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Ccnc cyclin C [ Mus musculus (house mouse) ]

Gene ID: 51813, updated on 11-Apr-2024

Summary

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Official Symbol
Ccncprovided by MGI
Official Full Name
cyclin Cprovided by MGI
Primary source
MGI:MGI:1858199
See related
Ensembl:ENSMUSG00000028252 AllianceGenome:MGI:1858199
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CG1C
Summary
Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity and identical protein binding activity. Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in negative regulation of triglyceride metabolic process; positive regulation of transcription by RNA polymerase II; and protein ubiquitination. Part of mediator complex. Is expressed in central nervous system; limb; and retina. Orthologous to human CCNC (cyclin C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 5.3), CNS E14 (RPKM 4.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 A3; 4 8.86 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (21727705..21759917)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (21727701..21759922)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57726 Neighboring gene STARR-seq mESC enhancer starr_09725 Neighboring gene PR domain containing 13 Neighboring gene STARR-seq mESC enhancer starr_09729 Neighboring gene STARR-seq mESC enhancer starr_09730 Neighboring gene STARR-positive B cell enhancer ABC_E3481 Neighboring gene STARR-seq mESC enhancer starr_09732 Neighboring gene STARR-seq mESC enhancer starr_09733 Neighboring gene thiosulfate sulfurtransferase (rhodanese)-like domain containing 3 Neighboring gene ubiquitin specific petidase 45 Neighboring gene RIKEN cDNA 4930528A17 gene Neighboring gene STARR-seq mESC enhancer starr_09734 Neighboring gene PNN interacting serine/arginine-rich

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The extent of cyclin C promoter occupancy directs changes in stress-dependent transcription. Stieg DC, et al. J Biol Chem, 2020 Nov 27. PMID 32934007, Free PMC Article
  2. Mitochondrial translocation of cyclin C stimulates intrinsic apoptosis through Bax recruitment. Jezek J, et al. EMBO Rep, 2019 Sep. PMID 31385392, Free PMC Article
  3. Cyclin C mediates stress-induced mitochondrial fission and apoptosis. Wang K, et al. Mol Biol Cell, 2015 Mar 15. PMID 25609094, Free PMC Article
  4. 3.6-KB mouse cyclin C promoter fragment is predominantly active in the testis. Blazsó P, et al. Acta Biol Hung, 2012 Mar. PMID 22453798
  5. Synergistic repression of thyroid hyperplasia by cyclin C and Pten. Jezek J, et al. J Cell Sci, 2019 Aug 15. PMID 31331961, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Stress-Induced Cyclin C Translocation Regulates Cardiac Mitochondrial Dynamics.
    Title: Stress-Induced Cyclin C Translocation Regulates Cardiac Mitochondrial Dynamics.
  2. The extent of cyclin C promoter occupancy directs changes in stress-dependent transcription.
    Title: The extent of cyclin C promoter occupancy directs changes in stress-dependent transcription.
  3. his study uncovers new synergistic activities of Pten and cyclin C to promote quiescence through maintenance of p21 and p53.
    Title: Synergistic repression of thyroid hyperplasia by cyclin C and Pten.
  4. cyclin C binding stimulates the reduction of low-GTPase activity Drp1 oligomers into dimers capable of producing high-GTPase activity filaments.
    Title: Cyclin C directly stimulates Drp1 GTP affinity to mediate stress-induced mitochondrial hyperfission.
  5. these data indicate that CycC activates adipogenesis in part by stimulating the transcriptional activity of C/EBPalpha.
    Title: Cyclin C regulates adipogenesis by stimulating transcriptional activity of CCAAT/enhancer-binding protein α.
  6. our results suggest that mTORC1 activation in NAFLD and insulin resistance results in down-regulation of the CDK8-CycC complex and elevation of lipogenic protein expression.
    Title: mTORC1 Down-Regulates Cyclin-Dependent Kinase 8 (CDK8) and Cyclin C (CycC).
  7. cyclin C connects stress-induced mitochondrial hyperfission and programmed cell death in mammalian cells.
    Title: Cyclin C mediates stress-induced mitochondrial fission and apoptosis.
  8. cyclin-C-CDK complexes phosphorylate the Notch1 intracellular domain (ICN1) and promote ICN1 degradation
    Title: Cyclin C is a haploinsufficient tumour suppressor.
  9. Data show that the isolated 3.6-KB promoter fragment alone is not sufficient for the complete physiological modulation of cyclin C RNA.
    Title: 3.6-KB mouse cyclin C promoter fragment is predominantly active in the testis.
  10. Results identify LSF as only the second known target (in addition to pRb) of cyclin C/CDK2 activity during progression from quiescence to early G(1).
    Title: Phosphorylation by cyclin C/cyclin-dependent kinase 2 following mitogenic stimulation of murine fibroblasts inhibits transcriptional activity of LSF during G1 progression.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G0 to G1 transition ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of triglyceride metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of CKM complex ISO
Inferred from Sequence Orthology
more info
  
part_of cyclin-dependent protein kinase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
  
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cyclin-C
Names
dJ199J3.4 (cyclin C)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122982.3 → NP_001116454.1  cyclin-C isoform 2

    See identical proteins and their annotated locations for NP_001116454.1

    Status: VALIDATED

    Source sequence(s)
    AL772187
    Consensus CDS
    CCDS51127.1
    UniProtKB/TrEMBL
    Q05BN1, Q8CAS3
    Related
    ENSMUSP00000103875.3, ENSMUST00000108240.3
    Conserved Domains (2) summary
    cd20513
    Location:40 → 146
    CYCLIN_CCNC_rpt1; first cyclin box found in cyclin-C (CCNC) and similar proteins
    cd20514
    Location:154 → 245
    CYCLIN_CCNC_rpt2; second cyclin box found in cyclin-C (CCNC) and similar proteins

  2. NM_001290420.2 → NP_001277349.1  cyclin-C isoform 3

    See identical proteins and their annotated locations for NP_001277349.1

    Status: VALIDATED

    Source sequence(s)
    AL772187
    Consensus CDS
    CCDS71350.1
    UniProtKB/TrEMBL
    Q05BN1, Q3UXL9
    Related
    ENSMUSP00000113682.2, ENSMUST00000120679.8
    Conserved Domains (1) summary
    cl28538
    Location:1 → 212
    CCL1; Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]

  3. NM_001290422.2 → NP_001277351.1  cyclin-C isoform 2

    See identical proteins and their annotated locations for NP_001277351.1

    Status: VALIDATED

    Source sequence(s)
    AL772187
    Consensus CDS
    CCDS51127.1
    UniProtKB/TrEMBL
    Q05BN1, Q8CAS3
    Related
    ENSMUSP00000069076.5, ENSMUST00000065928.11
    Conserved Domains (2) summary
    cd20513
    Location:40 → 146
    CYCLIN_CCNC_rpt1; first cyclin box found in cyclin-C (CCNC) and similar proteins
    cd20514
    Location:154 → 245
    CYCLIN_CCNC_rpt2; second cyclin box found in cyclin-C (CCNC) and similar proteins

  4. NM_001424981.1 → NP_001411910.1  cyclin-C isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL772187

  5. NM_001424982.1 → NP_001411911.1  cyclin-C isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL772187

  6. NM_001424983.1 → NP_001411912.1  cyclin-C isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL772187

  7. NM_016746.5 → NP_058026.2  cyclin-C isoform 1

    See identical proteins and their annotated locations for NP_058026.2

    Status: VALIDATED

    Source sequence(s)
    AL772187
    Consensus CDS
    CCDS17998.1
    UniProtKB/Swiss-Prot
    Q0P542, Q5XKQ9, Q62447, Q9WUZ4
    UniProtKB/TrEMBL
    Q497T2
    Related
    ENSMUSP00000100062.2, ENSMUST00000102997.8
    Conserved Domains (2) summary
    cd20513
    Location:40 → 146
    CYCLIN_CCNC_rpt1; first cyclin box found in cyclin-C (CCNC) and similar proteins
    cd20514
    Location:154 → 245
    CYCLIN_CCNC_rpt2; second cyclin box found in cyclin-C (CCNC) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    21727705..21759917
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164233.1 → XP_036020126.1  cyclin-C isoform X1

    UniProtKB/TrEMBL
    Q497T2
    Conserved Domains (2) summary
    cd20513
    Location:33 → 139
    CYCLIN_CCNC_rpt1; first cyclin box found in cyclin-C (CCNC) and similar proteins
    cd20514
    Location:147 → 238
    CYCLIN_CCNC_rpt2; second cyclin box found in cyclin-C (CCNC) and similar proteins

  2. XM_036164234.1 → XP_036020127.1  cyclin-C isoform X2

    UniProtKB/TrEMBL
    Q05BN1
    Conserved Domains (2) summary
    cd20513
    Location:33 → 139
    CYCLIN_CCNC_rpt1; first cyclin box found in cyclin-C (CCNC) and similar proteins
    cd20514
    Location:147 → 238
    CYCLIN_CCNC_rpt2; second cyclin box found in cyclin-C (CCNC) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62447.4 GenPept UniProtKB/Swiss-Prot:Q62447

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