U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ACSL1 acyl-CoA synthetase long chain family member 1 [ Bos taurus (cattle) ]

Gene ID: 537161, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
ACSL1provided by VGNC
Official Full Name
acyl-CoA synthetase long chain family member 1provided by VGNC
Primary source
VGNC:VGNC:25564
See related
Ensembl:ENSBTAG00000004344
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
FACL2
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 27
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 27 NC_037354.1 (15178952..15243838, complement)

Chromosome 27 - NC_037354.1Genomic Context describing neighboring genes Neighboring gene primase and DNA directed polymerase Neighboring gene centromere protein U Neighboring gene transfer RNA cysteine (anticodon GCA) Neighboring gene voltage-dependent anion-selective channel protein 3-like Neighboring gene helt bHLH transcription factor

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_037354.1 Chromosome 27 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Effects of overexpression of ACSL1 gene on the synthesis of unsaturated fatty acids in adipocytes of bovine. Zhao Z, et al. Arch Biochem Biophys, 2020 Nov 30. PMID 33098867
  2. High-resolution comparative mapping between human chromosomes 4 and 8 and bovine chromosome 27 provides genes and segments serving as positional candidates for udder health in cattle. Goldammer T, et al. Genomics, 2004 Oct. PMID 15475247
  3. The Molecular Characteristics of the FAM13A Gene and the Role of Transcription Factors ACSL1 and ASCL2 in Its Core Promoter Region. Liang C, et al. Genes (Basel), 2019 Nov 28. PMID 31795267, Free PMC Article
  4. ACSL1, AGPAT6, FABP3, LPIN1, and SLC27A6 are the most abundant isoforms in bovine mammary tissue and their expression is affected by stage of lactation. Bionaz M, et al. J Nutr, 2008 Jun. PMID 18492828
  5. Association of an ACSL1 gene variant with polyunsaturated fatty acids in bovine skeletal muscle. Widmann P, et al. BMC Genet, 2011 Nov 11. PMID 22078495, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Effects of overexpression of ACSL1 gene on the synthesis of unsaturated fatty acids in adipocytes of bovine.
    Title: Effects of overexpression of ACSL1 gene on the synthesis of unsaturated fatty acids in adipocytes of bovine.
  2. Results indicate that ASCL1 transcription factor binds to the core promoter region of FAM13A and positively regulates its transcription.
    Title: The Molecular Characteristics of the FAM13A Gene and the Role of Transcription Factors ACSL1 and ASCL2 in Its Core Promoter Region.
  3. The initial QTL analysis suggested the ACSL1 gene as a candidate gene for fatty acid composition in bovine skeletal muscle; subsequent analyses indicate that ACSL1 or a gene in close proximity plays a functional role in the lipid composition of beef.
    Title: Association of an ACSL1 gene variant with polyunsaturated fatty acids in bovine skeletal muscle.
  4. The results of this study suggest that suggest that SLC27A6, ACSL1, FABP3, AGPAT6, and LPIN1 coordinately regulate the channeling of fatty acids toward copious milk fat synthesis in bovine mammary.
    Title: ACSL1, AGPAT6, FABP3, LPIN1, and SLC27A6 are the most abundant isoforms in bovine mammary tissue and their expression is affected by stage of lactation.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Homology

Clone Names

  • MGC139933

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables arachidonate-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in long-chain fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in long-chain fatty-acyl-CoA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in very long-chain fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
long-chain-fatty-acid--CoA ligase 1
Names
fatty-acid-Coenzyme A ligase long chain 2
NP_001069553.1
XP_005226050.1
XP_010818563.1
XP_024842068.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001076085.1 → NP_001069553.1  long-chain-fatty-acid--CoA ligase 1

    See identical proteins and their annotated locations for NP_001069553.1

    Status: PROVISIONAL

    Source sequence(s)
    BC119914
    UniProtKB/TrEMBL
    A0A3Q1LWT4, F1MSW1, Q0VCZ8
    Related
    ENSBTAP00000061904.2, ENSBTAT00000078831.2
    Conserved Domains (1) summary
    cd05927
    Location:117 → 694
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037354.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    15178952..15243838 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024986300.2 → XP_024842068.1  long-chain-fatty-acid--CoA ligase 1 isoform X2

    UniProtKB/TrEMBL
    A0A3Q1LWT4, F1MSW1, Q0VCZ8
    Conserved Domains (1) summary
    cd05927
    Location:117 → 694
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  2. XM_005225993.5 → XP_005226050.1  long-chain-fatty-acid--CoA ligase 1 isoform X2

    See identical proteins and their annotated locations for XP_005226050.1

    UniProtKB/TrEMBL
    A0A3Q1LWT4, F1MSW1, Q0VCZ8
    Related
    ENSBTAP00000099132.1, ENSBTAT00000104086.1
    Conserved Domains (1) summary
    cd05927
    Location:117 → 694
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  3. XM_010820261.4 → XP_010818563.1  long-chain-fatty-acid--CoA ligase 1 isoform X1

    UniProtKB/TrEMBL
    A0A3Q1LVU8, A0A3Q1M3G1
    Related
    ENSBTAP00000061298.2, ENSBTAT00000083604.2
    Conserved Domains (2) summary
    PLN02736
    Location:87 → 697
    PLN02736; long-chain acyl-CoA synthetase
    cd05927
    Location:117 → 694
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.