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Exoc7 exocyst complex component 7 [ Mus musculus (house mouse) ]

Gene ID: 53413, updated on 11-Apr-2024

Summary

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Official Symbol
Exoc7provided by MGI
Official Full Name
exocyst complex component 7provided by MGI
Primary source
MGI:MGI:1859270
See related
Ensembl:ENSMUSG00000020792 AllianceGenome:MGI:1859270
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Exo70; sec70
Summary
Involved in protein localization to ciliary membrane. Located in growth cone membrane. Is active in ciliary basal body. Is expressed in thymus primordium. Orthologous to human EXOC7 (exocyst complex component 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 16.9), CNS E14 (RPKM 16.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 E2; 11 81.11 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (116178823..116197574, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (116287997..116306750, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene signal recognition particle 68 Neighboring gene STARR-positive B cell enhancer ABC_E9847 Neighboring gene galanin receptor 2 Neighboring gene STARR-positive B cell enhancer ABC_E7099 Neighboring gene predicted gene, 26730 Neighboring gene STARR-seq mESC enhancer starr_31197 Neighboring gene STARR-seq mESC enhancer starr_31198 Neighboring gene forkhead box J1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Inducible Exoc7/Exo70 knockout reveals a critical role of the exocyst in insulin-regulated GLUT4 exocytosis. Wang S, et al. J Biol Chem, 2019 Dec 27. PMID 31740584, Free PMC Article
  2. The crystal structure of mouse Exo70 reveals unique features of the mammalian exocyst. Moore BA, et al. J Mol Biol, 2007 Aug 10. PMID 17583731, Free PMC Article
  3. The exocyst controls lysosome secretion and antigen extraction at the immune synapse of B cells. Sáez JJ, et al. J Cell Biol, 2019 Jul 1. PMID 31197029, Free PMC Article
  4. Exo70 generates membrane curvature for morphogenesis and cell migration. Zhao Y, et al. Dev Cell, 2013 Aug 12. PMID 23948253, Free PMC Article
  5. Snapin interacts with the Exo70 subunit of the exocyst and modulates GLUT4 trafficking. Bao Y, et al. J Biol Chem, 2008 Jan 4. PMID 17947242

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Insulin-stimulated GLUT4 exocytosis was markedly inhibited in Exoc7 KO adipocytes.
    Title: Inducible Exoc7/Exo70 knockout reveals a critical role of the exocyst in insulin-regulated GLUT4 exocytosis.
  2. Here we show that microtubule stabilization, triggered by engagement of the B cell receptor, acts as a cue to release centrosome-associated Exo70, which is redistributed to the immune synapse. This process is coupled to the recruitment and activation of GEF-H1, which is required for assembly of the exocyst complex, used to promote tethering and fusion of lysosomes at the immune synapse.
    Title: The exocyst controls lysosome secretion and antigen extraction at the immune synapse of B cells.
  3. Exo70 thus represents a membrane-bending protein that may couple actin dynamics and plasma membrane remodeling for morphogenesis.
    Title: Exo70 generates membrane curvature for morphogenesis and cell migration.
  4. fusion of GLUT4 vesicles is the rate-limiting step regulated by insulin downstream of Exo70-mediated tethering
    Title: Insulin regulates fusion of GLUT4 vesicles independent of Exo70-mediated tethering.
  5. Results show that Snapin interacts with the exocyst Exo70 and plays a modulatory role in GLUT4 vesicle trafficking.
    Title: Snapin interacts with the Exo70 subunit of the exocyst and modulates GLUT4 trafficking.
  6. Given the low level of sequence conservation within Exo70, this structure provides new insights into our understanding of many species-specific functions of the exocyst
    Title: The crystal structure of mouse Exo70 reveals unique features of the mammalian exocyst.
  7. The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin
    Title: The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin.
  8. Exo70 mediates AMPA receptor insertion at the postsynaptic membrane, but it does not participate in receptor targeting.
    Title: Dual role of the exocyst in AMPA receptor targeting and insertion into the postsynaptic membrane.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphatidylinositol-4,5-bisphosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in membrane fission NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitotic cytokinesis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of mitotic cytokinetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of entry of bacterium into host cell ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle docking involved in exocytosis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in vesicle tethering involved in exocytosis NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of exocyst IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of exocyst NAS
Non-traceable Author Statement
more info
 PubMed 
located_in growth cone membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule organizing center ISO
Inferred from Sequence Orthology
more info
  
is_active_in midbody ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
exocyst complex component 7
Names
exocyst complex component Exo70
exocyst component protein 70 kDa homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162872.3 → NP_001156344.1  exocyst complex component 7 isoform 2

    See identical proteins and their annotated locations for NP_001156344.1

    Status: VALIDATED

    Source sequence(s)
    AL645861
    Consensus CDS
    CCDS48983.1
    UniProtKB/TrEMBL
    Q3TIP4, Q542L0, Q7TPT3
    Related
    ENSMUSP00000102019.4, ENSMUST00000106411.10
    Conserved Domains (1) summary
    pfam03081
    Location:288 → 647
    Exo70; Exo70 exocyst complex subunit

  2. NM_001347636.3 → NP_001334565.1  exocyst complex component 7 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL645861
    Consensus CDS
    CCDS83935.1
    UniProtKB/TrEMBL
    A2AAN0, Q3TIP4, Q7TPT3
    Related
    ENSMUSP00000102021.4, ENSMUST00000106413.10

  3. NM_001362838.2 → NP_001349767.1  exocyst complex component 7 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL645861
    UniProtKB/TrEMBL
    Q69ZS4
    Conserved Domains (1) summary
    pfam03081
    Location:342 → 714
    Exo70; Exo70 exocyst complex subunit

  4. NM_001362839.2 → NP_001349768.1  exocyst complex component 7 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL645861
    UniProtKB/TrEMBL
    Q3TIP4, Q7TPT3
    Conserved Domains (1) summary
    pfam03081
    Location:288 → 660
    Exo70; Exo70 exocyst complex subunit

  5. NM_001378960.1 → NP_001365889.1  exocyst complex component 7 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL645861
    UniProtKB/TrEMBL
    Q3TIP4, Q7TPT3
    Related
    ENSMUST00000139699.8
    Conserved Domains (1) summary
    pfam03081
    Location:336 → 701
    Exo70; Exo70 exocyst complex subunit

  6. NM_001378961.1 → NP_001365890.1  exocyst complex component 7 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL645861
    UniProtKB/TrEMBL
    Q3TIP4, Q7TPT3
    Conserved Domains (1) summary
    pfam03081
    Location:305 → 670
    Exo70; Exo70 exocyst complex subunit

  7. NM_016857.4 → NP_058553.2  exocyst complex component 7 isoform 1

    See identical proteins and their annotated locations for NP_058553.2

    Status: VALIDATED

    Source sequence(s)
    AL645861
    Consensus CDS
    CCDS25664.1
    UniProtKB/Swiss-Prot
    O35250, Q8K121
    UniProtKB/TrEMBL
    Q3USE0, Q69ZS4
    Related
    ENSMUSP00000021147.8, ENSMUST00000021147.14
    Conserved Domains (1) summary
    pfam03081
    Location:313 → 691
    Exo70; Exo70 exocyst complex subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    116178823..116197574 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533734.4 → XP_006533797.1  exocyst complex component 7 isoform X1

    UniProtKB/TrEMBL
    Q69ZS4
    Conserved Domains (1) summary
    pfam03081
    Location:305 → 683
    Exo70; Exo70 exocyst complex subunit
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35250.2 GenPept UniProtKB/Swiss-Prot:O35250

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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