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Sgsm1 small G protein signaling modulator 1 [ Mus musculus (house mouse) ]

Gene ID: 52850, updated on 5-Mar-2024

Summary

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Official Symbol
Sgsm1provided by MGI
Official Full Name
small G protein signaling modulator 1provided by MGI
Primary source
MGI:MGI:107320
See related
Ensembl:ENSMUSG00000042216 AllianceGenome:MGI:107320
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NuIP; Rutbc2; D5Bwg1524e; E130107M15; 2410098H20Rik
Summary
Enables small GTPase binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in cytoplasmic vesicle membrane. Is expressed in several structures, including brain. Orthologous to human SGSM1 (small G protein signaling modulator 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 14.0), frontal lobe adult (RPKM 12.5) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See Sgsm1 in Genome Data Viewer
Location:
5 F; 5 55.45 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (113391086..113458654, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (113243220..113310788, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2900026A02 gene Neighboring gene VISTA enhancer mm329 Neighboring gene predicted gene, 42161 Neighboring gene LHFPL tetraspan subfamily member 7 Neighboring gene STARR-seq mESC enhancer starr_14032 Neighboring gene microRNA 7229 Neighboring gene microRNA 7230

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression pattern of NuIP gene in adult mouse brain. Luo Y, et al. Brain Res, 2009 Dec 11. PMID 19765553
  2. Nur(R1)turing a notion on the etiopathogenesis of Parkinson's disease. Federoff HJ. Neurotox Res, 2009 Oct. PMID 19526279
  3. Identification of a novel nurr1-interacting protein. Luo Y, et al. J Neurosci, 2008 Sep 10. PMID 18784308, Free PMC Article
  4. Crystal structure of the Rab9A-RUTBC2 RBD complex reveals the molecular basis for the binding specificity of Rab9A with RUTBC2. Zhang Z, et al. Structure, 2014 Oct 7. PMID 25220469
  5. Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway. Yang H, et al. Genomics, 2007 Aug. PMID 17509819

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
small G protein signaling modulator 1
Names
RUN and TBC1 domain containing 2
RUN and TBC1 domain-containing protein 2
nurr1-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162965.1 → NP_001156437.1  small G protein signaling modulator 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (b) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC130548, AC151577, AK044716, AK051018, AK053555
    UniProtKB/TrEMBL
    Q3TDT4
    Related
    ENSMUST00000145708.8
    Conserved Domains (3) summary
    smart00164
    Location:881 → 961
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cd15784
    Location:254 → 425
    PH_RUTBC; Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins
    pfam02759
    Location:44 → 188
    RUN; RUN domain

  2. NM_001254731.1 → NP_001241660.1  small G protein signaling modulator 1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 3' UTR and has multiple coding region differences, compared to variant 1, one of which results in a frameshift. The resulting protein (isoform c) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC130548, AK044716, DV644552
    Consensus CDS
    CCDS57374.1
    UniProtKB/TrEMBL
    D3YUT7, D3Z7V4
    Related
    ENSMUSP00000107944.2, ENSMUST00000112325.8
    Conserved Domains (2) summary
    smart00593
    Location:127 → 187
    RUN; domain involved in Ras-like GTPase signaling
    cd15784
    Location:254 → 425
    PH_RUTBC; Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins

  3. NM_001309526.1 → NP_001296455.1  small G protein signaling modulator 1 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in both UTRs, lacks a portion of the 5' and 3' coding regions, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (d) is shorter than isoform a.
    Source sequence(s)
    AC151577, AK051018
    Related
    ENSMUST00000147856.8
    Conserved Domains (2) summary
    smart00164
    Location:594 → 674
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cd15784
    Location:14 → 138
    PH_RUTBC; Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins

  4. NM_001309528.1 → NP_001296457.1  small G protein signaling modulator 1 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (e) has a shorter N-terminus than isoform a.
    Source sequence(s)
    AK051018, AK053555, AK167632, BP761545
    Consensus CDS
    CCDS84935.1
    UniProtKB/Swiss-Prot
    Q8BPQ7
    Related
    ENSMUSP00000084106.5, ENSMUST00000057209.12
    Conserved Domains (2) summary
    smart00164
    Location:594 → 763
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cd15784
    Location:14 → 138
    PH_RUTBC; Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins

  5. NM_172718.3 → NP_766306.2  small G protein signaling modulator 1 isoform a

    See identical proteins and their annotated locations for NP_766306.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC130548, AK044716, AK053555, AK167632, BP761545
    Consensus CDS
    CCDS39218.1
    UniProtKB/Swiss-Prot
    Q3TJ12, Q8BPQ7
    UniProtKB/TrEMBL
    B2RQR5
    Related
    ENSMUSP00000046544.7, ENSMUST00000048112.13
    Conserved Domains (3) summary
    smart00164
    Location:881 → 1050
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cd15784
    Location:254 → 425
    PH_RUTBC; Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins
    pfam02759
    Location:44 → 188
    RUN; RUN domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    113391086..113458654 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535122.4 → XP_006535185.1  small G protein signaling modulator 1 isoform X1

    UniProtKB/Swiss-Prot
    Q3TJ12, Q8BPQ7
    Conserved Domains (3) summary
    smart00164
    Location:936 → 1105
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cd15784
    Location:254 → 425
    PH_RUTBC; Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins
    pfam02759
    Location:44 → 186
    RUN; RUN domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BPQ7.2 GenPept UniProtKB/Swiss-Prot:Q8BPQ7

Gene LinkOut

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