U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

c12.1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 53435, updated on 4-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
c12.1provided by FlyBase
Primary source
FLYBASE:FBgn0040235
Locus tag
Dmel_CG12135
See related
AllianceGenome:FB:FBgn0040235
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
C12.1; CG12135; cwc15; CWC15; Dmel\CG12135
Summary
Predicted to enable RNA binding activity. Predicted to be involved in mRNA cis splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in several structures, including anterior endoderm anlage; embryonic/larval midgut; embryonic/larval midgut primordium; embryonic/larval muscle system; and germ layer. Orthologous to human CWC15 (CWC15 spliceosome associated protein homolog). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
8D7-8D7; 1-27 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9317915..9319223, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9211948..9213256, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44534 Neighboring gene long non-coding RNA:CR46533 Neighboring gene c12.2 Neighboring gene Zinc finger DHHC-type containing 8 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Alternative splicing removes an Ets interaction domain from Lozenge during Drosophila eye development. Jackson Behan K, et al. Dev Genes Evol, 2005 Aug. PMID 15868204
  2. Identification of potential pathways and biomarkers linked to progression in ALS. Huber RG, et al. Ann Clin Transl Neurol, 2023 Feb. PMID 36533811, Free PMC Article
  3. Transcriptome analysis of a long-lived natural Drosophila variant: a prominent role of stress- and reproduction-genes in lifespan extension. Doroszuk A, et al. BMC Genomics, 2012 May 4. PMID 22559237, Free PMC Article
  4. Requirement for highly efficient pre-mRNA splicing during Drosophila early embryonic development. Guilgur LG, et al. Elife, 2014 Apr 22. PMID 24755291, Free PMC Article
  5. Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes. Herold N, et al. Mol Cell Biol, 2009 Jan. PMID 18981222, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in mRNA cis splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
 PubMed 
involved_in mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome HDA PubMed 
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of precatalytic spliceosome HDA PubMed 
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
c12.1
Names
CG12135-PA
c12.1-PA

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    9317915..9319223 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_144348.3 → NP_652605.1  c12.1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652605.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V3B6
    Related
    FBpp0071259
    Conserved Domains (1) summary
    pfam04889
    Location:1 → 258
    Cwf_Cwc_15; Cwf15/Cwc15 cell cycle control protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V3B6.1 Q9V3B6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous