Pgrmc1 progesterone receptor membrane component 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pgrmc1provided by MGI
Official Full Name: progesterone receptor membrane component 1provided by MGI
Primary source: MGI:MGI:1858305
See related: Ensembl:ENSMUSG00000006373 AllianceGenome:MGI:1858305
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mPR; PPMR; Vema; HPR6.6
Summary: Enables heme binding activity. Predicted to be involved in several processes, including heme biosynthetic process; learning or memory; and positive regulation of protein localization to plasma membrane. Located in mitochondrial outer membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study non-alcoholic fatty liver disease. Orthologous to human PGRMC1 (progesterone receptor membrane component 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in liver adult (RPKM 269.7), adrenal adult (RPKM 243.6) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A3.3; X 21.0 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (35861846..35869732)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (36598193..36606079)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hepatic progesterone receptor membrane component 1 attenuates ethanol-induced liver injury by reducing acetaldehyde production and oxidative stress.
Title: Hepatic progesterone receptor membrane component 1 attenuates ethanol-induced liver injury by reducing acetaldehyde production and oxidative stress.
PGRMC1 Exerts Its Function of Anti-Influenza Virus in the Central Nervous System.
Title: PGRMC1 Exerts Its Function of Anti-Influenza Virus in the Central Nervous System.
Absence of progesterone receptor membrane component 1 reduces migration and metastasis of breast cancer.
Title: Absence of progesterone receptor membrane component 1 reduces migration and metastasis of breast cancer.
Progesterone receptor membrane component 1 (PGRMC1) binds and stabilizes cytochromes P450 through a heme-independent mechanism.
Title: Progesterone receptor membrane component 1 (PGRMC1) binds and stabilizes cytochromes P450 through a heme-independent mechanism.
PGRMC1 acts as a size-selective cargo receptor to drive ER-phagic clearance of mutant prohormones.
Title: PGRMC1 acts as a size-selective cargo receptor to drive ER-phagic clearance of mutant prohormones.
PGRMC1 in animal breast cancer tissue and blood is associated with increased tumor growth with norethisterone in contrast to progesterone and dydrogesterone: four-arm randomized placebo-controlled xenograft study.
Title: PGRMC1 in animal breast cancer tissue and blood is associated with increased tumor growth with norethisterone in contrast to progesterone and dydrogesterone: four-arm randomized placebo-controlled xenograft study.
Progesterone receptor membrane associated component 1 enhances obesity progression in mice by facilitating lipid accumulation in adipocytes.
Title: Progesterone receptor membrane associated component 1 enhances obesity progression in mice by facilitating lipid accumulation in adipocytes.
Pgrmc1 may exert neuroprotective effects by blocking Tnf-alpha induction of downstream gene targets including gbp4, ifit3, and rtp4. In addition, Pgrmc1 may alter neuroinflammation by regulating neurosteroid synthesis, both directly through steroidogenic enzyme activation and indirectly through Nr4a1 regulation of steroidogenic enzyme expression.
Title: Progesterone receptor membrane component 1 inhibits tumor necrosis factor alpha induction of gene expression in neural cells.
Loss of Pgrmc1 increased mature SREBP-1 protein level, suggesting that induction of hepatic steatosis in Pgrmc1 KO mice might be triggered by de novo lipogenesis. Moreover, Pgrmc1 KO mice were also more vulnerable to early stage of non-alcoholic steatohepatitis, showing high levels of alanine aminotransferase, obesity-linked pro-inflammatory cytokines, and fibrosis markers.
Title: Loss of progesterone receptor membrane component 1 promotes hepatic steatosis via the induced de novo lipogenesis.
survival of adult primordial ovarian follicles dependent in part on progesterone receptor membrane component 1 and 2
Title: PGRMC1/2 promotes luteal vascularization and maintains the primordial follicles of mice.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Pgrmc1 (e-PCR), detects polymorphism
- UniSTS:507136

RH124464 (e-PCR)
- UniSTS:161286

PGRMC1 (e-PCR)
- UniSTS:498205

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables heme binding	IDA Inferred from Direct Assay more info	PubMed
enables heme binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables steroid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in associative learning	ISO Inferred from Sequence Orthology more info
involved_in heme biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in memory	ISO Inferred from Sequence Orthology more info
involved_in modification of synaptic structure	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of synapse organization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lipoprotein transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell body	ISO Inferred from Sequence Orthology more info
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: membrane-associated progesterone receptor component 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.