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Macir macrophage immunometabolism regulator [ Mus musculus (house mouse) ]

Gene ID: 52392, updated on 11-Apr-2024

Summary

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Official Symbol
Macirprovided by MGI
Official Full Name
macrophage immunometabolism regulatorprovided by MGI
Primary source
MGI:MGI:1277184
See related
Ensembl:ENSMUSG00000044768 AllianceGenome:MGI:1277184
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D1Ertd622e
Summary
Acts upstream of or within negative regulation of cytokine production involved in inflammatory response and negative regulation of fibroblast migration. Predicted to be located in ciliary transition zone and cytoplasm. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human MACIR (macrophage immunometabolism regulator). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 10.5), liver E14.5 (RPKM 10.2) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 D; 1 47.76 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (97571627..97589743, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (97643902..97662018, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_01774 Neighboring gene predicted gene 7133 Neighboring gene STARR-seq mESC enhancer starr_01775 Neighboring gene STARR-seq mESC enhancer starr_01776 Neighboring gene STARR-seq mESC enhancer starr_01777 Neighboring gene predicted gene 7135 Neighboring gene STARR-seq mESC enhancer starr_01778 Neighboring gene VISTA enhancer mm1317 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:99476944-99477212 Neighboring gene STARR-positive B cell enhancer ABC_E3293 Neighboring gene STARR-seq mESC enhancer starr_01779 Neighboring gene diphosphoinositol pentakisphosphate kinase 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:99666627-99666810 Neighboring gene STARR-seq mESC enhancer starr_01781 Neighboring gene gypsy retrotransposon integrase 1 Neighboring gene peptidylglycine alpha-amidating monooxygenase Neighboring gene predicted gene, 31771

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. C5orf30 is a negative regulator of tissue damage in rheumatoid arthritis. Muthana M, et al. Proc Natl Acad Sci U S A, 2015 Sep 15. PMID 26316022, Free PMC Article
  2. Expression profiling of the developing and mature Nrl-/- mouse retina: identification of retinal disease candidates and transcriptional regulatory targets of Nrl. Yoshida S, et al. Hum Mol Genet, 2004 Jul 15. PMID 15163632
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of cytokine production involved in inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of epithelial cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of fibroblast migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cytokine production involved in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of cytokine production involved in inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of epithelial cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of fibroblast migration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of fibroblast migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in ciliary transition zone ISO
Inferred from Sequence Orthology
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
macrophage immunometabolism regulator
Names
UNC119-binding protein C5orf30 homolog
UPF0684 protein C5orf30 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355071.1 → NP_001342000.1  macrophage immunometabolism regulator

    Status: VALIDATED

    Source sequence(s)
    AC099860
    Consensus CDS
    CCDS15202.1
    UniProtKB/Swiss-Prot
    Q3UXG2, Q8VEB3
    Related
    ENSMUSP00000121997.3, ENSMUST00000149927.2
    Conserved Domains (1) summary
    pfam15435
    Location:3 → 201
    UNC119_bdg; UNC119-binding protein C5orf30 homolog

  2. NM_001355072.1 → NP_001342001.1  macrophage immunometabolism regulator

    Status: VALIDATED

    Source sequence(s)
    AC099860
    Consensus CDS
    CCDS15202.1
    UniProtKB/Swiss-Prot
    Q3UXG2, Q8VEB3
    Related
    ENSMUSP00000138031.2, ENSMUST00000153115.8
    Conserved Domains (1) summary
    pfam15435
    Location:3 → 201
    UNC119_bdg; UNC119-binding protein C5orf30 homolog

  3. NM_001355073.1 → NP_001342002.1  macrophage immunometabolism regulator

    Status: VALIDATED

    Source sequence(s)
    AC099860
    Consensus CDS
    CCDS15202.1
    UniProtKB/Swiss-Prot
    Q3UXG2, Q8VEB3
    Conserved Domains (1) summary
    pfam15435
    Location:3 → 201
    UNC119_bdg; UNC119-binding protein C5orf30 homolog

  4. NM_001355074.1 → NP_001342003.1  macrophage immunometabolism regulator

    Status: VALIDATED

    Source sequence(s)
    AC099860
    Consensus CDS
    CCDS15202.1
    UniProtKB/Swiss-Prot
    Q3UXG2, Q8VEB3
    Conserved Domains (1) summary
    pfam15435
    Location:3 → 201
    UNC119_bdg; UNC119-binding protein C5orf30 homolog

  5. NM_133825.3 → NP_598586.1  macrophage immunometabolism regulator

    See identical proteins and their annotated locations for NP_598586.1

    Status: VALIDATED

    Source sequence(s)
    AK152370, AK162223, BB611324, BY419889
    Consensus CDS
    CCDS15202.1
    UniProtKB/Swiss-Prot
    Q3UXG2, Q8VEB3
    Related
    ENSMUSP00000051034.8, ENSMUST00000053033.14
    Conserved Domains (1) summary
    pfam15435
    Location:3 → 201
    UNC119_bdg; UNC119-binding protein C5orf30 homolog

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    97571627..97589743 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529751.2 → XP_006529814.1  macrophage immunometabolism regulator isoform X1

    See identical proteins and their annotated locations for XP_006529814.1

    UniProtKB/Swiss-Prot
    Q3UXG2, Q8VEB3
    Conserved Domains (1) summary
    pfam15435
    Location:3 → 201
    UNC119_bdg; UNC119-binding protein C5orf30 homolog
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VEB3.1 GenPept UniProtKB/Swiss-Prot:Q8VEB3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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