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pid1 phosphotyrosine interaction domain containing 1 [ Danio rerio (zebrafish) ]

Gene ID: 541377, updated on 27-Mar-2024

Summary

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Official Symbol
pid1provided by ZNC
Official Full Name
phosphotyrosine interaction domain containing 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-050320-72
See related
Ensembl:ENSDARG00000098984 AllianceGenome:ZFIN:ZDB-GENE-050320-72
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fb36h10; zgc:113478
Summary
Predicted to be involved in negative regulation of glucose import and regulation of reactive oxygen species metabolic process. Predicted to act upstream of or within negative regulation of insulin receptor signaling pathway; regulation of cell population proliferation; and regulation of mitochondrial membrane potential. Predicted to be active in cytoplasm. Is expressed in several structures, including hypochord; notochord; optic primordium; optic vesicle; and tail bud. Orthologous to human PID1 (phosphotyrosine interaction domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 18
Exon count:
3
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (46634371..46684440, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (46636353..46686472, complement)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103909181 Neighboring gene dynein assembly factor with WDR repeat domains 1 Neighboring gene SPHK1 interactor, AKAP domain containing Neighboring gene delta/notch-like EGF repeat containing Neighboring gene uncharacterized LOC103909182

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Dner inhibits neural progenitor proliferation and induces neuronal and glial differentiation in zebrafish. Hsieh FY, et al. Dev Biol, 2013 Mar 1. PMID 23328254
  2. A morpholino-based screen to identify novel genes involved in craniofacial morphogenesis. Melvin VS, et al. Dev Dyn, 2013 Jul. PMID 23559552, Free PMC Article
  3. Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Newman M, et al. Mol Brain, 2019 May 3. PMID 31053140, Free PMC Article
  4. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in negative regulation of glucose import IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of mitochondrial membrane potential IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of reactive oxygen species metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
PTB-containing, cubilin and LRP1-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013504.1 → NP_001013522.1  PTB-containing, cubilin and LRP1-interacting protein

    See identical proteins and their annotated locations for NP_001013522.1

    Status: PROVISIONAL

    Source sequence(s)
    BC091674
    UniProtKB/TrEMBL
    A0A8M1N4P3, Q5BJ04
    Related
    ENSDARP00000138635.1, ENSDART00000167520.2
    Conserved Domains (1) summary
    cd13167
    Location:42 → 183
    PTB_P-CLI1; PTB-containing, cubilin and LRP1-interacting protein Phosphotyrosine-binding (PTB) PH-like fold

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    46634371..46684440 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021467644.1 → XP_021323319.1  PTB-containing, cubilin and LRP1-interacting protein isoform X1

    UniProtKB/TrEMBL
    A0A8M9PFE7
    Conserved Domains (1) summary
    cd13167
    Location:56 → 197
    PTB_P-CLI1; PTB-containing, cubilin and LRP1-interacting protein Phosphotyrosine-binding (PTB) PH-like fold

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395049.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    203909..255530 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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