inhibiting Defective in Cullin Neddylation 1 Domain Containing 1 (DCUN1D1).
the DCN1-UBC12 interaction is inhibited by DI-591, a high-affinity, cell-permeable small-molecule inhibitor that binds to purified recombinant human DCN1 and DCN2 proteins with K i values of 10-12 nM
Title: A potent small-molecule inhibitor of the DCN1-UBC12 interaction that selectively blocks cullin 3 neddylation.
SCRO has potential to become a new target for the treatment of PC
Title: Clinical significance of SCCRO (DCUN1D1) in prostate cancer and its proliferation-inhibiting effect on Lncap cells.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH27225 (e-PCR)
- UniSTS:88916

STS-H25432 (e-PCR)
- UniSTS:2167

RH79873 (e-PCR)
- UniSTS:90321

RH16196 (e-PCR)
- UniSTS:18643

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cullin family protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables cullin family protein binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin conjugating enzyme binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-like protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in positive regulation of protein neddylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein neddylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein neddylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
part_of ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ubiquitin ligase complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: DCN1-like protein 1

Names: DCN1, defective in cullin neddylation 1, domain containing 1; DCUN1 domain-containing protein 1; RP42 homolog; defective in cullin neddylation protein 1-like protein 1; squamous cell carcinoma-related oncogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001308101.2 → NP_001295030.1 DCN1-like protein 1 isoform 2

See identical proteins and their annotated locations for NP_001295030.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate 5' exon, contains an alternate 5' terminal exon, and uses a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.

Source sequence(s)

AC092953, AF292100, AK025764, AW103206, BC013163, BI828039, BU620603, HY052047

Consensus CDS

CCDS77862.1

UniProtKB/TrEMBL

B4DM76, C9JUW4, C9JVE2

Related

ENSP00000419359.1, ENST00000469954.5

Conserved Domains (2) summary

pfam03556
Location:121 → 231

Cullin_binding; Cullin binding

cl21463
Location:1 → 36

UBA_like_SF; UBA domain-like superfamily
NM_020640.4 → NP_065691.2 DCN1-like protein 1 isoform 1

See identical proteins and their annotated locations for NP_065691.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC092953, AF292100, AK025764, AK297328, AW103206, BC013163, BU620603

Consensus CDS

CCDS3240.1

UniProtKB/Swiss-Prot

B2RB37, Q7L3G9, Q8TEX7, Q96GG9, Q9H6M1, Q9HCT3

UniProtKB/TrEMBL

B4DM76

Related

ENSP00000292782.4, ENST00000292782.9

Conserved Domains (2) summary

pfam03556
Location:136 → 246

Cullin_binding; Cullin binding

cl21463
Location:1 → 51

UBA_like_SF; UBA domain-like superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000003.12 Reference GRCh38.p14 Primary Assembly

Range

182938074..182985918 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024453601.2 → XP_024309369.2 DCN1-like protein 1 isoform X4
XM_047448339.1 → XP_047304295.1 DCN1-like protein 1 isoform X2
XM_011512914.2 → XP_011511216.1 DCN1-like protein 1 isoform X3

See identical proteins and their annotated locations for XP_011511216.1

Conserved Domains (2) summary

pfam03556
Location:121 → 219

Cullin_binding; Cullin binding

cl21463
Location:1 → 36

UBA_like_SF; UBA domain-like superfamily
XM_011512915.3 → XP_011511217.1 DCN1-like protein 1 isoform X3

See identical proteins and their annotated locations for XP_011511217.1

Conserved Domains (2) summary

pfam03556
Location:121 → 219

Cullin_binding; Cullin binding

cl21463
Location:1 → 36

UBA_like_SF; UBA domain-like superfamily
XM_011512916.3 → XP_011511218.1 DCN1-like protein 1 isoform X3

See identical proteins and their annotated locations for XP_011511218.1

Conserved Domains (2) summary

pfam03556
Location:121 → 219

Cullin_binding; Cullin binding

cl21463
Location:1 → 36

UBA_like_SF; UBA domain-like superfamily
XM_047448340.1 → XP_047304296.1 DCN1-like protein 1 isoform X3
XM_047448338.1 → XP_047304294.1 DCN1-like protein 1 isoform X1
XM_011512912.3 → XP_011511214.1 DCN1-like protein 1 isoform X1

See identical proteins and their annotated locations for XP_011511214.1

Conserved Domains (2) summary

pfam03556
Location:136 → 234

Cullin_binding; Cullin binding

cl21463
Location:1 → 51

UBA_like_SF; UBA domain-like superfamily
XM_017006634.1 → XP_016862123.1 DCN1-like protein 1 isoform X3

Conserved Domains (2) summary

pfam03556
Location:121 → 219

Cullin_binding; Cullin binding

cl21463
Location:1 → 36

UBA_like_SF; UBA domain-like superfamily