Nptx2 neuronal pentraxin 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nptx2provided by MGI
Official Full Name: neuronal pentraxin 2provided by MGI
Primary source: MGI:MGI:1858209
See related: Ensembl:ENSMUSG00000059991 AllianceGenome:MGI:1858209
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: np2; Narp
Summary: Predicted to enable carbohydrate binding activity and metal ion binding activity. Acts upstream of or within associative learning. Predicted to be located in extracellular region. Predicted to be active in glutamatergic synapse. Is expressed in embryo; gut endoderm; and heart. Orthologous to human NPTX2 (neuronal pentraxin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in cortex adult (RPKM 14.8), frontal lobe adult (RPKM 13.5) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 84.58 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (144482697..144494288)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (144545887..144557478)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The neuronal pentraxin Nptx2 regulates complement activity and restrains microglia-mediated synapse loss in neurodegeneration.
Title: The neuronal pentraxin Nptx2 regulates complement activity and restrains microglia-mediated synapse loss in neurodegeneration.
Neuronal pentraxin 2 is required for facilitating excitatory synaptic inputs onto spinal neurons involved in pruriceptive transmission in a model of chronic itch.
Title: Neuronal pentraxin 2 is required for facilitating excitatory synaptic inputs onto spinal neurons involved in pruriceptive transmission in a model of chronic itch.
Neuropathic pain-induced cognitive dysfunction and down-regulation of neuronal pentraxin 2 in the cortex and hippocampus.
Title: Neuropathic pain-induced cognitive dysfunction and down-regulation of neuronal pentraxin 2 in the cortex and hippocampus.
Neuronal activity regulated pentraxin (narp) and GluA4 subunit of AMPA receptor may be targets for fluoxetine modulation.
Title: Neuronal activity regulated pentraxin (narp) and GluA4 subunit of AMPA receptor may be targets for fluoxetine modulation.
Central nervous system-specific, tamoxifen-induced, and hippocampus-specific deletion demonstrate that the effects of Nptx2 deletion on anxiety-like behavior are hippocampus-specific and not developmentally related. In addition, mice with Nptx2 deletion exhibit decreased hippocampal cell proliferation and increased stress-induced neuronal activity.
Title: NPTX2 is a key component in the regulation of anxiety.
findings indicate that Narp contributes to the antidepressant action of Electroconvulsive Therapy and implicate the ability of Electroconvulsive Shock to induce dendritic arborization of differentiating granule cells as a relevant step in eliciting this response.
Title: Narp Mediates Antidepressant-Like Effects of Electroconvulsive Seizures.
PTX2 was identified PTX2 as a novel partner for FX, and both proteins cooperated to prevent their SR-AI-mediated uptake by macrophages.
Title: Complex formation with pentraxin-2 regulates factor X plasma levels and macrophage interactions.
Early postnatal NPTX2(-/-)/NPTXR(-/-) mice exhibit delayed circuit maturation with a prolonged critical period permissive for giant depolarizing potentials
Title: Pentraxins coordinate excitatory synapse maturation and circuit integration of parvalbumin interneurons.
Nptx2 contributes to the development of L-DOPA-induced dyskinesia.
Title: Gene expression analyses identify Narp contribution in the development of L-DOPA-induced dyskinesia.
These findings suggest that Narp, and perhaps other neuronal pentraxins, also regulate inflammation in the nervous system.
Title: Selective expression of Narp in primary nociceptive neurons: role in microglia/macrophage activation following nerve injury.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within associative learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extrinsic component of postsynaptic specialization membrane	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in synaptic cleft	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: neuronal pentraxin-2

Names: NP-II; neuro activity regulated petaxin; neuronal pentraxin II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016789.3 → NP_058069.1 neuronal pentraxin-2 precursor

See identical proteins and their annotated locations for NP_058069.1

Status: VALIDATED

Source sequence(s)

AC164119, AK134806, DV649643

Consensus CDS

CCDS19849.1

UniProtKB/Swiss-Prot

O70340

UniProtKB/TrEMBL

Q3UYB9

Related

ENSMUSP00000071687.7, ENSMUST00000071782.8

Conserved Domains (2) summary

smart00159
Location:217 → 422

PTX; Pentraxin / C-reactive protein / pentaxin family

cl03951
Location:66 → 185

CDC37_N; Cdc37 N terminal kinase binding