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Zmiz2 zinc finger, MIZ-type containing 2 [ Mus musculus (house mouse) ]

Gene ID: 52915, updated on 21-Apr-2024

Summary

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Official Symbol
Zmiz2provided by MGI
Official Full Name
zinc finger, MIZ-type containing 2provided by MGI
Primary source
MGI:MGI:106374
See related
Ensembl:ENSMUSG00000041164 AllianceGenome:MGI:106374
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zimp7
Summary
Predicted to enable nuclear receptor coactivator activity. Predicted to be involved in epigenetic maintenance of chromatin in transcription-competent conformation and positive regulation of transcription by RNA polymerase II. Predicted to be located in mitochondrion; nuclear replication fork; and nucleoplasm. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human ZMIZ2 (zinc finger MIZ-type containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 50.9), spleen adult (RPKM 44.1) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 A1; 11 3.95 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (6339063..6356158)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (6388799..6406162)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6948 Neighboring gene STARR-positive B cell enhancer ABC_E2347 Neighboring gene predicted gene, 46270 Neighboring gene oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_28459 Neighboring gene STARR-seq mESC enhancer starr_28461 Neighboring gene STARR-seq mESC enhancer starr_28463 Neighboring gene microRNA 7651 Neighboring gene STARR-positive B cell enhancer ABC_E5206 Neighboring gene peptidylprolyl isomerase A Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:6344510-6344697 Neighboring gene H2A.Z histone variant 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Spatial and temporal expression of Zimp7 and Zimp10 PIAS-like proteins in the developing mouse embryo. Rodriguez-Magadán H, et al. Gene Expr Patterns, 2008 Feb. PMID 18053775
  2. Identification of a novel role of ZMIZ2 protein in regulating the activity of the Wnt/β-catenin signaling pathway. Lee SH, et al. J Biol Chem, 2013 Dec 13. PMID 24174533, Free PMC Article
  3. Sexually dimorphic gene expression of the Zimp7 and Zimp10 genes in embryonic gonads. Rodríguez-Magadán H, et al. Gene Expr Patterns, 2010 Jan. PMID 19931425
  4. A novel role for protein inhibitor of activated STAT (PIAS) proteins in modulating the activity of Zimp7, a novel PIAS-like protein, in androgen receptor-mediated transcription. Peng Y, et al. J Biol Chem, 2010 Apr 9. PMID 20159969, Free PMC Article
  5. Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Brady KP, et al. Genome Res, 1997 Nov. PMID 9371744, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. a novel interaction between ZMIZ2 and beta-caten
    Title: Identification of a novel role of ZMIZ2 protein in regulating the activity of the Wnt/β-catenin signaling pathway.
  2. Zimp7 is expressed in germ cells of the embryonic gonad and the adult testis.
    Title: Sexually dimorphic gene expression of the Zimp7 and Zimp10 genes in embryonic gonads.
  3. there is an interaction between Zimp7 and PIAS proteins with higher preference for PIAS3, in androgen receptor-mediated transcription
    Title: A novel role for protein inhibitor of activated STAT (PIAS) proteins in modulating the activity of Zimp7, a novel PIAS-like protein, in androgen receptor-mediated transcription.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Clone Names

  • 2410117E06Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SUMO ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear receptor coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear receptor coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in protein sumoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear replication fork ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger MIZ domain-containing protein 2
Names
PIAS-like protein Zimp7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005867.2 → NP_001005867.1  zinc finger MIZ domain-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001005867.1

    Status: VALIDATED

    Source sequence(s)
    AL607152
    Consensus CDS
    CCDS24417.1
    UniProtKB/Swiss-Prot
    Q8CIE2
    Related
    ENSMUSP00000099978.4, ENSMUST00000102914.10
    Conserved Domains (2) summary
    PHA03307
    Location:682 → 855
    PHA03307; transcriptional regulator ICP4; Provisional
    cd16791
    Location:565 → 612
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins

  2. NM_001425569.1 → NP_001412498.1  zinc finger MIZ domain-containing protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL607152
    UniProtKB/Swiss-Prot
    Q5SVX4, Q5SVX5, Q5SVX6, Q6P558, Q6P9Q5, Q8BJ00, Q8CIE2

  3. NM_001425570.1 → NP_001412499.1  zinc finger MIZ domain-containing protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL607152

  4. NM_001425571.1 → NP_001412500.1  zinc finger MIZ domain-containing protein 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL607152

  5. NM_001425572.1 → NP_001412501.1  zinc finger MIZ domain-containing protein 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL607152

  6. NM_028601.4 → NP_082877.2  zinc finger MIZ domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_082877.2

    Status: VALIDATED

    Source sequence(s)
    AL607152
    Consensus CDS
    CCDS24418.1
    UniProtKB/Swiss-Prot
    Q5SVX4, Q5SVX5, Q5SVX6, Q6P558, Q6P9Q5, Q8BJ00, Q8CIE2
    Related
    ENSMUSP00000105409.2, ENSMUST00000109786.8
    Conserved Domains (2) summary
    PHA03307
    Location:714 → 887
    PHA03307; transcriptional regulator ICP4; Provisional
    cd16791
    Location:597 → 644
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins

RNA

  1. NR_189321.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL607152

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    6339063..6356158
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246147.2 → XP_030102007.1  zinc finger MIZ domain-containing protein 2 isoform X4

    Conserved Domains (2) summary
    PHA03307
    Location:680 → 853
    PHA03307; transcriptional regulator ICP4; Provisional
    cd16791
    Location:563 → 610
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins

  2. XM_030246142.2 → XP_030102002.1  zinc finger MIZ domain-containing protein 2 isoform X2

    Related
    ENSMUSP00000105408.2, ENSMUST00000109785.2
    Conserved Domains (2) summary
    PHA03307
    Location:688 → 861
    PHA03307; transcriptional regulator ICP4; Provisional
    cd16791
    Location:571 → 618
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins

  3. XM_030246144.2 → XP_030102004.1  zinc finger MIZ domain-containing protein 2 isoform X3

    Conserved Domains (2) summary
    PHA03307
    Location:682 → 855
    PHA03307; transcriptional regulator ICP4; Provisional
    cd16791
    Location:565 → 612
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins

  4. XM_030246149.2 → XP_030102009.1  zinc finger MIZ domain-containing protein 2 isoform X6

    Conserved Domains (2) summary
    PHA03307
    Location:648 → 821
    PHA03307; transcriptional regulator ICP4; Provisional
    cd16791
    Location:531 → 578
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins

  5. XM_006514748.4 → XP_006514811.1  zinc finger MIZ domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006514811.1

    UniProtKB/Swiss-Prot
    Q5SVX4, Q5SVX5, Q5SVX6, Q6P558, Q6P9Q5, Q8BJ00, Q8CIE2
    Conserved Domains (2) summary
    PHA03307
    Location:714 → 887
    PHA03307; transcriptional regulator ICP4; Provisional
    cd16791
    Location:597 → 644
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins

  6. XM_011243734.4 → XP_011242036.1  zinc finger MIZ domain-containing protein 2 isoform X4

    Conserved Domains (2) summary
    PHA03307
    Location:680 → 853
    PHA03307; transcriptional regulator ICP4; Provisional
    cd16791
    Location:563 → 610
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins

  7. XM_011243733.4 → XP_011242035.1  zinc finger MIZ domain-containing protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q8CIE2
    Conserved Domains (2) summary
    PHA03307
    Location:688 → 861
    PHA03307; transcriptional regulator ICP4; Provisional
    cd16791
    Location:571 → 618
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins

  8. XM_017314664.3 → XP_017170153.1  zinc finger MIZ domain-containing protein 2 isoform X6

    Conserved Domains (2) summary
    PHA03307
    Location:648 → 821
    PHA03307; transcriptional regulator ICP4; Provisional
    cd16791
    Location:531 → 578
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins

  9. XM_011243735.4 → XP_011242037.1  zinc finger MIZ domain-containing protein 2 isoform X5

    Conserved Domains (2) summary
    PHA03307
    Location:656 → 829
    PHA03307; transcriptional regulator ICP4; Provisional
    cd16791
    Location:539 → 586
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CIE2.2 GenPept UniProtKB/Swiss-Prot:Q8CIE2

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