tufm Tu translation elongation factor, mitochondrial [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tufmprovided by ZNC
Official Full Name: Tu translation elongation factor, mitochondrialprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050320-73
See related: Ensembl:ENSDARG00000104173 AllianceGenome:ZFIN:ZDB-GENE-050320-73
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: D250; fi06f04; wu:fi06f04; zgc:110766
Summary: Predicted to enable translation elongation factor activity. Predicted to be involved in mitochondrial translational elongation. Predicted to act upstream of or within translation. Predicted to be active in mitochondrion. Is expressed in several structures, including alar plate midbrain region; digestive system; optic tectum; pectoral fin bud; and segmental plate. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 4. Orthologous to human TUFM (Tu translation elongation factor, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (13582019..13599471, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (13432173..13449625, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables translation elongation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation elongation factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mitochondrial translational elongation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within translation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within translational elongation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: elongation factor Tu, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013505.2 → NP_001013523.1 elongation factor Tu, mitochondrial

See identical proteins and their annotated locations for NP_001013523.1

Status: PROVISIONAL

Source sequence(s)

BC091659

UniProtKB/TrEMBL

B2GSN2, Q5BJ17

Related

ENSDARP00000134914.1, ENSDART00000166639.2

Conserved Domains (4) summary

cd01884
Location:51 → 245

EF_Tu; Elongation Factor Tu (EF-Tu) GTP-binding proteins

PRK00049
Location:42 → 435

PRK00049; elongation factor Tu; Reviewed

cd03697
Location:253 → 339

EFTU_II; Domain II of elongation factor Tu

cd03706
Location:342 → 434

mtEFTU_III; Domain III of mitochondrial EF-TU (mtEF-TU)