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alpi.1 alkaline phosphatase, intestinal, tandem duplicate 1 [ Danio rerio (zebrafish) ]

Gene ID: 541539, updated on 14-Apr-2024

Summary

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Official Symbol
alpi.1provided by ZNC
Official Full Name
alkaline phosphatase, intestinal, tandem duplicate 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-050327-78
See related
Ensembl:ENSDARG00000015273 AllianceGenome:ZFIN:ZDB-GENE-050327-78
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
alpi; im:7149588; wu:fa95f04; zgc:110794; si:ch211-262h13.1
Summary
Predicted to enable alkaline phosphatase activity. Predicted to be involved in dephosphorylation. Predicted to be located in plasma membrane. Predicted to be anchored component of membrane. Is expressed in several structures, including floor plate; intestine; median fin fold; periderm; and segmental plate. Human ortholog(s) of this gene implicated in inflammatory bowel disease. Orthologous to human ALPI (alkaline phosphatase, intestinal). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 22
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (38762807..38778038)
105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (38776068..38791293)

Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene si:ch211-126j24.1 Neighboring gene natriuretic peptide C Neighboring gene si:ch211-262h13.3 Neighboring gene alkaline phosphatase, intestinal, tandem duplicate 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Dynamic Evolution of the LPS-Detoxifying Enzyme Intestinal Alkaline Phosphatase in Zebrafish and Other Vertebrates. Yang Y, et al. Front Immunol, 2012. PMID 23091474, Free PMC Article
  2. Intestinal alkaline phosphatase detoxifies lipopolysaccharide and prevents inflammation in zebrafish in response to the gut microbiota. Bates JM, et al. Cell Host Microbe, 2007 Dec 13. PMID 18078689, Free PMC Article
  3. Dynamic Lkb1-TORC1 signaling as a possible mechanism for regulating the endoderm-intestine transition. Marshall KE, et al. Dev Dyn, 2010 Nov. PMID 20925120, Free PMC Article
  4. Soybean Meal and Soy Protein Concentrate in Early Diet Elicit Different Nutritional Programming Effects on Juvenile Zebrafish. Perera E, et al. Zebrafish, 2016 Feb. PMID 26716770
  5. High-Fat Diet Consumption Induces Microbiota Dysbiosis and Intestinal Inflammation in Zebrafish. Arias-Jayo N, et al. Microb Ecol, 2018 Nov. PMID 29736898

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables alkaline phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alkaline phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alkaline phosphatase, intestinal, tandem duplicate 1; intestinal-type alkaline phosphatase
Names
alkaline phosphatase, intestinal.1
iap
intestinal alkaline phosphatase 1
NP_001014375.1
XP_009294806.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014353.1 → NP_001014375.1  alkaline phosphatase, intestinal, tandem duplicate 1 precursor

    See identical proteins and their annotated locations for NP_001014375.1

    Status: PROVISIONAL

    Source sequence(s)
    BC091940
    UniProtKB/TrEMBL
    Q58EF1
    Related
    ENSDARP00000016216.10, ENSDART00000015016.10
    Conserved Domains (2) summary
    COG1785
    Location:46 → 493
    PhoA; Alkaline phosphatase [Inorganic ion transport and metabolism, General function prediction only]
    pfam00245
    Location:61 → 496
    Alk_phosphatase; Alkaline phosphatase

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007133.7 Reference GRCz11 Primary Assembly

    Range
    38762807..38778038
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009296531.2 → XP_009294806.1  intestinal-type alkaline phosphatase isoform X1

    UniProtKB/TrEMBL
    A0A8M3B5T5
    Conserved Domains (1) summary
    pfam00245
    Location:28 → 417
    Alk_phosphatase; Alkaline phosphatase
Nucleotide Protein Strain
Heading Accession and Version

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