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Gal3st1 galactose-3-O-sulfotransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 53897, updated on 5-Mar-2024

Summary

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Official Symbol
Gal3st1provided by MGI
Official Full Name
galactose-3-O-sulfotransferase 1provided by MGI
Primary source
MGI:MGI:1858277
See related
Ensembl:ENSMUSG00000049721 AllianceGenome:MGI:1858277
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cst; Gcst
Summary
Enables galactosylceramide sulfotransferase activity. Involved in galactosylceramide metabolic process. Acts upstream of or within galactosylceramide biosynthetic process; myelination; and spermatogenesis. Predicted to be integral component of membrane. Is expressed in brain; future spinal cord; heart ventricle; and spinal cord cervical region. Orthologous to human GAL3ST1 (galactose-3-O-sulfotransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in stomach adult (RPKM 105.3), duodenum adult (RPKM 57.3) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Gal3st1 in Genome Data Viewer
Location:
11 A1; 11 2.81 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (3933636..3949328)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (3983636..3999328)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_28367 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene pescadillo ribosomal biogenesis factor 1 Neighboring gene predicted gene, 46265 Neighboring gene predicted gene 11954 Neighboring gene STARR-seq mESC enhancer starr_28368 Neighboring gene SEC14-like lipid binding 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Sulfatide species with various fatty acid chains in oligodendrocytes at different developmental stages determined by imaging mass spectrometry. Hirahara Y, et al. J Neurochem, 2017 Feb. PMID 27861899
  2. Alterations in mouse brain lipidome after disruption of CST gene: a lipidomics study. Wang C, et al. Mol Neurobiol, 2014 Aug. PMID 24395133, Free PMC Article
  3. Sulfatide decrease in myelin influences formation of the paranodal axo-glial junction and conduction velocity in the sciatic nerve. Hayashi A, et al. Glia, 2013 Apr. PMID 23322453
  4. MRI characterization of paranodal junction failure and related spinal cord changes in mice. Takano M, et al. PLoS One, 2012. PMID 23300814, Free PMC Article
  5. Attenuation of kidney injuries maintains serum sulfatide levels dependent on hepatic synthetic ability: a possible involvement of oxidative stress. Sheng X, et al. Tohoku J Exp Med, 2012 May. PMID 22499158

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. lipidomics analysis demonstrated anticipated sulfatide mass deficiency in CST defect mouse brain and revealed novel brain lipidome homeostasis in these mice.
    Title: Alterations in mouse brain lipidome after disruption of CST gene: a lipidomics study.
  2. Data indicate that mice with cerebroside sulfotransferases (Cst) and UDP-glucose:ceramide glucosyltransferase (Ugcg)/Cst deficiency had lower ammonium excretion.
    Title: Sulfatides are required for renal adaptation to chronic metabolic acidosis.
  3. Protein-overload mice exhibited marked kidney injuries, enhancement of hepatic oxidative stress, decreased levels of serum and hepatic sulfatides, and decreased expression of hepatic cerebroside sulfotransferase.
    Title: Attenuation of kidney injuries maintains serum sulfatide levels dependent on hepatic synthetic ability: a possible involvement of oxidative stress.
  4. CST-deficient optic nerves were used to examine migration and proliferation of oligodendrocyte precursor cells.
    Title: Increased numbers of oligodendrocyte lineage cells in the optic nerves of cerebroside sulfotransferase knockout mice.
  5. These findings define transcriptional regulation of CST (Gal3st1) expression as a critical role for BORIS in spermatogenesis.
    Title: Expression of a testis-specific form of Gal3st1 (CST), a gene essential for spermatogenesis, is regulated by the CTCF paralogous gene BORIS.
  6. The number of OLs in the CST-null mice is also increased in the spinal cord and that this elevated OL population is maintained through, at least, 7 months of age.
    Title: Adult CST-null mice maintain an increased number of oligodendrocytes.
  7. Strong evidence is provided that murine cerebroside sulfotransferase localizes to the Golgi apparatus but not to the trans-Golgi network.
    Title: Cerebroside sulfotransferase forms homodimers in living cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables galactosylceramide sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables galactosylceramide sulfotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables galactosylceramide sulfotransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables galactosylceramide sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in galactosylceramide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within galactosylceramide biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in galactosylceramide metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glycerolipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within glycolipid biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in myelination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within myelination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sphingolipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
galactosylceramide sulfotransferase
Names
3'-phosphoadenosine-5'-phosphosulfate:Galcer sulfotransferase
3'-phosphoadenylylsulfate-galactosylceramide 3'-sulfotransferase
Galcer sulfotransferase
cerebroside sulfotransferase
NP_001171162.1
NP_001171174.1
NP_001369219.1
NP_001369220.1
NP_058618.2
XP_006514819.2
XP_006514820.1
XP_036012743.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177691.1 → NP_001171162.1  galactosylceramide sulfotransferase

    See identical proteins and their annotated locations for NP_001171162.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3, also known as form E) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK002510, AK007645, AL807395, BB804195
    Consensus CDS
    CCDS24373.1
    UniProtKB/Swiss-Prot
    Q9D8V6, Q9JHE4
    Related
    ENSMUSP00000105608.2, ENSMUST00000109981.2
    Conserved Domains (1) summary
    cl22970
    Location:4 → 408
    Sulfotransfer_2; Sulfotransferase family

  2. NM_001177703.1 → NP_001171174.1  galactosylceramide sulfotransferase

    See identical proteins and their annotated locations for NP_001171174.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK007645, AL807395, BB804195, CX239940
    Consensus CDS
    CCDS24373.1
    UniProtKB/Swiss-Prot
    Q9D8V6, Q9JHE4
    Related
    ENSMUSP00000077815.2, ENSMUST00000078757.8
    Conserved Domains (1) summary
    cl22970
    Location:4 → 408
    Sulfotransfer_2; Sulfotransferase family

  3. NM_001382290.1 → NP_001369219.1  galactosylceramide sulfotransferase

    Status: VALIDATED

    Source sequence(s)
    AL807395
    UniProtKB/Swiss-Prot
    Q9D8V6, Q9JHE4
    Conserved Domains (1) summary
    cl22970
    Location:4 → 408
    Sulfotransfer_2; Sulfotransferase family

  4. NM_001382291.1 → NP_001369220.1  galactosylceramide sulfotransferase

    Status: VALIDATED

    Source sequence(s)
    AL807395
    UniProtKB/Swiss-Prot
    Q9D8V6, Q9JHE4
    Conserved Domains (1) summary
    cl22970
    Location:4 → 408
    Sulfotransfer_2; Sulfotransferase family

  5. NM_016922.3 → NP_058618.2  galactosylceramide sulfotransferase

    See identical proteins and their annotated locations for NP_058618.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, also known as form A) represents the longest transcript. Variants 1, 2 and 3 encode the same protein. An in-frame AUG is located 29 codons upstream of the annotated translation start site but is not being annotated as a start site since it would be inhibited by an overlapping uORF with a strong Kozak sequence.
    Source sequence(s)
    AK007645, AL807395, BB804195, CX239940
    Consensus CDS
    CCDS24373.1
    UniProtKB/Swiss-Prot
    Q9D8V6, Q9JHE4
    Related
    ENSMUSP00000058348.8, ENSMUST00000063004.14
    Conserved Domains (1) summary
    cl22970
    Location:4 → 408
    Sulfotransfer_2; Sulfotransferase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    3933636..3949328
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156850.1 → XP_036012743.1  galactosylceramide sulfotransferase isoform X2

    Conserved Domains (1) summary
    cl22970
    Location:28 → 437
    Sulfotransfer_2; Sulfotransferase family

  2. XM_006514757.5 → XP_006514820.1  galactosylceramide sulfotransferase isoform X1

    See identical proteins and their annotated locations for XP_006514820.1

    UniProtKB/Swiss-Prot
    Q9D8V6, Q9JHE4
    Conserved Domains (1) summary
    cl22970
    Location:4 → 408
    Sulfotransfer_2; Sulfotransferase family

  3. XM_006514756.5 → XP_006514819.2  galactosylceramide sulfotransferase isoform X1

    See identical proteins and their annotated locations for XP_006514819.2

    UniProtKB/Swiss-Prot
    Q9D8V6, Q9JHE4
    Conserved Domains (1) summary
    cl22970
    Location:4 → 408
    Sulfotransfer_2; Sulfotransferase family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JHE4.2 GenPept UniProtKB/Swiss-Prot:Q9JHE4

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