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ADAM18 ADAM metallopeptidase domain 18 [ Bos taurus (cattle) ]

Gene ID: 536257, updated on 3-Apr-2024

Summary

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Official Symbol
ADAM18provided by VGNC
Official Full Name
ADAM metallopeptidase domain 18provided by VGNC
Primary source
VGNC:VGNC:55028
See related
BGD:BT16104; Ensembl:ENSBTAG00000004830
Gene type
protein coding
RefSeq status
MODEL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 27
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 27 NC_037354.1 (34856759..34968340)

Chromosome 27 - NC_037354.1Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase domain 2 Neighboring gene ADAM metallopeptidase domain 3A (cyritestin 1) Neighboring gene replication protein A 32 kDa subunit-like Neighboring gene S-phase kinase-associated protein 1-like Neighboring gene uncharacterized LOC101905820 Neighboring gene indoleamine 2,3-dioxygenase 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037354.1 Chromosome 27 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in binding of sperm to zona pellucida IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
disintegrin and metalloproteinase domain-containing protein 18

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037354.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    34856759..34968340
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024986398.2 → XP_024842166.1  disintegrin and metalloproteinase domain-containing protein 18 isoform X1

    UniProtKB/TrEMBL
    A0A3Q1LPW9
    Related
    ENSBTAP00000006346.6, ENSBTAT00000006346.6
    Conserved Domains (5) summary
    smart00050
    Location:399 → 476
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:478 → 615
    ACR; ADAM Cysteine-Rich Domain
    pfam01421
    Location:184 → 379
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:27 → 141
    Pep_M12B_propep; Reprolysin family propeptide
    pfam01683
    Location:601 → 648
    EB; EB module

  2. XM_059882370.1 → XP_059738353.1  disintegrin and metalloproteinase domain-containing protein 18 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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